記事ID ： 13702

AMPK（A1／B1／G3）（Subunit A1: PRKAA1, MGC33776, MGC57364 Subunit B1: PRKAB1, AMPK, HAMPKb, MGC17785 Subunit G3: PRKAG3） Active Kinase AMPK（A1／B1／G3）活性型キナーゼ

カテゴリから探す > シグナル伝達 > リン酸化／ユビキチン化／SUMO化 > プロテインキナーゼ > セリンスレオニンキナーゼ

メーカー名：SignalChem Pharmaceuticals,Inc.

AMP活性化型タンパク質キナーゼ(AMPK)は細胞のエネルギー恒常性において主要な調節因子として作用する重要なエネルギー感受性酵素群である。AMPKは触媒性のα鎖部ユニットと制御性のβとγサブユニットからなるヘテロ三量体複合体として存在する。AMPがγサブユニットに結合すると、本複合体がアロステリックに活性化される。AMPKは、細胞のATPを枯渇させるストレス(低グルコース、低酸素、虚血)に応答してエネルギー状態を監視する。また、アディポネクチン、レプチン、CAMKKβに応答してそのシグナル伝達経路を介して活性化され、主な律速酵素であるアセチルCoAカルボキシラーゼとヒドロキシβメチルグルタリルCoA還元酵素を制御することで、脂肪酸とコレステロールの生合成を調節する。γサブユニットは骨格筋で高発現し、エネルギー代謝の調節に主要な役割を担うと考えられる。

AMPK（A1／B1／G3）キナーゼ・関連製品対応表

活性型キナーゼ		ペプチド基質		タンパク質基質		抗体		阻害剤
品名	品番	品名	品番	品名	品番	品名	品番	品名	品番
AMPK (A1/B1/G1), Active	P47-10H	SAMStide	S07-58			Anti-AMPK alpha 1 Anti-AMPK alpha 1/2	P47-63R P47-63BR	AICAR PKC-412 Apigenin K252A K252B Staurosporine	P47-900B K10-900B K10-900C K10-900D K10-900E K10-900
AMPK (A1/B1/G2), Active	P55-10H
AMPK (A1/B1/G2), Active	P55-10G
AMPK (A1/B1/G3), Active	P56-10H
AMPK (A1/B1/G3), Active	P56-10G
AMPK (A1/B2/G1), Active	P50-10H
AMPK (A1/B2/G1), Active	P50-10G
AMPK (A1/B2/G2), Active	P45-10G
AMPK (A1/B2/G3), Active	P83-10G
AMPK (A2/B1/G1), Active	P48-10H					Anti-AMPK alpha 1/2	P47-63BR
AMPK (A2/B1/G2), Active	P84-10GH
AMPK (A2/B1/G3), Active	P85-10GH
AMPK (A2/B2/G1), Active	P49-10GH
AMPK (A2/B2/G1), Active	P49-10H
AMPK (A2/B2/G2), Active	P54-10GH
AMPK (A2/B2/G2), Active	P54-10H
AMPK (A2/B2/G3), Active	P46-10GH

AMPK（A1／B1／G3）活性型キナーゼ

AMPK（A1／B1／G3）（Subunit A1: PRKAA1, MGC33776, MGC57364 Subunit B1: PRKAB1, AMPK, HAMPKb, MGC17785 Subunit G3: PRKAG3） Active Kinase

品名	メーカー	品番	包装	希望販売価格
AMPK (A1/B1/G1), Active, Human	SCP	P47-10H	10 UG	￥157,000
AMPK (A1/B1/G1), Active, Human	SCP	P47-10H	5 UG	￥104,000
AMPK (A1/B1/G2), Active, Human	SCP	P55-10H	10 UG	￥157,000
AMPK (A1/B1/G2), Active, Human	SCP	P55-10H	5 UG	￥104,000
AMPK (A1/B1/G2), Active, Human	SCP	P55-10G	10 UG	￥157,000
AMPK (A1/B1/G2), Active, Human	SCP	P55-10G	5 UG	￥104,000
AMPK (A1/B1/G3), Active, Human	SCP	P56-10H	10 UG	￥157,000
AMPK (A1/B1/G3), Active, Human	SCP	P56-10H	5 UG	￥104,000
AMPK (A1/B1/G3), Active, Human	SCP	P56-10G	10 UG	￥157,000
AMPK (A1/B1/G3), Active, Human	SCP	P56-10G	5 UG	￥104,000
AMPK (A1/B2/G1), Active, Human	SCP	P50-10H	10 UG	￥157,000
AMPK (A1/B2/G1), Active, Human	SCP	P50-10H	5 UG	￥104,000
AMPK (A1/B2/G1), Active, Human	SCP	P50-10G	10 UG	￥157,000
AMPK (A1/B2/G1), Active, Human	SCP	P50-10G	5 UG	￥104,000
AMPK (A1/B2/G2), Active, Human	SCP	P45-10G	10 UG	￥157,000
AMPK (A1/B2/G2), Active, Human	SCP	P45-10G	5 UG	￥104,000
AMPK (A1/B2/G3), Active, Human	SCP	P83-10G	10 UG	￥157,000
AMPK (A1/B2/G3), Active, Human	SCP	P83-10G	5 UG	￥104,000
AMPK (A2/B1/G1), Active, Human	SCP	P48-10H	10 UG	￥157,000
AMPK (A2/B1/G1), Active, Human	SCP	P48-10H	5 UG	￥104,000
AMPK (A2/B1/G2), Active, Human	SCP	P84-10GH	10 UG	￥157,000
AMPK (A2/B1/G2), Active, Human	SCP	P84-10GH	5 UG	￥104,000
AMPK (A2/B1/G3), Active, Human	SCP	P85-10GH	10 UG	￥157,000
AMPK (A2/B1/G3), Active, Human	SCP	P85-10GH	5 UG	￥104,000
AMPK (A2/B2/G1), Active, Human	SCP	P49-10GH	10 UG	￥157,000
AMPK (A2/B2/G1), Active, Human	SCP	P49-10GH	5 UG	￥104,000
AMPK (A2/B2/G1), Active, Human	SCP	P49-10H	10 UG	￥157,000
AMPK (A2/B2/G1), Active, Human	SCP	P49-10H	5 UG	￥104,000
AMPK (A2/B2/G2), Active, Human	SCP	P54-10GH	10 UG	￥157,000
AMPK (A2/B2/G2), Active, Human	SCP	P54-10GH	5 UG	￥104,000
AMPK (A2/B2/G2), Active, Human	SCP	P54-10H	10 UG	￥157,000
AMPK (A2/B2/G2), Active, Human	SCP	P54-10H	5 UG	￥104,000
AMPK (A2/B2/G3), Active, Human	SCP	P46-10GH	10 UG	￥157,000
AMPK (A2/B2/G3), Active, Human	SCP	P46-10GH	5 UG	￥104,000

AMPK（A1／B1／G3）キナーゼ／種由来・タグ・発現系詳細

品番	品名	種由来	タグ	発現系	配列
P47-10H	AMPK (A1/B1/G1), Active	Human	His (C-term)	Sf9	Full Length
P55-10H	AMPK (A1/B1/G2), Active	Human	His (C-term)	Sf9	Full Length
P55-10G	AMPK (A1/B1/G2), Active	Human	His (C-term) GST(N-term)	Sf9	Full Length
P56-10H	AMPK (A1/B1/G3), Active	Human	His (C-term)	Sf9	Full Length
P56-10G	AMPK (A1/B1/G3), Active	Human	His (C-term) GST(N-term)	Sf9	Full Length
P50-10H	AMPK (A1/B2/G1), Active	Human	His (C-term)	Sf9	Full Length
P50-10G	AMPK (A1/B2/G1), Active	Human	His (C-term) GST(N-term)	Sf9	Full Length
P45-10G	AMPK (A1/B2/G2), Active	Human	His (C-term) GST(N-term)	Sf9	Full Length
P83-10G	AMPK (A1/B2/G3), Active	Human	His (C-term) GST(N-term)	Sf9	Full Length
P48-10H	AMPK (A2/B1/G1), Active	Human	His (C-term)	Sf9	Full Length
P84-10GH	AMPK (A2/B1/G2), Active	Human	His (C-term) GST(N-term)	Sf9	Full Length
P85-10GH	AMPK (A2/B1/G3), Active	Human	His (C-term) GST(N-term)	Sf9	Full Length
P49-10GH	AMPK (A2/B2/G1), Active	Human	His (C-term) GST(N-term)	Sf9	Full Length
P49-10H	AMPK (A2/B2/G1), Active	Human	His (C-term)	Sf9	Full Length
P54-10GH	AMPK (A2/B2/G2), Active	Human	His (C-term) GST(N-term)	Sf9	Full Length
P54-10H	AMPK (A2/B2/G2), Active	Human	His (C-term)	Sf9	Full Length
P46-10GH	AMPK (A2/B2/G3), Active	Human	His (C-term)	Sf9	Full Length

ペプチド基質

品名	メーカー	品番	包装	希望販売価格
SAMStide, Mouse	SCP	S07-58	1 MG	￥20,000

抗体

品名	メーカー	品番	包装	希望販売価格
Anti AMPK α 1, Human (Rabbit)	SCP	P47-63R	100 UG	￥83,000
Anti AMPK α 1/2, Human (Rabbit)	SCP	P47-63BR	100 UG	￥65,000

阻害剤

品名	メーカー	品番	包装	希望販売価格
AICAR	SCP	P47-900B	50 MG	￥18,000
PKC-412	SCP	K10-900B	5 MG	￥167,000
Apigenin	SCP	K10-900C	50 MG	￥68,000
K252A	SCP	K10-900D	1 MG	販売終了
K252B	SCP	K10-900E	1 MG	￥186,000
Staurosporine	SCP	K10-900	1 MG	￥18,000