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useful for the research of the diabetic and arteriosclerosis.

Reagents for the Renin-Angiotensin System [RAS]


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Anti Human Angiotensin I Polyclonal Antibody
Anti Human Prorenin Polyclonal Antibodies
Anti Human Prorenin Monoclonal Antibody

Background

Prorenin is the enzymatically inactive biosynthetic precursor (pro-form) of renin, the pivotal factor of the renin-angiotensin system (RAS) that regulates blood pressure and fluid balance.  The “mature-active” renin is secreted from the juxtaglomerular cells after the processing of the N-terminal “pro”-segment from the prorenin molecule.  The plasma level of prorenin is 5 to 10-times higher than that of renin. (1-3) 
It was reported that the plasma prorenin level was elevated in the patients of diabetic complications (such as the diabetic nephropathy and the diabetic retinopathy) and in the pregnant women. (5-9)

<Reference>
1) Sealey JE, Laragh JH. Circ. Res. (1975) 36(6 Suppl 1):10-16. [Pubmed]
2) Luetscher JA. et al. N. Engl. J. Med. (1985) 312(22):1412-17. [Pubmed]
3) Hsueh WA, Baxter JD. Hypertension (1991) 17(4):469-77. [Pubmed]
4) Suzuki, F. et al. Biosci. Biotechnol. Biochem. 63(3):550-54. [Pubmed]
5) Minagawa S. et al. Nippon Rinsho. (2002) 60(Suppl10):108-14. [Pubmed]
6) Kawazu S. et al. J. Diabetes Complicat. (2004) 18(5):275-81. [Pubmed]
7) Allen TJ. et al. Kidney Int. (1996) 50(3):902-7. [Pubmed]
8) Danser AH. et al. J. Hypertens. (1998) 16(6):853-62. [Pubmed]
9) Cugini P. et al. Clin. Exp. Obstet. Gynecol. (1982) 9(4):226-32. [Pubmed]

Product List

Product Name Cat# Quantity Price

Anti Angiotensin I, Human (Rabbit) Unlabeled DataSheet

PRX-PR40-AGT01SR

100 UL N/A

Anti Prorenin, Human (Rabbit) Unlabeled DataSheet

PRX-PR40-PRN01PA

100 UG N/A

Anti Prorenin, Human (Rabbit) Unlabeled DataSheet

PRX-PR40-PRN01SR

100 UL N/A

Anti Prorenin, Human (Rabbit) Unlabeled DataSheet

PRX-PR40-PRN02SR

100 UL N/A

Anti Prorenin, Human (Mouse) Unlabeled DataSheet

PRX-PR40-PRN03

100 UG N/A

Product Name Cat# Quantity Price

Prorenin, Human DataSheet

PRX-PR50-HPCH

100 UG N/A

Prorenin, Human DataSheet

PRX-PR50-HPRN

100 UG N/A

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