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  • Anti Human TSHR[thyroid stimulating hormone receptor] Monoclonal Antibody (Clone No. 3A6)

useful for research on autoimmune thyroid disease, osteoporosis, tumor such as melanoma.

Anti Human TSHR[thyroid stimulating hormone receptor] Monoclonal Antibody (Clone No. 3A6)


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Background

The thyroid stimulating hormone receptor (TSHR) ,also known as LGR3,@is a member of the leucine-rich repeat-containing G protein-coupled receptor (LGR) family. TSHR is expressed mainly in thyroid follicular cells and is activated by TSH, which regulates the growth and function of thyroid follicular cells.
Graves’ disease is a common type of autoimmune thyroid disease, in that the generation of autoantibodies against the TSHR causes continuous stimulation of the thyroid gland hyperthyroidism. It has been demonstrated that TSHR are present on the surface of melanoma cells, through which TSH promotes melanoma growth. It has been also showed that TSH/TSHR regulates transcription of the TNFα gene, osteoclast formation and osteoporosis arise from TSHR deficiency. This antibody is specific to TSHR and will be useful for research on autoimmune thyroid disease, osteoporosis, tumor such as melanoma.

Application

WB Not tested
IHC Not tested
ICC Not tested
ELISA Not tested
FCM 1.0-5.0 μg/mL
Neutralization Not tested
IP Not tested

Character

Primary Source HGNC:12373
Type Monoclonal
Immunogen plasmid vector
Raised in Mouse
Myeloma P3U1
Clone number 3A6
Isotype IgG2aκ
Source Serum Free Medium
Purification notes ProteinG
Cross Reactivity Not yet tested in other species.
Concentration 0.25 mg/mL
ContentsiVolumej 50 μgi200 μL/vialj
Label Unlabeled
Buffer PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]
Storage Store below –20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided.

<Reference>
1. Kaneda T. et al.: An improved Graves' disease model established by using in vivo electroporation exhibited long-term immunity to hyperthyroidism in BALB/c mice. Endocrinology. 2007 May;148(5):2335-44. Epub 2007 Jan 25.
2. Ellerhorst JA. et al.: Human melanoma cells express functional receptors for thyroid-stimulating hormone. Endocr Relat Cancer. 2006 Dec;13(4):1269-77.
3. Hase H. et al.: TNFalpha mediates the skeletal effects of thyroid-stimulating hormone. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12849-54. Epub 2006 Aug 14.
4. Szkudlinski MW. et al.: Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships. Physiol Rev. 2002 Apr;82(2):473-502. Review.

Product List

Product Name Cat# Quantity Price

Anti Thyroid Stimulating Hormone Receptor / TSHR, Human (Mouse) Unlabeled DataSheet

KAL-KG136

50 UG ¥55,000
$734

“Anti Human TSHR[thyroid stimulating hormone receptor] Monoclonal Antibody (Clone No. 3A6)” also belongs to the following categories.