バイオマーカー研究に最適な各種変異 cDNA Clone Mutant / Variant cDNA クローン

〈キナーゼ欠損変異クローン〉 ・ M. Varjosalo, et al . Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell. 133, 536-548 （2008）. 〈HRAS変異クローン〉 ・ Y. Aoki, et al. Germline mutations in HRAS proto-oncogene cause Costello syndrome. Nat Genet. 37, 1038-1040 （2005）. ・ E. Sakai, et al . The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma. Int J Cancer. 52, 867-872 （1992）. 〈IDH1変異クローン〉 ・ H. Yan, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 360, 765-773 （2009）. 〈IDH2変異クローン〉 ・ H. Yan, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 360, 765-773 （2009）. 〈KRAS変異クローン〉 ・ L. Gremer, et al . Germline KRAS mutations cause aberrant biochemical and physicalproperties leading to developmental disorders. Hum Mutat. 32, 33-43 （2011）. ・ SH. Lee, et al. BRAF and KRAS mutations in stomach cancer. Oncogene. 22, 6942-6945 （2003）. 〈NRAS変異クローン〉 ・ C. Gambke, et al. Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon. Proc Natl Acad Sci U S A. 82, 879-882 （1985）. 〈TP53変異クローン〉 ・AA. Ahmed, et al. Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary. J Pathol. 221, 49-56 （2010）.