Ann-Marie Baker, PhD Center for Tumor Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London |
Characterizing LGR5 stem cells in colorectal adenomas and carcinomas Overcoming the limitations of antibody-based detection methods |
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"LGR5 mRNA に対する RNAscope プローブを使用する事で、信頼性のある抗体を使用せずとも LGR5 の局在を解析することが出来ました。"
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Dr. Alexey Pronin Researcher at the University of Miami, Fl |
Exploring GPCR expression in the eye From discovery with NGS to spatial and quantitative expression confirmation with RNAscope® technology |
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"RNAscope は複数の遺伝子を同時に検出できるので、RT-PCR で発見した複数の遺伝子が同一細胞内で発現しているのか調べる事が出来ました。これは他の手法では得ることが難しい非常に価値ある情報です。"
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Nallasivam Palanisamy, MSc., MPhil., PhD. Associate Scientist, Henry Ford Health System, Vattikutti Urology Institute, Medical Group Urology - Prostate Cancer Research Associate Research Professor (Adjunct), Department of Pathology, Michigan Center for Translational Pathology University of Michigan |
Development of Prostate Cancer Personalized Medicine Advancing analysis of prostate tumor molecular heterogeneity by combined immunohistochemistry and novel RNA in situ hybridization |
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"RNAscope のプローブデザインと検出技術により、私の研究室ではたくさんの遺伝子を高特異性かつ高感度に検出することに成功しています。RNAscope 以外で FFPE 組織中の RNA を信頼性高く検出する方法はありません。"
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Rohit Mehra, M.D. Assistant Professor of Pathology, University of Michigan Hospital and Health Systems. |
Realizing the potential of long noncoding RNA as a cancer biomarker From NGS discovery to validation with RNA In Situ Hybridization |
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"RNAscope は迅速・簡便なアッセイです。この技術を用いれば、目的組織内の遺伝子発現をダイレクトに可視化できます。欲しい情報はたった 4um の FFPE 切片の中にあります。"
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Patricia Pesavento, DVM, PhD Professor of Pathology, Microbiology & Immunology |
Insights into viral pathogenesis Determination of causation by highly sensitive and specific viral RNA detection and localization with RNAscope® ISH |
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"RNAscope の超高感度アッセイは、ウイルスの疾患への関与について信頼性ある結果を得るためには、本当に掛け替えのないアッセイです。"
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Saskia Smits, Ph.D. Senior Postdoctoral Scientist 
Sarah Getu Technician Department of Viroscience, Erasmus MC |
Detecting a Novel Circovirus in Foxes with Meningoencephalitis How custom RNAscope® assay probes are enhancing viral understanding |
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The burden of infectious diseases on human health worldwide has markedly increased over the past few decades, and most of these emerging events are caused by viruses originating from the animal world. Understanding the roots of viral behavior in animal hosts is therefore vital, and this is a primary focus of Sarah Getu’s and Saskia Smits’s work at the Department of Viroscience, Erasmus MC. They here explain how the creation of a custom RNAscope® in situ hybridization (ISH) probe allowed them to localize a newly discovered circovirus to neurologic lesions in foxes, providing valuable information to support causation.
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技術情報
Advanced Cell Diagnostics（ADC）社 RNAscope® 技術情報
記事ID ： 16884
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