Anti Human CCR5 Polyclonal Antibody


print

Application

ELISA WB IHC ICC
- 1.0 - -
IP FCM IF Neutralization
- 1.0 - -


[WB] CCR5 transfected 293T cell lysate


[FCM]  CCR5 expressing 293 cells

<Summary>
#. Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
#  Subcellular location: Cell membrane; Multi-pass membrane protein.
#  Tissue specificity: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1A and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
#  Sequence similarities: Belongs to the G-protein coupled receptor 1 family

Feature and Advantages

Type Polyclonal Antibody
Immunogen Recombinant protein of full length Human CCR5
Raised in mouse
Source Mouse Serum
Purification Protein A purified
Cross Reactivity  
Concentration 0.5 mg/mL
ContentsiVolumej 50 μg
Label Unlabeled
Buffer PBS, pH 7.2
Storage Store at - 20Ž long term, store at 4Ž short term. Avoid repeated freeze-thaw cycles.

<Reference>
1. Samson M., et al.  "Molecular cloning and functional expression of a new human CC-chemokine receptor gene." Biochemistry 35:3362-3367(1996) 
2. Raport C.J., et al.  "Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha." J. Biol. Chem. 271:17161-17166(1996)
3. Combadiere C., et al.  "Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES." J. Leukoc. Biol. 60:147-152(1996)

Product List

Product Name Cat# Quantity Price

Anti CCR5, Human (Mouse) Unlabeled DataSheet

KAL-KB488

50 UG N/A

“Anti Human CCR5 Polyclonal Antibody” also belongs to the following categories.