Anti Mouse Usp11 Polyclonal Antibody


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Background

Usp11 (ubiquitin specific peptidase 11) is possesses Cys box, His box, Asp and KRF domains, which are highly conserved in many ubiquitin-specific proteases. Usp11 is a ubiquitous protein in various tissues and is primarily localized in the nucleus of non-dividing cells. Usp11 binds specifically to RanBPM which is a RanGTP-binding protein required for correct nucleation of microtubles and inhibits its ubiquitination and degradation. It has been also shown that Usp11 is involved in regulation of the TNFα-induced IKKα → p53 signaling pathway and that Usp11 functions in stabilizing HPV-16E7 by reducing ubiquitination and attenuating E7 degradation.

WB Not tested
IHC 5.0-10 μg/mL
ICC Not tested
ELISA Not tested
FCM Not tested
Neutralization Not tested
IP Not tested

<Immunohistochemistry>

SampleFMouse kidney
(paraffin section)


SampleFMouse epididymis
(paraffin section)

Character

Primary Source MGI:2384312
Type Polyclonal
Immunogen Partial peptide of Mouse Usp11
Raised in Rabbit
Myeloma  
Clone number  
Isotype  
Source Rabbit serum
Purification notes Antigen Affinity
Cross Reactivity Not yet tested in other species.
Concentration 0.25 mg/mL
ContentsiVolumej 25μgi100 μL/vialj
Label Unlabeled
Buffer PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]
Storage Store below 20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided.

<Reference>
1. Ideguchi H. et al.: Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. Biochem J. 2002 Oct 1;367(Pt 1):87-95.
2. Yamaguchi T. et al.: The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha).
J Biol Chem. 2007 Nov 23;282(47):33943-8. Epub 2007 Sep 26.
3. Lin CH. et al.: USP11 stabilizes HPV-16E7 and further modulates the E7 biological activity. J Biol Chem. 2008 Jun 6;283(23):15681-8. Epub 2008 Apr 11.

Product List

Product Name Cat# Quantity Price

Anti Usp11, Mouse (Rabbit) Unlabeled DataSheet

KAL-KG403

25 UG ¥49,000
$654

“Anti Mouse Usp11 Polyclonal Antibody” also belongs to the following categories.