LIPID MAPS：リピドミクスの発見を促進する

SCIENCE SIGNALING
5 May 2026 Vol 19, Issue 936
DOI: 10.1126/scisignal.aeg3389

Lauren Cockayne¹, Matthew J. Conroy¹, Chetin Baloglu², Eoin Fahy³, Gerhard Hagn⁴, Oswald Quehenberger⁵, Aaron M. Armando⁵, Gabriele Lombardi Bendoula⁶, Jean-Marie Galano⁷, Ángel Sánchez-Illana^{7, 8}, Thierry Durand⁷, Nadja Kampschulte⁹, Paul D. Kennedy¹⁰, Miguel Gijón¹⁰, Hiroshi Tsugawa^{11, 12}, Makoto Arita¹¹, Kirk Maxey¹⁰, Meghan Truskowski¹⁰, Ondrej Kuda¹³, Shazia Khan¹⁴, Natalie Z. M. Homer¹⁴, Yuki Matsuzawa¹², Rosario Domingues¹⁵, Peter J. Meikle¹⁶, Corey Giles¹⁶, Kevin Huynh¹⁶, Robert C. Murphy¹⁷, Zidan Wang¹⁸, Yu Xia¹⁸, Xue Li Guan^{19, 20}, Kim Ekroos²¹, Gerhard Liebisch²², Alfred H. Merrill Jr.²³, Andrea F. Lopez-Clavijo²⁴, Dominic Campopiano²⁵, Craig E. Wheelock^{4, 26}, Shankar Subramaniam³, Robert Andrews¹, Laura Goracci²⁷, Zhixu Ni²⁸, Maria Fedorova⁶, Simon Andrews², William Griffiths²⁹, Ruth Andrew¹⁴, Edward A. Dennis^{5, 30}, Valerie B. O’Donnell^{1, *}

1. ¹ Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff, Wales, UK.
2. ² Babraham Institute, Babraham Research Campus, Cambridge, UK.
3. ³ Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
4. ⁴ Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
5. ⁵ Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
6. ⁶ Center of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.
7. ⁷ Institut des Biomolécules Max Mousseron (IBMM), Pôle Chimie Balard Recherche, CNRS, Université de Montpellier, ENSCN, Montpellier, France.
8. ⁸ Department of Analytical Chemistry, University of Valencia, Burjassot, Spain.
9. ⁹ School of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal, Germany.
10. ¹⁰ Cayman Chemical Company, Ann Arbor, MI, USA.
11. ¹¹ RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan.
12. ¹² Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.
13. ¹³ Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
14. ¹⁴ Institute of Neurosciences and Cardiovascular Research, University of Edinburgh, Edinburgh, Scotland, UK.
15. ¹⁵ Department of Chemistry, University of Aveiro, Aveiro, Portugal.
16. ¹⁶ Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
17. ¹⁷ Department of Pharmacology, University of Colorado Denver, Denver, CO, USA.
18. ¹⁸ MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, China.
19. ¹⁹ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
20. ²⁰ Novo Nordisk Foundation Centre for Metabolic Disease Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
21. ²¹ Lipidomics Consulting Ltd., Esbo, Finland.
22. ²² Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
23. ²³ School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
24. ²⁴ CRUK Cambridge Institute, Cambridge University, Cambridge, UK.
25. ²⁵ School of Chemistry, University of Edinburgh, Edinburgh, Scotland, UK.
26. ²⁶ Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.
27. ²⁷ Department of Chemistry, Biology, and Biotechnology, University of Perugia, Perugia, Italy.
28. ²⁸ Institute of Data and Information (iDI), Tsinghua Shenzhen International Graduate School, Shenzhen, China.
29. ²⁹ Swansea University Medical School, Singleton Park, Swansea, Wales, UK.
30. ³⁰ Department of Biochemistry and Molecular Biophysics and Department of Chemistry, University of California, San Diego, La Jolla, CA, USA.
31. * Corresponding author. Email: o-donnellvb@cardiff.ac.uk

要約

リピドミクスの25周年が近づく中で、本稿では脂質研究が長年にわたりどのように成熟してきたのかを検討すると同時に、この多様な、生命にとってきわめて重要な生体分子を研究するわれわれの能力を高めている、新たな技術革新に注目する。とくに、ELIXIR Core Data ResourceであるLIPID MAPSを通して自由に利用できる、実績ある研究者にも若手研究者にも有益なコミュニティ主導のオープンアクセスデータベース、ソフトウェアおよび教材を紹介する。