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For MALT lymphoma research and dissection of the of the MALT1-IKK signaling system in epithelial cells

Anti human MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1) Polyclonal Antibody


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Background

MALT lymphomas originate in mucosa associated lymphoid tissue and may form in various internal organs including the gastrointestinal tract and bronchus. Investigation of a chromosomal translocation characteristic of MALT lymphomas identified the MALT1 gene (MALT Associated Lymphoma Translocation Gene 1; paracaspase). MALT1 translocations result in the fusion of MALT1 with the AIP2 (inhibitor of apoptosis), suggesting that increased inhibition of apoptosis by a MALT1/AIP2 fusion protein may contribute to lymphoma survival.

Moreover, MALT1 is required for NF-kB activation induced by T-cell receptor, regulates activation of cannonical IκB kinase (IKK) in lymphoid cells, and is a downstream component of BCL10 signaling. MALT1 also appears to play an important role in epithelial cell differentiation although this role in this process is far from clear.

This antibody is therefore useful for investigating MALT lymphoma and the relationships between MALT1 and IKK.

Application

Western blotting : 0.5`2 μg/mL

Western Blotting

Sample F
?Human MALT1(IPTG+) expressed in E Coli.
?(IPTG-)

Preparation of antibodies and instructionF
Imai K, Chiba T
Nippon Dental University

Character

Package Size 25μg (100μL / vial)
Format Rabbit polyclonal antibody 0.25mg/mL
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Storage Store below -20°C
Once thawed, store at 4°C. Repeated freeze-thaw cycles should be avoided.
Purification method This antibody was purified from rabbit serum immunized with partial peptide of human Mucosa Associated Lymphoid Tissue 1 by peptide affinity chromatography.
Working dilution For western blotting ; 0.5`2 μg/mL

<Reference>
1. Kaufman CK. et al. : J Cell Biol. 2000 May;149(5):999-1004 PMID: 10831603 2. Willis TG. et al. : Cell 1999 Jan 8;96(1):35-45 PMID: 9989495
3. Lucas PC. et al. : J Biol Chem. 2001 Jun 1;276(22):19012-9 PMID: 11262391
4. Li Q. et al. : Genes Dev. 1999 May 15;13(10):1322-8 PMID: 10346820
5. Seitz CS. et al. : Proc Natl Acad Sci USA. 1998 Mar 3;95(5):2307-12 PMID: 9482881
6. Zandi E. et al. : Cell 1997 Oct 17;91(2):243-52 PMID: 9346241

Product List

Product Name Cat# Quantity Price

Anti MALT1 / Mucosa Associated Lymphoid Tissue 1, Human (Rabbit) Unlabeled DataSheet

KAL-KR067

25 UG ¥49,000
$654

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.


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