Tools for Cancer Research

Antibodies to Human Tumor Markers


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Background

Circulating tumor markers secreted or shed by cancer cells and monitored in blood, urine, or other fluids have been variously evaluated for their utility in aiding early diagnosis, determining prognosis, predicting response to cancer therapy, patient surveillance after initial therapy, and monitoring response to therapy in advanced cancers. In addition, immunohistochemical evaluation of biopsied tissue to detect tumor marker expression and levels are often studied for their ability to distinguish between normal and cancerous cells and for their value in assessing tumor cell origin.  Clinically, the primary utility of alfa-fetoprotein (AFP) has been in following the response to treatment for hepatocellular carcinoma. Prostatic acid phosphatase (PAP) has been used in prostate cancer, though less effectively than prostate-specific antigen (PSA). Carcinoembryonic antigen (CEA) is widely used to follow the progression of colorectal cancer. Though less well established as a tumor marker, research on ferritin is ongoing.

Product List

AFP[alpha-fetoprotein]

AFP is a major plasma protein in the fetus (produced in the yolk sac and fetal liver). In normal adults, very low levels are detected but these may rise substantially due to certain cancers or other physiologic conditions including liver cancers, yolk sac tumor, hepatitis, hepatic cirrhosis, and late pregnancy.


Product Name Cat# Quantity Price

Anti AFP, Human (Mouse) Unlabeled DataSheet

SIM-2ZHCMA1

0.5 ML ¥44,000
$587

Anti AFP, Human (Mouse) Unlabeled DataSheet

SIM-2ZHCMA2

0.5 ML ¥44,000
$587

Anti AFP, Human (Mouse) Unlabeled DataSheet

SIM-2ZHCMA3

0.5 ML ¥44,000
$587

[SIM-2ZHCMA1] Specificity F Antigenic determinant a

[SIM-2ZHCMA2] Specificity F Antigenic determinant b

[SIM-2ZHCMA3] Specificity F Antigenic determinant c

CEA[carcinoembryonic antigen]

CEA was originally identified in colon cancer tissue and later shown to be a cell adhesion molecule detected in embryos but not in most normal adults. CEA in blood is widely used in the management of colorectal cancers and to a lesser extent in breast, ovarian, and lung cancers. CEA levels may be high in otherwise healthy heavy smokers.


Product Name Cat# Quantity Price

Anti CEA, Human (Mouse) Unlabeled DataSheet

SIM-2ZHCMC1

0.5 ML ¥44,000
$587

Anti CEA, Human (Mouse) Unlabeled DataSheet

SIM-2ZHCMC2

0.5 ML ¥44,000
$587

[SIM-2ZHCMC1] Specificity F CEA+, NCA+, NCA‡U+

[SIM-2ZHCMC2] Specificity F CEA+,NCA-, NCA‡U+

PAP[prostatic acid phosphatase]

PAP is produced in prostate and is often elevated in prostate cancers. The use of PAP in prostate cancer management has been largely supplanted by PSP. In 2007, PAP fragments, abundant in semen, were found to produce amyloid fibrils that can dramatically enhance HIV infection. PAP may therefore become a therapeutic target for reducing HIV infection.  PMID: 18083097


Product Name Cat# Quantity Price

Anti PAP, Human (Mouse) Unlabeled DataSheet

SIM-2ZHCMP1

0.5 ML ¥44,000
$587

Anti PAP, Human (Mouse) Unlabeled DataSheet

SIM-2ZHCMP2

0.5 ML ¥44,000
$587

Ferritin

Ferritin is the main depot for storage of free iron, which is otherwise toxic to cells. Serum Ferritin level is a sensitive marker for iron deficiency anemia and other iron metabolism related diseases. As a tumor marker, elevated ferritin levels have been associated with several types of cancer including malignant lymphoma, squamous cell cancers of the head and neck, and renal cell carcinomas, though its use is not currently widespread.


Product Name Cat# Quantity Price

Anti Ferritin, Human (Mouse) Unlabeled DataSheet

SIM-2ZHCMF1

0.5 ML ¥44,000
$587

Anti Ferritin, Human (Mouse) Unlabeled DataSheet

SIM-2ZHCMF2

0.5 ML ¥44,000
$587

“Antibodies to Human Tumor Markers” also belongs to the following categories.