useful for research for diabetes, complications of diabetes

Anti AGE-1 Monoclonal Antibody


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Background

The products of the nonenzymatic glycation and oxidation of proteins, lipids and nucleic acids, the advanced glycation end-products (AGEs), accumulate in various pathological conditions, such as diabetes, inflammation, renal failure, and aging. AGEs accumulate at site of microvascular injury in diabetes, including the kidney, the retina, and within the vasculature. The enhanced formation of AGEs also exists in various disease, such as atherosclerosis, Alzheimer’s disease, end-stage renal disease (ESRD), rheumatoid arthritis and liver cirrhosis.
AGEs can arise not only from glucose, but also from dicarbonyl compounds, short chain-reducing sugars and other metabolic pathways of glucose. It has been showed that glucose-derived AGEs (named AGE-1) causes apoptotic cell death and induces hyperfiltration and microalbuminuria by stimulating secretion of VEGF and MCP-1 proteins in the human mesangial cells. Therefore, AGE-1 may be involved in the pathogenesis of the early stage of diabetic nephropathy.
This antibody is specific to AGE-1 and will be useful to research for diabetes, complications of diabetes.


 AGEs Antibody Flyer [PDF]
 AGEs Antibody Flyer@(print file) [PDF]

Application

WB 0.1 μg/mL
IHC Not tested
ICC Not tested
ELISA 0.1 μg/mL
FCM Not tested
Neutralization Not tested
IP Not tested

<Reference>
1. Takeuchi M. et al.: Detection of noncarboxymethyllysine and carboxymethyllysine advanced glycation end products(AGE) in serum of diabetic patients. Mol Med. 1999 Jun;5(6):393-405.
2. Takeuchi M. et al.: Immunological evidence that non-carboxymethyllysine advanced glycation end-products are produced from short chain sugars and dicarbonyl compounds in vivo. Mol Med. 2000 Feb;6(2):114-25.
3. Takeuchi M. et al.: Immunological detection of a novel advanced glycation end-product. Mol Med. 2001 Nov;7(11):783-91.
4. Yamagishi S. et al.: Advanced glycation end product-induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in human-cultured mesangial cells. J Biol Chem. 2002 Jun 7;277(23):20309-15. Epub 2002 Mar

This product is generated from GANP® mice

Product List

Product Name Cat# Quantity Price

Anti AGE1, - (Mouse) Unlabeled DataSheet

KAL-KG132

10 UG ¥55,000
$734