Anti Siah2 Polyclonal Antibody,Rabbit


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Anti Siah1 Polyclonal antibody,Rabbit
Anti Siah2 Polyclonal Antibody,Rabbit

 

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Anti Siah1 Polyclonal antibody,Rabbit

Anti Siah2 Polyclonal Antibody,Rabbit

 

For Research Use Only

Background

The turnover of a protein is precisely under control in the cell. Particularly, the system of controlling protein degradation via the ubiquitin-proteosome pathway is involving in many kinds of process in the cell. The Drosophila Seven in absentina (Sina) gene product originally was identified as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah1 and Siah2, have been described that they might involve in ubiquitin-mediated proteolysis of several proteins, as well as in growth arrest and p53-induced apoptosis. Siah2 is expressed in olfactory epithelium, retina, forebrain and proliferating cartilage of developing bone by mRNA level.
This antibody is very useful for identifying the function of the mammalian Siah2 in the cell.

Package Size 25µg (100µL/vial)
Format Rabbit polyclonal antibody 0.25mg/mL
Buffer Block Ace as a stabilizer, containing 0.1%Proclin as bacteriostat
Storage Below –20°C
Once thawed, store at 4?. Repeated freeze-thaw cycles should be avoided.
This antibody was purified from rabbit serum by affinity chromatography.
Working dilution Western Blotting: 0.8µg/mL

Western Blotting

Sample:293 cell lysate
1) control
2) Siah2 gene transgenic cell+MG-132 (protease inhibitor)

Preparation of antibodies and instruction
Dr.Koki Moriyoshi at Department of Biological Sciences, Kyoto University Faculty of Medicine

<Reference>
1. Della NG, Senior PV, Bowtel DD : Development : Isolation and characterization of murine homologues of the Drosophila seven in absentia gene (sina) : 117(4) : 1333-1343 (1993)
2. Hu G, Zhang S, Vidal M, Baer JL, Xu T, Fearon ER : Genes Development : Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. : 11(20) : 2701-2714 (1997)
3. Molecular Cell Biol.; 7, p915-926 (2001)
4. Molecular Cell Biol.; 7, p927-936 (2001)
5. Polekhina G, House CM, Traficante N, Mackay JP, Relaix F, Sassoon DA, Parker MW, Bowtell DD : Nature Struct. Biol.: Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling : 9(1) : 68-75 (2002)

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To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



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