High-quality antibody necessary for transcriptional control signal

Anti human CAR mouse monoclonal antibody


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CAR : Constitutive androstane receptor

Background

CAR (NR1I3) is a member of orphan receptor. CAR is mainly expressed in liver and lower levels of expression are observed in heart, muscles, kidney and lung. CYP3A and CYP2B are regulated by CAR, which suggest xenobiotics can activate multiple CYP genes through this receptor. Mouse homolog is induced by phenobarbital and CAR-null mouse resistance to acetaminophen toxicity. CAR affects metabolism of drugs and other xenobiotics.

Application

<Recommended Concentration>
In order to obtain the best results, optimal working dilutions should be determined by each individual user.

Western Blot : 1 ug/mL
Non reducing Western Blot : 3 ug/mL
ELISA : 0.1 ug/mL (A450=0.2)
Immunoprecipitation : Decide by use
Supershift Assay : Not yet tested
Chromatin immunoprecipitation : Not yet tested
Immunohistochemistry : Decide by use


Rat / Cerebellum

Specificity

This antibody specifically recognizes human CAR and cross reacts with mouse and rat CAR. This antibody does not recognize human PXR.

Product List

Product Name Cat# Quantity Price

Anti CAR, Human (Mouse)  DataSheet

PPX-PP-N4111-00

0.1 ML ¥50,000
$667

“Anti human CAR mouse monoclonal antibody” also belongs to the following categories.