identifying the function of the mammalian Siah1 and Siah2 in the cell

Anti Siah1 Polyclonal antibody,Rabbit


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Anti Siah1 Polyclonal antibody,Rabbit
Anti Siah2 Polyclonal Antibody,Rabbit

 

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Anti Siah1 Polyclonal antibody,Rabbit

Anti Siah2 Polyclonal Antibody,Rabbit

 

 

For Research Use Only

Background

The turnover of a protein is precisely under control in the cell. Particularly, the system of controlling protein degradation via the ubiquitin-proteosome pathway is involving in many kinds of process in the cell. The Drosophila Seven in absentina (Sina) gene product originally was identified as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah1 and Siah2, have been described that they might involve in ubiquitin-mediated proteolysis of several proteins, as well as in growth arrest and p53-induced apoptosis. This antibody is very useful for identifying the function of the mammalian Siah1 in the cell.

Package Size 25µg (100µL/vial)
Format Rabbit polyclonal antibody 0.25mg/mL
Buffer PBS [containing 50% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Storage
Purification method
Below –20°C
This antibody was purified from rabbit serum by affinity chromatography.
Working dilution Western Blotting: 0.2µg/mL
Western Blotting

Sample:293 cell lysate
1) control
2) Siah1gene transgenic cell+MG-132 (protease inhibitor)

Preparation of antibodies and instruction
Dr.Koki Moriyoshi at Department of Biological Sciences, Kyoto University Faculty of Medicine

<Reference>
1. Development; 117, p1333-1343 (1993)
2. Genes Development; 11, p2701-2714 (1997)
3. Molecular Cell Biol.; 7, p915-926 (2001)
4. Molecular Cell Biol.; 7, p927-936 (2001)
5. Nature Struct. Biol.; 9, p68-75 (2002)

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To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



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