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Anti Mouse Semaphorin 7A Monoclonal Antibody


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Background

Semaphorins are a family of phylogenetically conserved soluble and transmembrane proteins. Semaphorins were originally identified as axon guidance factors during neuronal development. Semaphorins are now known to be widely expressed mediators that play significant roles in immune responses and organ morphogenesis.
 Sema7A (also known as CD108) is a glycosylphosphatidylinositol-anchored semaphorin homologous to AHVsema. Sema7A was originally discovered as the John-Milton-Hagen human blood group antigen. Sema7A specially binds to VESPR/CD232/plexin-C1, which confirm that semaphorin is cellular counterpart of AHVsema. Sema7A transcripts are detectable in the embryonic nervous system and in adult tissues, including the brain, spinal cord, lung, and secondary lymphoid organs. Among lymphocyte populations, Sema7A is expressed mainly in activated T cells.
 Sema7A promotes axon outgrowth through beta-1-integrin receptors and contributes to the formation of the lateral olfactory tract. Sema7A expressed on activated T cells stimulates macrophages to produce proinflammatory cytokines through the alpha-1beta-1 integrin.
Sema7A-deficient mice are defective in T cell-mediated immune responses such as contact hypersensitivity and EAE.

Application

WB Not tested
IHC Not tested
ICC Not tested
ELISA 1.0-10 μg/mL
FCM 50 ng/mL
Neutralization Not tested
IP 5.0 μg/mL

Character

Primary Source -
Type Monoclonal
Immunogen Peptide of mouse Sema7A extracellular domain
Raised in Sema7A deficient mouse
Myeloma P3U1
Clone number SKK-7
Isotype IgG1κ
Source Serum-free medium
Purification notes ProteinG
Cross Reactivity Human
Concentration 0.25 mg/mL
Contents(Volume) 25 μg(100 μL/vial)
Label Unlabeled
Buffer PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]
Storage Store below –20°C.Once thawed, store at 4°C. Repeated freeze-thaw cycles should be avoided.

<Reference>
1. Suzuki K. et al.: Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature 2007 Apr 5;446(7136):680-4. Epub 2007 Mar 21.

Product List

Product Name Cat# Quantity Price

Anti Semaphorin 7A, Mouse (Mouse) Unlabeled DataSheet

KAL-KO402

25 UG ¥55,000
$734

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