Anti APP - Cosmo Bio Co.,Ltd.



Anti APP Antibody

Alzheimer amyloid precursor protein

Catalog No.: BAM-74-104-EX
Size: 100UL
Price: ¥34500
antigen/source: APP
host: Rabbit
Description: [Immunogen]C-terminal, a.a. 671-695
Purity: Serum
Application: Western Blot
Enzyme Linked Immunosorbent Assay
catalog info: Catalog 2012-p8
Storage: -20C
Immunogen: Human
Clone: AC1
Reacts with: Human


Fig.1 Endogenous expression of APP in mouse P19 cells during neural differentiation was analysed by Western blotting using this antibody (ref.2). lane1, undifferentiated P19 cells (U); lane2, day 3; lane3, day4; lane4, day7; lane5, day12; lane6, day15; lane7, day17. APP species with 105-120K markedly increased during days 3-12, but declined thereafter. On the other hand, APP species with 115-130K were detected on day 15 and 17.


Fig.2 Immunocytochemistry for APP (ref 4). Mouse dorsal root ganglion neurons were cultured in the presence of nerve growth factor (NGF), fixed at indicated time points, and immunostained for the C-terminus of APP with this antibody. Left panels are differential interference contrast images of the same fields. APP immunoreactivity was very low at 0 h but increased in neuronal somata (arrows), neurites (arrowheads) 3-12 h after NGF treatment, a period when neurites showed a marked outgrowth. APP immunoreactivity decreased at 36 h.