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regulatory T cells can be sorted alive to investigate the functions

Anti FR4(Folate Receptor 4) Antibody / Treg-marker


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Background

Regulatory T cells are important for immune tolerance and perform adverse immunoreaction, compared with activated T cells. The discrimination between the regulatory T cells and the activated T cells is very important for immunology research. Although Foxp3 is well-known as an intracellular marker of regulatory T cell, it is inevitable that the regulatory T cell cannot be maintained alive after the reaction with Foxp3.
Folate receptor 4 is newly found to be a highly expressed surface marker of the regulatory T cells. The anti mouse- regulatory T cell antibody can react specifically with the surface marker. When the antibody is used for regulatory T cells instead of Foxp3, the cell can be sorted alive to investigate the functions.

Experiment example


Flow Cytometry Analysis
Detection of cell membrane mouse folate receptor 4(TH6) in spleen of mouse.
Cells were stained by using PE-conjugated anti-mouse CD25, APC-conjugated anti-mouse CD4 mouse, and the folate receptor4 antibody & anti-rat IgG FITC conjugated.
Flow cytometry was performed on a FACS Vantage SETM.

 

<Reference>
T Ymaguchi,K Hirota et al.:Control of Immune Responses by Antigen-Specific Regulatory T Cells Expressing the Folate Receptor. Immunity 27,1-5, July 2007

Product List

Product Name Cat# Quantity Price

Anti Folate Receptor 4(Treg-marker), Mouse (Rat) Unlabeled DataSheet

REC-RCAB012M-F

100 UL N/A

Anti Folate Receptor 4(Treg-marker), Mouse (Rat) Biotin DataSheet

REC-RCAB012M-FB

100 UL N/A

Anti Folate Receptor 4(Treg-marker), Mouse (Rat) Fluorescein Isothiocyanate DataSheet

REC-RCAB012M-FF

100 UL N/A

Anti Folate Receptor 4(Treg-marker), Mouse (Rat) Unlabeled DataSheet

REC-RCAB013M-F

100 UL N/A

Anti Folate Receptor 4(Treg-marker), Mouse (Rat) Biotin DataSheet

REC-RCAB013M-FB

100 UL N/A

Anti Folate Receptor 4(Treg-marker), Mouse (Rat) Fluorescein Isothiocyanate DataSheet

REC-RCAB013M-FF

100 UL N/A

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.


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