Michael C. Mullenix, Ph. D.
演者VP of Research and Development, Ann Arbor

Protein homeostasis or 'proteostasis' is the process that regulates proteins within the cell in order to maintain the health of both the cellular proteome and the organism itself. Proteostasis involves a highly complex interconnection of pathways that influence the fate of a protein from synthesis to degradation. As individual components are affected, the others adjust accordingly to maintain normal function. Disruption of one or more of these proteostasis influencers can manifest in pathologies such as Alzheimer's disease, cancer, and diabetes. Loss of proteostasis can lead to abnormal cell states such as unchecked growth (cancer), triggering of cell death pathways and production of improperly folded or non-functional proteins. Enzo provides quantitative experimental techniques to measure disruption of proteostasis as indicated by physical and physiological changes in cells, tissues and other biological samples. The presentation will provide an overview of methodologies within the areas of protein synthesis, modification, and degradation. A focus will be made on ubiquitin/proteasome and heat shock protein research reagents. In addition, an overview of autophagy as an emerging pathway of interest in cellular regulation of protein turnover, will be provided. The overview will include how autophagy's relationship to disease can be quantified and characterized by our first-to-market immunoassays, cell based assays, and compound libraries.

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