商品情報

ハイスループットスクリーニングを成功させるためにはターゲットとなるキナーゼが重要な因子となりますが、シグナルケム社の高精製度キナーゼはバキュロウイルス発現系で作製(一部例外あり)したリコンビナントタンパク質で、変異活性を抑制しているため、信頼性の高い結果を得ることができます。(→ 活性型キナーゼ/基質/抗体対応表

非常に精製度の高い、活性のあるシグナル伝達タンパク質
を製造する専門企業からご提供!

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  • 【キナーゼプロファイリングサービス】もあります!
    約 450 種類のキナーゼによる酵素活性ベースの阻害剤の探索・解析に 最適なプロファイリングサービス
 

背景

キナーゼとは?

リン酸化は、タンパク質及び脂質の翻訳後修飾(PTM;post translational modification)の主要なステップで、細胞内のタンパク質及び脂質の機能を調節する最も効果的な方法の1つです。プロテインキナーゼは、最も大きな酵素クラスの1つ(516ファミリーメンバーが存在し、ヒトの全ての遺伝子の2%を占めています)で、ATPのγリン酸の、タンパク質中のアミノ酸(セリン、スレオニン、チロシンなど)のヒドロキシル基又は脂質中のグリコシル基への転移を触媒します。

プロテインキナーゼは、ヒトだけでなく、バクテリアや植物にも存在しています。ヒトの全てのタンパク質のうち最大で30%が、プロテインキナーゼ活性によるリン酸化を受けている可能性があります。リン酸化は、通常、基質の機能的変化を引き起こし、酵素活性、細胞内局在、他のタンパク質との関係性などを変化させます。

プロテインキナーゼは、細胞内の多様なシグナル経路に関与する、高度に調節されたタンパク質です。成長因子、サイトカイン、ホルモン類などは、様々なプロテインキナーゼターゲットの活性をオン又はオフに切り替え、それによりさらにその下流の基質タンパク質を調節します。

プロテインキナーゼによるシグナルの欠陥は、多くのヒトの疾患の原因となり、これらのターゲットは、治療介入のために積極的に追及されています。小分子の阻害剤や中和抗体を用いたプロテインキナーゼのターゲッティングは、癌などの様々なヒトの疾患の治療に非常に有益です。プロテインキナーゼをターゲットとするいくつかの薬剤が既に承認され、さらに多くの候補薬が臨床試験中です。

特長

  • 高純度(>90〜95%)
    融合タンパク質(His、GSTタグ)
    効率的な精製 
  • 高特異性
    高いS/N比で優れた結果を実現!
    厳密なQCにより特異活性を測定 

活性型キナーゼ/基質/抗体対応表

A B C D E F G H I J K L M N O P Q R S T U V W X YZ

 

A

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
ABL1 (E255K), Active A03-12BG Abltide A02-58        
ABL1 (G250E), Active A03-12CG Abltide A02-58        
ABL1 (T315I), Active A03-12DG Abltide A02-58        
ABL1 (Y253F), Active A03-12EG Abltide A02-58        
ABL1, Active A03-11H Abltide A02-58        
ABL1, Active A03-18H Abltide A02-58        
ABL2, Active A04-11H Abltide A02-58        
ACK, Active A05-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
AKT1, Active A16-10G Akt (SGK) Substrate A08-58       Anti-AKT (pan) A16-63R
Anti-AKT (pan) A16-63BR
Anti-AKT2/3 A17-63BR
AKT2, Active A17-10G Akt (SGK) Substrate A08-58         Anti-AKT (pan) A16-63R
Anti-AKT (pan) A16-63BR
Anti-AKT2/3 A17-63BR
AKT2, Active   A17-10H Akt (SGK) Substrate A08-58     Anti-AKT (pan) A16-63R
Anti-AKT (pan) A16-63BR
Anti-AKT2/3 A17-63BR
AKT3, Active A18-10G Akt (SGK) Substrate A08-58     Anti-AKT (pan) A16-63R
Anti-AKT (pan) A16-63BR
Anti-AKT2/3 A17-63BR
ALK1, Active A09-11G     Casein, Dephosphorylated C03-54BN    
ALK2, Active A06-11G     Casein, Dephosphorylated C03-54BN    
ALK2 (R206H), Active A06-12BG     Casein Protein C03-54N    
ALK3 (BMPR1A), Active B04-11G TGFBR1 Peptide T36-58        
ALK4, Active A07-11G     Casein, Dephosphorylated C03-54BN    
ALK6 (BMPR1B), Active B05-11G TGFBR1 Peptide T36-58        
AMPK (A1/B1/G1), Active P47-10H SAMStide S07-58       Anti-AMPK alpha 1 P47-63R
Anti-AMPK alpha 1/2 P47-63BR
AMPK (A1/B1/G2), Active P55-10H SAMStide S07-58       Anti-AMPK alpha 1 P47-63R
Anti-AMPK alpha 1/2 P47-63BR
AMPK (A1/B1/G3), Active P56-10H SAMStide S07-58       Anti-AMPK alpha 1 P47-63R
Anti-AMPK alpha 1/2 P47-63BR
AMPK (A1/B2/G1), Active P50-10H SAMStide S07-58       Anti-AMPK alpha 1 P47-63R
Anti-AMPK alpha 1/2 P47-63BR
AMPK (A2/B1/G1), Active P48-10H SAMStide S07-58     Anti-AMPK alpha 1/2 P47-63BR
AMPK (A2/B2/G1), Active P49-10H SAMStide S07-58     Anti-AMPK alpha 1/2 P47-63BR
AMPK (A2/B2/G2), Active P54-10H SAMStide S07-58     Anti-AMPK alpha 1/2 P47-63BR
ASK1, Active  M13-11G       MBP Protein  M42-54G Anti-ASK1 M13-60M
Anti-ASK1 M13-60BM
AURORA A, Active A28-10G     MBP Protein M42-51N    
AURORA A, Active A28-18G     MBP Protein M42-51N    
AURORA B, Active A31-10G     MBP Protein M42-54G    
AURORA C, Active A33-10G     MBP Protein M42-54G    
AXL, Active A34-11H Axltide A16-58        
AXL (R499C), Active A34-12BG Axltide A16-58        
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B

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
BLK, Active B02-10G Poly (4:1 Glu, Tyr) Peptide P61-58        
BMPR2, Active B06-11H     MBP Protein M42-51N    
BMX, Active B07-10G Poly (4:1 Glu, Tyr) Peptide P61-58        
BRAF (V599E), Active B08-13G     MEK1, Unactive M02-14BG    
BRAF, Active B08-11G     MEK1, Unactive M02-14BG    
BRK, Active P94-10G Poly (4:1 Glu, Tyr) Peptide P61-58        
BRSK1, Active B13-10G CHKtide C10-58        
BRSK2, Active B14-10G CHKtide C10-58        
BTK, Active B10-10H Poly (4:1 Glu, Tyr) Peptide P61-58        
BUB1B, Active B12-11G RS Repeat Peptide R55-58        
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C

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
c-KIT, Active K06-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
c-KIT (D820E), Active C06-12BG Poly (4:1 Glu, Tyr) Peptide P61-58        
c-KIT (N822K), Active C06-12DG Poly (4:1 Glu, Tyr) Peptide P61-58        
c-KIT (T670E), Active C06-12EG Poly (4:1 Glu, Tyr) Peptide P61-58        
c-KIT (T670I), Active C06-12FG Poly (4:1 Glu, Tyr) Peptide P61-58        
c-KIT (V654A), Active K06-13G Poly (4:1 Glu, Tyr) Peptide P61-58        
c-KIT (Y823D), Active C06-12GG Poly (4:1 Glu, Tyr) Peptide P61-58        
c-MER, Active M51-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
c-MER (A708S), Active M51-12BG Poly (4:1 Glu, Tyr) Peptide P61-58        
CAMK1, Active C07-10G Autocamtide-2 A15-58     Anti-CAMK C07-60M
CAMK1 beta, Active C08-10G Autocamtide-2 A15-58        
CAMK1 delta, Active C09-10G Autocamtide-2 A15-58        
CAMK1 gamma, Active C10-10BG Autocamtide-2 A15-58        
CAMK1 gamma, Active C10-11G Autocamtide-2 A15-58        
CAMK2 alpha, Active C11-10G Autocamtide-2 A15-58        
CAMK2 beta, Active C12-10H Autocamtide-2 A15-58        
CAMK2 delta, Active C13-10G Autocamtide-2 A15-58        
CAMK2 gamma, Active C14-10G Autocamtide-2 A15-58        
CAMK4, Active C15-10G Autocamtide-2 A15-58        
CAMKK1, Active C17-10G     MBP Protein M42-54G    
CAMKK2, Active C18-10G     MBP Protein M42-51N    
CASK, Active C19-11G PKA Substrate C01-58        
CDC7/DBF4, Active C26-10G PDKtide P10-58        
CDK1/CyclinA1, Active C22-18BG     Histone H1 Protein H10-54N    
CDK1/CyclinA2, Active C22-18G     Histone H1 Protein H10-54N    
CDK1/CyclinB1, Active C22-10G     Histone H1 Protein H10-54N    
CDK2/CyclinA1, Active C29-10BG     Histone H1 Protein H10-54N    
CDK2/CyclinA2, Active C29-10G     Histone H1 Protein H10-54N    
CDK2/CyclinE1, Active C29-18G     Histone H1 Protein H10-54N    
CDK3/CyclinE1, Active C30-10G     Histone H1 Protein H10-54N    
CDK4/CyclinD1, Active C31-10G     Rb Protein R05-55G    
CDK4/CyclinD3, Active C31-18G     Rb Protein R05-55G    
CDK5/p25, Active C33-10G     Histone H1 Protein H10-54N    
CDK5/p35, Active C33-10BG     Histone H1 Protein H10-54N    
CDK6/CyclinD1, Active C35-18H     Rb Protein R05-55G    
CDK6/CyclinD3, Active C35-10H     Rb Protein R05-55G    
CDK7/CyclinH1/MNAT1, Active C36-10H     MBP Protein M42-51N    
CDK9/CyclinK, Active C40-10G PDKtide P10-58        
CHK1, Active C47-10G CHKtide C10-58        
CHK1, Active C47-10H CHKtide C10-58        
CHK2, Active C48-10G CHKtide C10-58     Anti-CHK2 C48-60M
CK1 alpha 1, Active C64-10G     Casein, Dephosphorylated C03-54BN    
CK1 delta, Active C65-10G     Casein, Dephosphorylated C03-54BN    
CK1 epsilon, Active C66-10G     Casein, Dephosphorylated C03-54BN    
CK1 gamma 1, Active C68-11G     Casein Protein C03-54N    
CK1 gamma 2, Active C68-10BG     Casein, Dephosphorylated C03-54BN    
CK1 gamma 3, Active C68-10CG     Casein, Dephosphorylated C03-54BN    
CK2 alpha 1, Active C70-10G     Casein Protein C03-54N    
CK2 alpha 2, Active C71-10G CK2 Substrate C08-58        
CLK1, Active C57-11G     MBP Protein M42-54G    
CLK2, Active C58-11G S6K Substrate S05-58        
CLK3, Active C60-10G     MBP Protein M42-51N    
COT, Active   M16-11G         MEK1, Unactive M02-14BG        
ERK1, Unactive M29-14U
MBP Protein M42-54G
CSK, Active C63-10G Poly (4:1 Glu, Tyr) Peptide P61-58        
CSK, Active C63-10U Poly (4:1 Glu, Tyr) Peptide P61-58        
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D

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
DAPK1, Active D01-11G     MBP Protein M42-51N    
DAPK2, Active D02-10G     LC20 Protein M89-54G    
DAPK3, Active D03-10G     MBP Protein M42-51N    
DCAMKL1, Active D14-10G Autocamtide-2 A15-58        
DCAMKL2, Active D15-11G HSP27tide H31-58        
DDR1, Active D05-11G Axltide A16-58        
DDR2, Active D06-11BG Axltide A16-58        
DMPK, Active D07-10G Axltide A16-58        
DRAK2 (STK17B), Active S34-10G MRCL3 Peptide M56-58        
DYRK2, Active D10-10G DYRKtide D96-58        
DYRK3, Active D11-11G DYRKtide D96-58        
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E

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
EEF2K, Active E01-10G EF2tide E01-58        
EGFR, Active E10-11G Poly (4:1 Glu, Tyr) Peptide P61-58       Anti-EGFR E10-63BR
Anti-EGFR E10-63R
EGFR (L858R), Active E10-12BG Poly (4:1 Glu, Tyr) Peptide P61-58        
EGFR (L861Q), Active E10-12CG Poly (4:1 Glu, Tyr) Peptide P61-58        
EGFR (T790M L858R), Active E10-12DG Poly (4:1 Glu, Tyr) Peptide P61-58        
EGFR (T790M), Active E10-12EG Poly (4:1 Glu, Tyr) Peptide P61-58        
EIF2AK1 (HRI), Active H07-10G RS Repeat Peptide R55-58        
EIF2AK2, Active P80-11G     MBP Protein M42-51N Anti-EIF2AK2 P80-63R
EIF2AK3, Active E11-11G     SMAD3 Protein S12-30G    
EIF2AK4 (GCN2), Active E12-11G RS Repeat Peptide R55-58        
EPHA1, Active E13-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
EPHA1, Active E13-18G Poly (4:1 Glu, Tyr) Peptide P61-58        
EPHA2, Active E14-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
EPHA3, Active E15-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
EPHA4, Active E16-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
EPHA6, Active E18-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
EPHA7, Active E19-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
EPHB1, Active E21-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
EPHB2, Active E22-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
EPHB3, Active E23-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
EPHB4, Active E24-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
EPHB4, Active E24-11H Poly (4:1 Glu, Tyr) Peptide P61-58        
ERK1, Active M29-10U     MBP Protein M42-51N Anti-ERK1 M29-60BM
Anti-ERK1 M29-60M
Anti-ERK1 M29-60CM
Anti-ERK1/2 M29-60EM
ERK1, Active M29-10G     MBP Protein M42-51N Anti-ERK1 M29-60BM
Anti-ERK1 M29-60M
Anti-ERK1 M29-60CM
Anti-ERK1/2 M29-60EM
ERK2, Active M28-10G     MBP Protein M42-51N Anti-ERK1/2 M29-60EM
Anti-ERK2 M28-63R
ERK5, Active M32-10G     MBP Protein M42-51N    
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F

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
FAK, Active P91-11H Poly (4:1 Glu, Tyr) Peptide P61-58        
FAK, Active P91-10G Poly (4:1 Glu, Tyr) Peptide P61-58        
FASTK, Active F01-10G PKA Substrate C01-58        
FER, Active F16-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
FES, Active F03-10G Poly (4:1 Glu, Tyr) Peptide P61-58        
FGFR1 (FLT2), Active F04-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
FGFR1 (V561M), Active F04-13G Poly (4:1 Glu, Tyr) Peptide P61-58        
FGFR2, Active F05-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
FGFR3, Active F06-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
FGFR4, Active F07-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
FGR, Active F10-10G Poly (4:1 Glu, Tyr) Peptide P61-58        
FLT1, Active F11-11G IGF1Rtide I15-58        
FLT3, Active F12-11G     MBP Protein M42-51N    
FLT3 (D835Y), Active F12-12BG Abltide A02-58        
FLT4, Active F13-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
FMS, Active C74-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
FRK, Active F14-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
FYN A, Active F15-10G Poly (4:1 Glu, Tyr) Peptide P61-58        
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G

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
GCK, Active M24-10G     MBP Protein M42-51N    
GLK, Active M25-11G Abltide A02-58        
GRK1, Active R03-10G Modified PLKtide P41-58B        
GRK2, Active A14-10G PLKtide P41-58        
GRK3, Active A15-11G GRKtide G46-58        
GRK5, Active G03-10G     Casein Protein C03-54N    
GRK6, Active G04-10G PLKtide P41-58        
GRK7, Active G05-10G PLKtide P41-58        
GSK3 alpha, Active  G08-10G GSK3 Substrate  G50-58       Anti-GSK3 alpha/beta G09-63R
Anti-GSK3 alpha G08-63R
GSK3 beta, Active  G09-10G GSK3 Substrate  G50-58       Anti-GSK3 alpha/beta G09-63R
Anti-GSK3 beta G09-60M
GSK3 beta, Active  G09-10H GSK3 Substrate  G50-58       Anti-GSK3 alpha/beta G09-63R
Anti-GSK3 beta G09-60M
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H

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
Haspin (GSG2), Active G10-11G     Histone H3 Protein H12-54N    
HCK, Active H02-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
HER2, Active E27-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
HER4, Active E29-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
HGK, Active M26-11G     MBP Protein M42-51N    
HIPK1, Active H03-11G     MBP Protein M42-51N    
HIPK2, Active H04-11G     MBP Protein M42-51N    
HIPK3, Active H05-13H     MBP Protein M42-51N    
HIPK4, Active H06-10G     MBP Protein M42-51N    
HPK1, Active M23-11G     MBP Protein M42-51N    
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I

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
ICK, Active I01-10G     MBP Protein M42-51N    
IGF1R, Active I02-11H IGF1Rtide I15-58        
IKK alpha, Active C51-10G IKKtide I33-58        
IKK beta, Active I03-10BG IKKtide I33-58        
InsR, Active I08-11G Axltide A16-58        
IRAK2, Active I10-10BG Modified AKT Substrate A05-58B        
IRAK4, Active I12-10G     MBP Protein M42-54G    
IRR, Active I07-11G Axltide A16-58        
ITK, Active I13-11G     MBP Protein M42-51N    
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J

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
JAK3, Active J03-11G Poly (4:1 Glu, Tyr) Peptid P61-58        
JNK1, Active M33-10G     ATF2 Protein A10-55G Anti-JNK1 M33-63R
JNK2, Active M34-10BG p38 Substrate P03-58     Anti-JNK2 M34-60M
Anti-JNK2/3 M34-63R
JNK3, Active M35-10BG p38 Substrate P03-58     Anti-JNK2/3 M34-63R
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K

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
KDR, Active K01-11G     MBP Protein M42-51N    
KHS1, Active M27-10G Poly (4:1 Glu, Tyr) Peptide P61-58        
KSR1, Active K07-11G Modified PKA Substrate C01-58B        
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L

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
LATS1, Active L01-11G SGKtide S08-58        
LATS2, Active L02-11G SGKtide S08-58        
LCK, Active L03-10G Poly (4:1 Glu, Tyr) Peptide P61-58        
LOK, Active S29-11G Axltide A16-58        
LRRK2, Active L10-11G LRRKtide L10-58        
LYN A, Active L13-18G Poly (4:1 Glu, Tyr) Peptide P61-58        
LYN B, Active L13-10G SRC Substrate S30-58        
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M

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
MAPKAPK2, Active M40-11G HSP27tide H31-58     Anti-MAPKAPK2/3 M40-63R
MAPKAPK2, Active M40-11H HSP27tide H31-58     Anti-MAPKAPK2/3 M40-63R
MAPKAPK3, Active M41-10G HSP27tide H31-58     Anti-MAPKAPK2/3 M40-63R
MAPKAPK5, Active M42-10G HSP27tide H31-58        
MARK1, Active M43-10G CHKtide C10-58        
MARK2, Active M44-10G CHKtide C10-58        
MARK3, Active M45-10G CHKtide C10-58        
MARK4, Active M46-10G CHKtide C10-58        
MEK1, Active M02-10G     ERK1, Unactive M29-14U Anti-MEK1 M02-60M
MBP Protein M42-51N Anti-MEK1/2 M02-63R
MEK1 (EE), Active M02-12G     ERK1, Unactive M29-14U Anti-MEK1 M02-60M
MBP Protein M42-51N Anti-MEK1/2 M02-63R
MEK2, Active M03-10G     ERK2, Unactive M28-14G Anti-MEK1/2 M02-63R
MBP Protein M42-51N Anti-MEK2 M03-63R
MEKK1, Active M09-11G     MEK1, Unactive M02-14BG    
ERK1, Unactive M29-14G
MBP Protein M42-51N
MEKK2, Active M10-10G     MEK1, Unactive M02-14BG    
ERK1, Unactive M29-14U
MBP Protein M42-51N
MEKK3, Active M11-10G     MBP Protein M42-54G    
MEKK6, Active M14-11G     MBP Protein M42-51N    
MELK, Active M50-11G ZIPtide Z16-58        
MET, Active M52-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
MET, Active M52-18G Poly (4:1 Glu, Tyr) Peptide P61-58        
MET(M1250T), Active M52-12BG Poly (4:1 Glu, Tyr) Peptide P61-58        
MINK1, Active M53-11G     MBP Protein M42-54G    
MLCK, Active M62-11G     LC20 Protein M89-54G    
MLK1, Active M17-11G     MBP Protein M42-51N    
MLK2, Active M18-11G     MBP Protein M42-51N    
MLK3, Active M19-11G     MBP Protein M42-51N    
MNK1, Active M54-10G Modified EIF2S Peptide E23-58B        
MNK2, Active M55-10G     MBP Protein M42-54G    
MRCK alpha, Active C27-11G S6K Substrate S05-58        
MRCK beta, Active C28-11G S6K Substrate S05-58        
MSK1, Active R19-10G RSK Substrate S06-58        
MSK2, Active R18-10G RSK Substrate S06-58        
MSSK1, Active S41-10G PKCtide P15-58        
MST1, Active S25-10G Axltide A16-58        
MST3, Active S42-11G PKCtide P15-58        
MST4, Active M59-10G     MBP Protein M42-54G    
MUSK, Active M60-11G     MBP Protein M42-51N    
MYLK2, Active M63-10H     LC20 Protein M89-54G    
MYLK3, Active M64-10G     LC20 Protein M89-54G    
MYO3 beta, Active M66-11G     MBP Protein M42-54G    
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N

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
NDR, Active S49-10G Modified PKA Substrate C01-58B        
NDR2, Active S50-10G Modified SGKtide S08-58B        
NEK1, Active N02-11G     MBP Protein M42-51N    
NEK2, Active N03-10G     MBP Protein M42-54G    
NEK3, Active N05-10G     MBP Protein M42-51N    
NEK5, Active N07-11G     MBP Protein M42-51N    
NEK6, Active N08-10G     MBP Protein M42-54G    
NEK7, Active N09-10G     Casein Protein C03-54N    
NEK9, Active N11-11G     MBP Protein M42-51N    
NEK11, Active N13-10G     MBP Protein M42-51N    
NIK, Active M22-11G     MBP Protein M42-51N    
NLK, Active N15-10G     MBP Protein M42-51N    
NUAK1, Active N19-10G CHKtide C10-58        
NUAK2, Active N20-10G CHKtide C10-58      
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P

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
p38 alpha, Active  M39-10BG  p38 Substrate  P03-58        Anti-p38 alpha M39-60M
Anti-p38 alpha M39-63R
p38 beta, Active M36-10BG p38 Substrate P03-58     Anti-p38 beta M36-63R
p38 delta, Active M38-10BG p38 Substrate P03-58        
p38 gamma, Active M37-10BG p38 Substrate P03-58     Anti-p38 gamma M37-63R
p70S6K, Active R21-10H S6K Substrate S05-58     Anti-p70S6K R21-63R
p70S6Kb, Active R22-10G RSK Substrate S06-58     Anti-p70S6K R21-63R
PAK1, Active P02-10BG PAKtide P08-58     Anti-PAK1 P02-63R
PAK1/CDC42, Active P02-10G PAKtide P08-58     Anti-PAK1 P02-63R
PAK3, Active P04-10G     MBP Protein M42-54G    
PAK4, Active P05-10BG Modified AKT Substrate II A05-58C        
PAK6, Active P06-10G PAKtide P08-58        
PAK7, Active P07-10G Akt(PKB) Substrate A05-58        
PASK, Active P08-11G ZIPtide Z16-58        
PDGFR alpha, Active P12-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
PDGFR alpha, Active P12-18G Poly (4:1 Glu, Tyr) Peptide P61-58        
PDGFR alpha(D842V), Active P12-12BG     MBP Protein M42-51N    
PDGFR alpha(T674I), Active P12-12CG     MBP Protein M42-51N    
PDGFR beta, Active P13-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
PDHK1, Active P57-10G     PDHA1 Protein P57-55H    
PDHK2, Active P58-10G     PDHA1 Protein P57-55H    
PDHK3, Active P59-10G     PDHA1 Protein P57-55H    
PDHK4, Active P60-10G     PDHA1 Protein P57-55H    
PDK1, Active P14-10H PDKtide P10-58        
PEAK1, Active P18-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
PHKG1, Active P19-10G ZIPtide Z16-58        
PHKG2, Active P20-10G ZIPtide Z16-58        
PI3K (p110 alpha (E545K) /p85 alpha), Active P27-15H PI(4,5)P2 [lipid substrate]          
PI3K (p110 alpha/p55 gamma), Active P27-10CH PI(4,5)P2 [lipid substrate]          
PI3K (p110 alpha/p85 alpha), Active P27-18H PI(4,5)P2 [lipid substrate]          
PI3K (p110 alpha/p85 alpha), Active P27-10H PI(4,5)P2 [lipid substrate]          
PI3K (p110 beta/p85 alpha), Active P28-10H PI(4,5)P2 [lipid substrate]          
PI3K (p110 beta/p85 beta), Active P28-10BH PI(4)P [lipid substrate]          
PI3K (p110 delta/p85 alpha), Active P30-10H PI/PS [lipid substrate]          
PI3K (p120 gamma), Active P29-10H PI/PS [lipid substrate]          
PI4K2A, Active P21-10G PI [lipid substrate]          
PI4K2B, Active P22-10G PI [lipid substrate]          
PI4KB, Active P32-10G PI [lipid substrate]          
PIK3C2A, Active P23-11G PI [ipid substrate]          
PIK3C2G, Active P25-11G PI [lipid substrate]          
PIK3C3 (Vps34), Active P26-10G PI [lipid substrate]          
PIM1, Active P35-10G S6K Substrate S05-58        
PIM2, Active P36-10G S6K Substrate S05-58        
PIM3, Active P37-10G RSK Substrate S06-58        
PIP4K2A, Active P76-10AG PI(5)P [lipid substrate]          
PIP4K2C, Active P76-10CG PI(3)P [lipid substrate]          
PIP5K1A, Active P16-10AG PI(3,4)P2 [lipid substrate]          
PIP5K1B, Active P16-10BG PI(3,4)P2 [lipid substrate]          
PIP5K1C, Active P16-10CG PI(3,4)P2 [lipid substrate]          
PKAc beta, Active P52-10G CREBtide C50-58        
PKAca, Active P51-10G CREBtide C50-58     Anti-PKAc P51-63R
PKAc gamma, Active P53-10G CREBtide C50-58        
PKC alpha, Active P61-10G CREBtide C50-58        
PKC alpha, Active P61-18G CREBtide C50-58        
PKC beta I, Active P62-10G PKCtide P15-58        
PKC beta II, Active P63-10G CREBtide C50-58        
PKC delta, Active   P64-10G CREBtide   C50-58     Anti-PKC delta P64-63R
Anti-PKC delta P64-63CR
Anti-PKC delta/ theta P64-63DR
PKC epsilon, Active P65-10G PKCtide P15-58        
PKC eta, Active P67-10G PKCtide P15-58        
PKC gamma, Active P66-10G PKCtide P15-58        
PKC iota, Active P68-10G CREBtide C50-58        
PKC mu, Active P72-10G CREBtide C50-58     Anti-PKC mu P72-63R
PKC nu, Active P73-10G CREBtide C50-58        
PKC theta, Active P74-10G  PKCtide P15-58       Anti-PKC theta P74-63R
Anti-PKC delta/theta P64-63DR
PKC zeta, Active P75-10G CREBtide C50-58     Anti-PKC zeta P75-63R
PKD2, Active P76-10G CREBtide C50-58        
PKD2 (G870E), Active P76-12CG CREBtide C50-58        
PKN2/PRK2, Active P71-10G CREBtide C50-58        
PKN3/PRK3, Active P69-10G RSK Substrate S06-58        
PLK1, Active P41-10H     Casein, Dephosphorylated C03-54BN    
PLK2, Active P42-10G     Casein, Dephosphorylated C03-54BN    
PLK3, Active P43-13G     Casein, Dephosphorylated C03-54BN    
PLK4, Active P44-11G     MBP Protein M42-51N    
PRKG1, Active P78-10BG RSK Substrate S06-58        
PRKG2, Active P79-10G RSK Substrate S06-58        
PRKX, Active P81-10G PAKtide P08-58        
PYK2, Active P92-11H Poly (4:1 Glu, Tyr) Peptide P61-58     Anti-PYK2 P92-63R
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Q

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
QIK, Active S15-10G AMARA Peptide A11-58        
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R

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
RAF1 (EE), Active R01-13G     MEK1, Unactive M02-14BG    
ERK1, Unactive M29-14G
MBP Protein M42-54G
RET, Active R02-11G IGF1Rtide I15-58        
RET (V804L), Active R02-12BG IGF1Rtide I15-58        
RET (Y791F), Active R02-12CG Abltide A02-58        
RIPK2, Active R08-11G     MBP Protein M42-51N    
RIPK3, Active R09-10G     MBP Protein M42-51N    
RIPK5, Active R27-10G     MBP Protein M42-51N    
ROCK1, Active R10-11G S6K Substrate S05-58        
ROCK2, Active R11-11G S6K Substrate S05-58        
ROCK2, Active R11-11H S6K Substrate S05-58        
RON, Active M58-11G Axltide A16-58        
ROR1, Active R12-11G     MBP Protein M42-51N    
ROR2, Active R13-11G     MBP Protein M42-51N    
ROS1, Active R14-11G IGF1Rtide I15-58        
RSK1, Active R15-10G S6K Substrate S05-58     Anti-RSK1 R15-63R
Anti-RSK (pan) R15-63BR
RSK2, Active R17-10G RSK Substrate S06-58     Anti-RSK (pan) R15-63BR
RSK3, Active R16-10G RSK Substrate S06-58     Anti-RSK (pan) R15-63BR
RSK4, Active R20-10G RSK Substrate S06-58     Anti-RSK (pan) R15-63BR
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S

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
SGK1, Active S06-11G Akt (SGK) Substrate A08-58        
SGK2, Active S07-10G Akt (SGK) Substrate A08-58        
SGK3, Active S08-10G Akt (PKB) Substrate A05-58        
SIK, Active S14-11H AMARA Peptide A11-58        
SIK3, Active S12-11G AMARA Peptide A11-58        
SLK, Active S11-10G     Histone H3 Protein H12-54N    
SOK1, Active S43-10G     MBP Protein M42-51N    
SPHK1, Active S17-10G Sphingosine [lipid substrate]          
SPHK2, Active S18-10G Sphingosine [lipid substrate]          
SRC, Active S19-10G SRC Substrate S30-58        
SRC, Active S19-18G SRC Substrate S30-58        
SRMS, Active S20-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
SRPK1, Active S21-10G     MBP Protein M42-51N    
SRPK2, Active S22-10G     MBP Protein M42-51N    
STK3, Active S24-10G     MBP Protein M42-54G    
STK19, Active S35-10G CREBtide C50-58        
STK32B (YANK2), Active Y04-10G     MBP Protein M42-51N    
STK32C(YANK3), Active Y05-11G     MBP Protein M42-51N    
STK33, Active S46-10G     MBP Protein M42-51N    
STK36, Active S48-11G     MBP Protein M42-51N    
STK39 (STLK3), Active S51-10H     MBP Protein M42-51N    
SYK, Active S52-10G Poly (4:1 Glu, Tyr) Peptide P61-58        
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T

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
TAK1-TAB1, Active M15-13G     MBP Protein M42-51N    
TAOK1, Active T24-11G     MBP Protein M42-51N    
TAOK2, Active T25-11G     MBP Protein M42-51N    
TAOK3, Active T26-11G PKCtide P15-58        
TBK1, Active T02-10G     MBP Protein M42-51N    
TEC, Active T03-10G     MBP Protein M42-51N    
TESK2, Active T06-10G     Cofilin 1 Protein C37-54H    
TGFBR1 (ALK5), Active T07-11G TGFBR1 Peptide T36-58        
TGFBR2, Active T08-11G     MBP Protein M42-51N    
TIE2, Active T04-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
TLK1, Active T10-10G     Histone H3 Protein H12-54N    
TLK2, Active T11-11G     Casein Protein C03-54N    
TNIK, Active T27-11G     MBP Protein M42-51N    
TOPK, Active T14-10G     MBP Protein M42-51N    
TRKA, Active N16-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
TRKB, Active N17-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
TRKC, Active N18-11H Poly (4:1 Glu, Tyr) Peptide P61-58        
TSSK1B, Active S40-10BG CHKtide C10-58        
TSSK2, Active S38-10G     MBP Protein M42-51N    
TTBK2, Active T18-11G     MBP Protein M42-51N    
TTK, Active T20-10G     MBP Protein M42-51N    
TXK, Active T19-11G     MBP Protein M42-54G    
TYK2 (JTK1), Active T21-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
TYRO3, Active T22-11G Poly (4:1 Glu, Tyr) Peptide P61-58        
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U

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
ULK1, Active U01-11G     MBP Protein M42-51N    
ULK2, Active U02-11G     MBP Protein M42-51N    
ULK3, Active U03-10H     Casein, Dephosphorylated C03-54BN    
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V

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
VRK1, Active V01-10G     Casein, Dephosphorylated C03-54BN    
VRK2, Active V02-11G     Casein Protein C03-54N    
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W

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
WNK1, Active W02-11G     MBP Protein M42-51N    
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Y

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
YES1, Active Y01-10G Poly (4:1 Glu, Tyr) Peptide P61-58        
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Z

活性型キナーゼ  ペプチド基質 タンパク質基質 抗体
品名 品番 品名 品番 品名 品番 品名 品番
ZAK, Active Z01-10G     MBP Protein M42-51N    
ZAP70, Active Z02-10G Poly (4:1 Glu, Tyr) Peptide P61-58      
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