細胞質チロシンキナーゼ(Cytoplasmic Tyrosine Kinases)を各種販売しております。
SignalChem社 高精製度 キナーゼ トップへ戻る細胞質チロシンキナーゼを各種販売 高精製度キナーゼ - Cytoplasmic Tyrosine Kinases
- カテゴリから探す > シグナル伝達 > リン酸化/ユビキチン化/SUMO化 > プロテインキナーゼ
- 研究分野から探す > がん研究 > リン酸化の検出・測定 > リコンビナントキナーゼ
背景
細胞質チロシンキナーゼについて
細胞質チロシンキナーゼ(Cytoplasmic Tyrosine Kinase)は、細胞外シグナルの重要な伝達者です。例えば、JAK - STAT経路は、過量のサイトカイン及び成長因子によって活性化されるシグナル経路です。この経路は、増殖、分化、走化性、アポトーシスを調節する役割を果たし、造血及び免疫系の発生に重要です。
Janusキナーゼファミリーは、4つの異なるファミリーメンバー(JAK1、JAK2、JAK3、TYK2)で構成されています。JAK1、JAK2及びTYK2は広範囲に発現し、JAK3は白血球に特異的です。受容体が会合することで、Janusキナーゼはお互いが近接するようになり、トランスリン酸化により活性化されます。これらのキナーゼの活性化は、STAT(シグナル伝達兼転写活性化因子;Signal Transducers and Activators of Transcription)タンパク質及びその類似タンパク質などの多数のタンパク質の、特異的な部位のチロシンのリン酸化を引き起こします。最近、STATファミリーの7種類の異なるメンバー(STAT1、2、3、4、5a、5b、6)が同定されました。
C-末端に位置する保存されたチロシン残基のリン酸化により、STATタンパク質は二量体化し、続いて核へ移動します。この移動は、インポーチンa5及びRan核内輸送経路に依存していることが証明されています。核内で、これらのタンパク質は特異的な遺伝子に結合し、転写を活性化又は抑制します。
JAK-STAT経路は、メカニズムの多くから経路をネガティブに調節する影響を受けます。例えば、レセプターのダウンレギュレーション、JAKとそのレセプターの解離、サイトカインシグナリングの抑制(SOCS)、STATのタンパク質阻害因子、CD45のようなタンパク質チロシンホスファターゼ(PTP)などがあります。
興味深いことに、ある種の白血病で、これらのキナーゼの突然変異が起こっていることが報告されています。例えば、V617F変異は、造血細胞の成長因子に対する感受性を高めます。
高精製度キナーゼ - Cytoplasmic Tyrosine Kinases
品名 | メーカー | 品番 | 包装 | 希望販売価格 |
---|---|---|---|---|
AATK, Mouse | SCP | A02-35G | 20 UG |
¥52,000 |
AATK, Mouse | SCP | A02-35G | 50 UG |
¥104,000 |
ABL1 Mutant (E255K), Active, Human | SCP | A03-12BG | 5 UG |
¥54,000 |
ABL1 Mutant (E255K), Active, Human | SCP | A03-12BG | 10 UG |
¥78,000 |
ABL1 Mutant (G250E), Active, Human | SCP | A03-12CG | 5 UG |
販売終了 |
ABL1 Mutant (G250E), Active, Human | SCP | A03-12CG | 10 UG |
販売終了 |
ABL1 Mutant (T315I), Active, Human | SCP | A03-12DG | 5 UG |
¥54,000 |
ABL1 Mutant (T315I), Active, Human | SCP | A03-12DG | 10 UG |
¥78,000 |
ABL1 Mutant (Y253F), Active, Human | SCP | A03-12EG | 5 UG |
¥54,000 |
ABL1 Mutant (Y253F), Active, Human | SCP | A03-12EG | 10 UG |
¥78,000 |
ABL1, Active, Mouse | SCP | A03-11H | 5 UG |
¥54,000 |
ABL1, Active, Mouse | SCP | A03-11H | 10 UG |
¥78,000 |
ABL1, Active, Human | SCP | A03-18H | 5 UG |
¥54,000 |
ABL1, Active, Human | SCP | A03-18H | 10 UG |
¥78,000 |
ABL2, Active, Human | SCP | A04-11H | 5 UG |
¥54,000 |
ABL2, Active, Human | SCP | A04-11H | 10 UG |
¥78,000 |
ACVR2A, Human | SCP | A35-35H | 20 UG |
販売終了 |
ACVR2A, Human | SCP | A35-35H | 50 UG |
販売終了 |
ACVR2B, Human | SCP | A36-35G | 20 UG |
販売終了 |
ACVR2B, Human | SCP | A36-35G | 50 UG |
販売終了 |
Anti BTK, Human (Rabbit) | SCP | B10-63R | 100 UG |
¥143,000 |
Anti c-Jun, Human (Rabbit) | SCP | C05-63R | 100 UG |
¥65,000 |
Anti JAK2, Human (Rabbit) | SCP | J02-63R | 100 UG |
¥83,000 |
Anti PYK2, Human (Rabbit) | SCP | P92-63R | 100 UG |
¥65,000 |
Anti TYK2 (JTK1), Human (Rabbit) | SCP | T21-63R | 100 UG |
¥143,000 |
Anti UBA2 (SAE2), Human (Rabbit) | SCP | U202-63R | 100 UG |
¥143,000 |
Anti UBE2N (UBC13), Human (Rabbit) | SCP | U231-63R | 100 UG |
¥143,000 |
Anti UBLE1A (SAE1), Human (Rabbit) | SCP | U208-63R | 100 UG |
¥143,000 |
Anti VLK, Human (Rabbit) | SCP | V05-163R | 100 UG |
¥143,000 |
BLK, Active, Human | SCP | B02-10G | 5 UG |
¥54,000 |
BLK, Active, Human | SCP | B02-10G | 10 UG |
¥78,000 |
BMX, Active, Human | SCP | B07-10G | 5 UG |
¥54,000 |
BMX, Active, Human | SCP | B07-10G | 10 UG |
¥78,000 |
BRK, Active, Human | SCP | P94-10G | 5 UG |
¥54,000 |
BRK, Active, Human | SCP | P94-10G | 10 UG |
¥78,000 |
BTK, Active, Human | SCP | B10-10H | 5 UG |
¥54,000 |
BTK, Active, Human | SCP | B10-10H | 10 UG |
¥78,000 |
c-KIT Mutant (D816E), Active, Human | SCP | C06-12IG | 5 UG |
¥54,000 |
c-KIT Mutant (D816E), Active, Human | SCP | C06-12IG | 10 UG |
¥78,000 |
c-KIT Mutant (D816F), Active, Human | SCP | C06-12JG | 5 UG |
¥54,000 |
c-KIT Mutant (D816F), Active, Human | SCP | C06-12JG | 10 UG |
¥78,000 |
c-KIT Mutant (D816H), Active, Human | SCP | C06-12KG | 5 UG |
¥54,000 |
c-KIT Mutant (D816H), Active, Human | SCP | C06-12KG | 10 UG |
¥78,000 |
c-KIT Mutant (D816V), Active, Human | SCP | C06-12LG | 5 UG |
¥54,000 |
c-KIT Mutant (D816V), Active, Human | SCP | C06-12LG | 10 UG |
¥78,000 |
c-KIT Mutant (D816Y), Active, Human | SCP | C06-12MG | 5 UG |
¥54,000 |
c-KIT Mutant (D816Y), Active, Human | SCP | C06-12MG | 10 UG |
¥78,000 |
c-KIT Mutant (T670I), Active, Human | SCP | C06-12FG | 5 UG |
¥54,000 |
c-KIT Mutant (T670I), Active, Human | SCP | C06-12FG | 10 UG |
¥78,000 |
c-KIT Mutant (V559A), Active, Human | SCP | C06-12OG | 5 UG |
¥54,000 |
c-KIT Mutant (V559A), Active, Human | SCP | C06-12OG | 10 UG |
¥78,000 |
c-KIT Mutant (V559D), Active, Human | SCP | C06-12PG | 5 UG |
¥54,000 |
c-KIT Mutant (V559D), Active, Human | SCP | C06-12PG | 10 UG |
¥78,000 |
c-KIT Mutant (V654A), Active, Human | SCP | K06-13G | 5 UG |
¥54,000 |
c-KIT Mutant (V654A), Active, Human | SCP | K06-13G | 10 UG |
¥78,000 |
c-MER Mutant (A708S), Active, Human | SCP | M51-12BG | 5 UG |
¥54,000 |
c-MER Mutant (A708S), Active, Human | SCP | M51-12BG | 10 UG |
¥78,000 |
CSK, Active, Human | SCP | C63-10G | 5 UG |
¥54,000 |
CSK, Active, Human | SCP | C63-10G | 10 UG |
¥78,000 |
CSK, Active, Human | SCP | C63-10U | 5 UG |
¥54,000 |
CSK, Active, Human | SCP | C63-10U | 10 UG |
¥78,000 |
CSKtide | SCP | C63-58 | 1 MG |
¥20,000 |
FAK, Active, Human | SCP | P91-10G | 5 UG |
¥54,000 |
FAK, Active, Human | SCP | P91-10G | 10 UG |
¥78,000 |
FAK, Active, Human | SCP | P91-11H | 5 UG |
¥54,000 |
FAK, Active, Human | SCP | P91-11H | 10 UG |
¥78,000 |
FER, Active, Mouse | SCP | F16-11G | 5 UG |
¥54,000 |
FER, Active, Mouse | SCP | F16-11G | 10 UG |
¥78,000 |
FES, Active, Human | SCP | F03-10G | 5 UG |
¥54,000 |
FES, Active, Human | SCP | F03-10G | 10 UG |
¥78,000 |
FGR, Active, Human | SCP | F10-10G | 5 UG |
¥54,000 |
FGR, Active, Human | SCP | F10-10G | 10 UG |
¥78,000 |
FMS, Active, Human | SCP | C74-11G | 5 UG |
¥54,000 |
FMS, Active, Human | SCP | C74-11G | 10 UG |
¥78,000 |
FRK, Active, Human | SCP | F14-11G | 5 UG |
¥54,000 |
FRK, Active, Human | SCP | F14-11G | 10 UG |
¥78,000 |
FYN A, Active, Human | SCP | F15-10G | 5 UG |
¥54,000 |
FYN A, Active, Human | SCP | F15-10G | 10 UG |
¥78,000 |
FYN C, Unactive, Human | SCP | F15-14G | 20 UG |
¥52,000 |
FYN C, Unactive, Human | SCP | F15-14G | 50 UG |
¥104,000 |
HCK, Active, Human | SCP | H02-11G | 5 UG |
¥54,000 |
HCK, Active, Human | SCP | H02-11G | 10 UG |
¥78,000 |
HERC4, Human | SCP | H265-31G | 20 UG |
販売終了 |
HPK1, Active, Human | SCP | M23-11G | 5 UG |
¥54,000 |
HPK1, Active, Human | SCP | M23-11G | 10 UG |
¥78,000 |
HRAS1 (G12V) Protein, Human | SCP | R05-32H | 20 UG |
¥25,000 |
HRAS1 (G12V) Protein, Human | SCP | R05-32H | 50 UG |
¥38,000 |
HRAS1 (Mature form) Protein, Human | SCP | R05-31H | 20 UG |
販売終了 |
HRAS1 (Mature form) Protein, Human | SCP | R05-31H | 50 UG |
販売終了 |
ITK, Active, Human | SCP | I13-11G | 5 UG |
¥54,000 |
ITK, Active, Human | SCP | I13-11G | 10 UG |
¥78,000 |
JAK3, Active, Human | SCP | J03-11G | 5 UG |
¥54,000 |
JAK3, Active, Human | SCP | J03-11G | 10 UG |
¥78,000 |
LCK, Active, Human | SCP | L03-10G | 5 UG |
¥54,000 |
LCK, Active, Human | SCP | L03-10G | 10 UG |
¥78,000 |
LYN A, Active, Human | SCP | L13-18G | 5 UG |
¥54,000 |
LYN A, Active, Human | SCP | L13-18G | 10 UG |
¥78,000 |
LYN B, Active, Human | SCP | L13-10G | 5 UG |
¥54,000 |
LYN B, Active, Human | SCP | L13-10G | 10 UG |
¥78,000 |
PEAK1, Active, Human | SCP | P18-11G | 5 UG |
販売終了 |
PEAK1, Active, Human | SCP | P18-11G | 10 UG |
販売終了 |
PEAK1, Unactive, Human | SCP | P18-14G | 20 UG |
¥52,000 |
PEAK1, Unactive, Human | SCP | P18-14G | 50 UG |
¥104,000 |
PYK2, Active, Human | SCP | P92-11H | 5 UG |
¥54,000 |
PYK2, Active, Human | SCP | P92-11H | 10 UG |
¥78,000 |
Rous sarcoma virus SRC, Active, Virus | SCP | S19-10G | 5 UG |
¥54,000 |
Rous sarcoma virus SRC, Active, Virus | SCP | S19-10G | 10 UG |
¥78,000 |
SRC, Active, Human | SCP | S19-18G | 5 UG |
¥54,000 |
SRC, Active, Human | SCP | S19-18G | 10 UG |
¥78,000 |
SRMS, Active, Human | SCP | S20-11G | 5 UG |
¥54,000 |
SRMS, Active, Human | SCP | S20-11G | 10 UG |
¥78,000 |
STUB1 (CHIP), Human | SCP | C268-30H | 20 UG |
¥25,000 |
STUB1 (CHIP), Human | SCP | C268-30H | 50 UG |
¥38,000 |
STYK1 (NOK), Human | SCP | S53-35G | 20 UG |
¥52,000 |
STYK1 (NOK), Human | SCP | S53-35G | 50 UG |
¥104,000 |
SYK, Active, Human | SCP | S52-10G | 5 UG |
¥54,000 |
SYK, Active, Human | SCP | S52-10G | 10 UG |
¥78,000 |
τ-441 (1-391), Human | SCP | T08-55CN | 20 UG |
¥38,000 |
τ-441 (1-391), Human | SCP | T08-55CN | 50 UG |
¥81,000 |
τ-441 (1-421), Human | SCP | T08-55BN | 20 UG |
¥38,000 |
τ-441 (1-421), Human | SCP | T08-55BN | 50 UG |
¥81,000 |
τ-441 (G272V), Human | SCP | T08-56DN | 20 UG |
¥38,000 |
τ-441 (G272V), Human | SCP | T08-56DN | 50 UG |
¥81,000 |
τ-441 (K257T), Human | SCP | T08-56N | 20 UG |
¥38,000 |
τ-441 (K257T), Human | SCP | T08-56N | 50 UG |
¥81,000 |
τ-441 (N279K), Human | SCP | T08-56EN | 20 UG |
¥38,000 |
τ-441 (N279K), Human | SCP | T08-56EN | 50 UG |
¥81,000 |
TTK, Active, Human | SCP | T20-10G | 5 UG |
¥54,000 |
TTK, Active, Human | SCP | T20-10G | 10 UG |
¥78,000 |
TXK, Active, Human | SCP | T19-11G | 5 UG |
¥54,000 |
TXK, Active, Human | SCP | T19-11G | 10 UG |
¥78,000 |
TYK2 (JTK1), Active, Human | SCP | T21-11G | 5 UG |
¥54,000 |
TYK2 (JTK1), Active, Human | SCP | T21-11G | 10 UG |
¥78,000 |
UBA2 (SAE2), Human | SCP | U202-30G | 20 UG |
¥52,000 |
UBA2 (SAE2), Human | SCP | U202-30G | 50 UG |
¥104,000 |
UBA3 (UBE1C), Human | SCP | U203-30G | 20 UG |
¥52,000 |
UBA3 (UBE1C), Human | SCP | U203-30G | 50 UG |
¥104,000 |
UBE2A, Human | SCP | U210-30H | 20 UG |
販売終了 |
UBE2A, Human | SCP | U210-30H | 50 UG |
販売終了 |
UBE2B, Human | SCP | U211-30H | 20 UG |
¥25,000 |
UBE2B, Human | SCP | U211-30H | 50 UG |
¥38,000 |
UBE2C, Human | SCP | U212-30H | 20 UG |
販売終了 |
UBE2C, Human | SCP | U212-30H | 50 UG |
販売終了 |
UBE2D1 (UBCH5A), Human | SCP | U213-30H | 20 UG |
販売終了 |
UBE2D1 (UBCH5A), Human | SCP | U213-30H | 50 UG |
販売終了 |
UBE2D2 (UBC4), Xenopus | SCP | U214-30H | 20 UG |
販売終了 |
UBE2D2 (UBC4), Xenopus | SCP | U214-30H | 50 UG |
販売終了 |
UBE2D3 (UBCH5C), Human | SCP | U215-30H | 20 UG |
販売終了 |
UBE2D3 (UBCH5C), Human | SCP | U215-30H | 50 UG |
販売終了 |
UBE2E3 (UBCH9), Human | SCP | U219-30H | 20 UG |
販売終了 |
UBE2E3 (UBCH9), Human | SCP | U219-30H | 50 UG |
販売終了 |
UBE2F, Human | SCP | U220-30H | 20 UG |
¥25,000 |
UBE2F, Human | SCP | U220-30H | 50 UG |
¥38,000 |
UBE2G1 (UBC7), Human | SCP | U221-30H | 20 UG |
販売終了 |
UBE2G1 (UBC7), Human | SCP | U221-30H | 50 UG |
販売終了 |
UBE2H, Human | SCP | U223-30H | 20 UG |
¥25,000 |
UBE2H, Human | SCP | U223-30H | 50 UG |
¥38,000 |
UBE2I, Human | SCP | U224-30H | 20 UG |
販売終了 |
UBE2I, Human | SCP | U224-30H | 50 UG |
販売終了 |
UBE2J1, Human | SCP | U225-30G | 20 UG |
¥52,000 |
UBE2J1, Human | SCP | U225-30G | 50 UG |
¥104,000 |
UBE2K (UBC1), Human | SCP | U227-30H | 20 UG |
販売終了 |
UBE2K (UBC1), Human | SCP | U227-30H | 50 UG |
販売終了 |
UBE2L6 (UBCH8), Human | SCP | U229-30H | 20 UG |
販売終了 |
UBE2L6 (UBCH8), Human | SCP | U229-30H | 50 UG |
販売終了 |
UBE2N (UBC13), Human | SCP | U231-30H | 20 UG |
販売終了 |
UBE2N (UBC13), Human | SCP | U231-30H | 50 UG |
販売終了 |
UBE2O, Human | SCP | U232-30G | 20 UG |
販売終了 |
UBE2O, Human | SCP | U232-30G | 50 UG |
販売終了 |
UBE2R2 (UBC3B), Human | SCP | U235-30H | 20 UG |
¥25,000 |
UBE2R2 (UBC3B), Human | SCP | U235-30H | 50 UG |
¥38,000 |
UBE2U, Human | SCP | U237-30G | 20 UG |
¥52,000 |
UBE2U, Human | SCP | U237-30G | 50 UG |
¥104,000 |
UBE2V2, Human | SCP | U239-30H | 20 UG |
¥25,000 |
UBE2V2, Human | SCP | U239-30H | 50 UG |
¥38,000 |
UBE2W (UBC16), Human | SCP | U240-30G | 20 UG |
¥25,000 |
UBE2W (UBC16), Human | SCP | U240-30G | 50 UG |
¥38,000 |
UBE2Z (USE1), Human | SCP | U241-31H | 20 UG |
¥25,000 |
UBE2Z (USE1), Human | SCP | U241-31H | 50 UG |
¥38,000 |
UBLE1A (SAE1), Human | SCP | U208-30G | 20 UG |
¥52,000 |
UBLE1A (SAE1), Human | SCP | U208-30G | 50 UG |
¥104,000 |
VLK, Human | SCP | V05-31G | 20 UG |
¥52,000 |
VLK, Human | SCP | V05-31G | 50 UG |
¥104,000 |
WEE1, Human | SCP | W01-35G | 20 UG |
販売終了 |
WEE1, Human | SCP | W01-35G | 50 UG |
販売終了 |
YES1, Active, Human | SCP | Y01-10G | 5 UG |
¥54,000 |
YES1, Active, Human | SCP | Y01-10G | 10 UG |
¥78,000 |
ZAP70, Active, Human | SCP | Z02-10G | 5 UG |
¥54,000 |
ZAP70, Active, Human | SCP | Z02-10G | 10 UG |
¥78,000 |
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用としては使用しないように、十分ご注意ください。
※ 表示価格について
- 「高精製度キナーゼ - Cytoplasmic Tyrosine Kinases」は、下記のカテゴリーに属しています。
-
- カテゴリから探す > シグナル伝達 > リン酸化/ユビキチン化/SUMO化 > プロテインキナーゼ
- 研究分野から探す > がん研究 > リン酸化の検出・測定 > リコンビナントキナーゼ