Anti Mouse Trpm2 Polyclonal Antibody


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Background

Function : Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity.
Tissue specificity : Widely expressed, with highest levels in lung, spleen, eye and brain.
Sequence similarities : Belongs to the transient receptor family. LTrpC subfamily. Contains 1 nudix hydrolase domain.

Application

Catalog number : KAL-KO462
ELISA WB IHC ICC
1.0 μg/mL Not tested Not tested 1.0-5.0 μg/mL
IP FCM IF Neutralization
Not tested Not tested Not tested Not tested
Catalog number : KAL-KO463
ELISA WB IHC ICC
1.0 μg/mL 1.0-5.0 μg/mL 5.0-10 μg/mL 1.0-5.0 μg/mL
IP FCM IF Neutralization
Not tested Not tested Not tested Not tested

Character

Type Polyclonal Antibody
Immunogen Partial peptide of Mouse Trpm2 middle region
Raised in Rabbit
Source Rabbit Serum
Purification notes Antigen Affinity
Cross Reactivity Human, Rat (KAL-KO463)
Concentration 0.25 mg/mL
Contents (Volume) 25 μg (100 μL/vial)
Label Unlabeled
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Storage Store below -20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided.

<Reference>
1. Kaneko S, et al. A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci. 2006 May;101(1):66-76. *Application Reference
2. Hara Y, et al. LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell. 2002 Jan;9(1):163-73.
3. Togashi K, et al. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J. 2006 May 3;25(9):1804-15. *Application Reference
4. Yamamoto S, et al. TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med. 2008 Jul;14(7):738-47. *Application Reference

Product List

Product Name Cat# Quantity Price

Anti Trpm2, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO462

25 UG ¥49,000
$654

Anti Trpm2, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO463

25 UG ¥49,000
$654

Thermosensitive TRP Channel Related antibodies


Product Name Cat# Quantity Price

Anti TRPV1 / VR-1, Rat (Rabbit) Unlabeled DataSheet

KAL-KM018

5 UG ¥49,000
$654

Anti TRPV2 / VRL-1, Rat (Rabbit) Unlabeled DataSheet

KAL-KM019

5 UG ¥49,000
$654

Anti TRPM8 / CMR1, Rat (Rabbit) Unlabeled DataSheet

KAL-KM060

25 UG N/A

Anti TRPV1 / VR-1, phospho Ser800, Rat (Rabbit) Unlabeled DataSheet

KAL-KM112

25 UG ¥49,000
$654

Anti TRPV 4, Rat (Rabbit) Unlabeled DataSheet

KAL-KM119

25 UG ¥49,000
$654

Anti TRPA 1, Mouse (Rabbit) Unlabeled DataSheet

KAL-KM120

50 UG ¥49,000
$654

Anti Rim1, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO454

25 UG ¥49,000
$654

Anti Cacnb4, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO455

25 UG ¥49,000
$654

Anti Trpc3, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO456

25 UG ¥49,000
$654

Anti Trpc3, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO457

25 UG ¥49,000
$654

Anti Trpc5, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO458

25 UG ¥49,000
$654

Anti Trpc5, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO459

25 UG ¥49,000
$654

Anti Trpc6, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO460

25 UG ¥49,000
$654

Anti Trpm1, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO461

25 UG ¥49,000
$654

Anti Trpm2, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO462

25 UG ¥49,000
$654

Anti Trpm2, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO463

25 UG ¥49,000
$654

Anti Trpm7, Mouse (Rabbit) Unlabeled DataSheet

KAL-KO464

25 UG ¥49,000
$654

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.



“Anti Mouse Trpm2 Polyclonal Antibody” also belongs to the following categories.