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Anti Mouse Semaphorin 4A Monoclonal Antibody


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Background

Semaphorins are a family of phylogenetically conserved soluble and transmembrane proteins. Semaphorins were originally identified as axon guidance factors during neuronal development. Semaphorins are now known to be widely expressed mediators that play significant roles in immune responses and organ morphogenesis.
 The class IV semaphoring subfamily member, Sema4A was identified originally as a semaphorin expressed in developing embryos, and Sema4A transcript levels increase gradually throughout embryonic development. Sema4A is expressed in the brain, lung, kidney, testis, and spleen of adults. In the immune system, Sema4A is preferentially expressed by bone marrow-derived and splenic dendritic cells (DCs), but not by resting T cells. Expression of Sema4A also becomes detectable on the cell surface of T cells following activation.
 Sema4A regulates T-cell-mediated immune responses by interacting with its receptor Tim-2, which is expressed on TH2 cells as a negative regulator. Sema4A expression is specifically induced on the cell surface of TH1 cells during helper T-cell differentiation. T-cell derived Sema4A is necessary for regulating T-cell differentiation. Sema4A expressed on endothelial cells, directly binds to Plexin-D1 and negatively regulates VEGF-dependent vascular formation.
It is also suggested that Sema4A is critically involved in the development of myocarditis and dilated cardiomyopathy.

Application

WB Not tested
IHC Not tested
ICC Not tested
ELISA 1.0-10 μg/mL
FCM 50 ng/mL
Neutralization Not tested
IP 5.0 μg/mL

Character

Primary Source -
Type Monoclonal
Immunogen Peptide of mouse Sema4A extracellular domain
Raised in Sema4A deficient mouse
Myeloma P3U1
Clone number HIAT-2
Isotype IgG1κ
Source Serum-free medium
Purification notes ProteinG
Cross Reactivity Human
Concentration 0.25 mg/mL
Contents(Volume) 25 μg(100 μL/vial)
Label Unlabeled
Buffer PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]
Storage Store below –20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided.

<Reference>
1. Kumanogoh A.. et al.: The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Nature 2002 Oct 10;419(6907):629-33.

Product List

Product Name Cat# Quantity Price

Anti Semaphorin 4A, Mouse (Mouse) Unlabeled DataSheet

KAL-KO401

25 UG ¥55,000
$734

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