Anti Mouse Haao Polyclonal Antibody


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Background

Haao (3-hydroxyanthranilate 3,4-dioxygenase), also known as 3HAO, is a biosynthetic enzyme of quinolinic acid (QUIN). QUIN, a natural brain constituent, is a structural analogue of neurotransmitters such as L-glutamate and L-aspartate, and acts as an excitotoxin through NMDA receptors in neuron of central nervous system. The level of 3HAO expression and QUIN are high in the brain of the El mice which are established animal model for human epilepsy, and the increased production of QUIN is secondary to an increased activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO) in the brain of these mice. In human, the activity of 3HAO is higher in the brains of patients with Huntington chorea than in control brains.

Application

WB Not tested
IHC 5.0-10 μg/mL
ICC Not tested
ELISA Not tested
FCM Not tested
Neutralization Not tested
IP Not tested

<Immunohistochemistry>

SampleFMouse liver (polyester wax section)

Character

Primary Source MGI:1349444
Type Polyclonal
Immunogen Partial peptide of Mouse Haao
Raised in Rabbit
Myeloma  
Clone number  
Isotype  
Source Rabbit serum
Purification notes Antigen Affinity
Cross Reactivity Not yet tested in other species.
Concentration 0.25 mg/mL
Contents(Volume) 25 μg(100 μL/vial)
Label Unlabeled
Buffer PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]
Storage Store below –20°C. Once thawed, store at 4°C. Repeated freeze-thaw cycles should be avoided.

<Reference>
1. Nakano,K. et al.: Abnormally high activity of 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice. Brain Res. 1992 572 (1-2), 1-4
2. Eastman,C.L. et al.: Differential expression of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase and glutamine synthetase in seizure-prone and non-epileptic mice. Epilepsy Res. 1994 18 (3), 185-194
3. Nakagawa,Y. et al.: Increased expression of 3-hydroxyanthranilate 3,4-dioxygenase gene in brain of epilepsy-prone El mice. Brain Res. 1998 Mol. Brain Res. 58 (1-2), 132-137

Product List

Product Name Cat# Quantity Price

Anti Haao, Mouse (Rabbit) Unlabeled DataSheet

KAL-KG408

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$654

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