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  • Anti Human DOR Monoclonal Antibody (Clone No. 1E7)

useful for the research in brain and active T cells.

Anti Human DOR Monoclonal Antibody (Clone No. 1E7)


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Background

OPRD1 (opioid receptor, delta 1), also known as DOR, belongs to the rhodopsin subfamily of G-protein-coupled receptor (GPCR) family. OPRD1 is consist of 372 amino acids and is located largely in the brain, active T cells. OPRD1 may be responsible for analgesia, dysphoria, immunopotentiation Activation of native T cells markedly up-regulates the expression of OPRD1 and OPRD1 modulates T cell proliferation, IL-2 production, chemotaxis, and intracellular signaling. Stimulating OPRD1 expressed by activated CD4+ T cells significantly suppresses the expression of HIV-1. In addition, it has been showed that activation of OPRD1 is neuroprotective against severe stress, such as hypoxia-, glutamate-induced cell injury.

Application

WB 1.0 μg/mL
IHC Not tested
ICC 1.0 μg/mL
ELISA Not tested
FCM 1.0 μg/mL
Neutralization Not tested
IP 1.0 μg/mL


Blue:DAPI
Green:KG142i2nd Ab :anti-mIgG FITC-conjugatedj
Immunocytochemical staining of HEK293T cells overexpressing human DOR

Character

Primary Source HGNC:8153
Type Monoclonal
Immunogen hDOR expressing cell line
Raised in Mouse
Myeloma P3U1
Clone number ,1E7
Isotype IgG1 κ
Source Serum Free Medium
Purification notes ProteinG
Cross Reactivity Not yet tested in other species.
Concentration 0.25 mg/mL
Contents(Volume) 25 μg(100 μL/vial)
Label Unlabeled
Buffer PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]
Storage Store below -20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided.

<Reference>
1. Kieffer BL. et al.: The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12048-52.
2. Sharp BM. et al.: Immunofluorescence detection of delta opioid receptors (DOR) on human peripheral blood CD4+ T cells and DOR-dependent suppression of HIV-1 expression. J Immunol. 2001 Jul 15;167(2):1097-102.
3. Ma MC. et al.: Oxygen-sensitive {delta}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection. J Biol Chem. 2005 Apr 22;280(16):16208-18. Epub 2005 Feb 1.

Product List

Product Name Cat# Quantity Price

Anti DOR, Human (Mouse) Unlabeled DataSheet

KAL-KG142

25 UG ¥55,000
$734

“Anti Human DOR Monoclonal Antibody (Clone No. 1E7)” also belongs to the following categories.