useful to a general oxidative stress marker in the body.

DNA-damage Biomarker 8-OHdG "8-OHdG Check"


"8-OHdG Check" is a competitive in vitro enzyme-linked immunosorbent assay for quantitative measurement of the oxidative DNA adducts 8-hydroxy-2'-deoxyguanosine (8-OHdG) in various biological samples such as DNA of tissue, serum, urine etc., using anti-8-OHdG monoclonal antibody.

How to check the oxidative stress and how it influences human health?

1. Oxidative stress causes diseases including cancer and aging.
Currently there is a strong scientific opinion that more than 90 percent of diseases are caused by oxidative stress due to active oxygen, other free radicals and lipid peroxides. Active oxygen, though vital to our body, causes considerable damage to the essential components of human body and disturbs the physiologically important functions of proteins, lipids, enzymes and DNA bearing the genetic code. This leads to disorder in our body, which in turn leads to development of diseases and accelerating aging. It has been demonstrated that oxidative stress causes cancers and many 'life-style related diseases such as arterial sclerosis, high blood pressure, myocardial infarction, cerebral apoplexy, dementia, diabetes, cataract etc.

2. What is 8-OHdG?
It has been calculated that about 2 percent of oxygen inhaled by the respiratory system turn to active oxygen in human body. This can reach to 10 percent in worse case scenario. Active oxygen is produced when our body generates energy and also when microphage cells confronts foreign, invading substances which may cause harm to the body and dispose them appropriately in our body system. Thus, active oxygen is essential and useful to our body. However, danger occurs when excess active oxygen is dispersed and which becomes detrimental to organs, body tissues and blood corpuscles.
Deoxyguanosine (dG) is one of the constituents of DNA and when it is oxidized, it is altered into 8-hydroxy-2'-deoxyguanosine (8-OHdG).


Oxidative Stress Markers flyer download [PDF]

New 8-OHdG Check ELISA KIT

8-hydroxy-2'-deoxyguanosine (8-OHdG / 8-oxo-dG) ELISA kit
product number : NNS-KOG-200SE-EX

New 8-OHdG Check ELISA KIT/Trial Package

8-hydroxy-2'-deoxyguanosine (8-OHdG / 8-oxo-dG) ELISA kit Trial Package
product number : NNS-KOG-200TE-EX

Highly Sensitive 8-OHdG Check ELISA KIT

8-hydroxy-2'-deoxyguanosine (8-OHdG / 8-oxo-dG) ELISA kit
Lower concentration of 8-OHdG can be measured with this kit.
product number : NNS-KOG-HS10E-EX

Anti 8-OHdG monoclonal antibody

product number : NNS-MOG-020P-EX
product number : NNS-MOG-100P-EX

8-Hydroxy-2'-deoxyguanosine >>
Epidermis from hairless mouse by chronic UVB irradiation after 4 weeks of treatment stained with N45.1.

Sample pretreatment procedure

References and Technical Information

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