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- 液体クロマトグラフィー質量分析によるオキシリピンの分析に関する技術的推奨事項
液体クロマトグラフィー質量分析によるオキシリピンの分析に関する技術的推奨事項
Technical recommendations for analyzing oxylipins by liquid chromatography–mass spectrometry
SCIENCE SIGNALING
20 May 2025 Vol 18, Issue 887
DOI: 10.1126/scisignal.adw1245
Nils Helge Schebb1, *, Nadja Kampschulte1, Gerhard Hagn2, Kathrin Plitzko1, Sven W. Meckelmann3, Soumita Ghosh4, Robin Joshi4, Julia Kuligowski5, Dajana Vuckovic6, Marina T. Botana2, 7, Ángel Sánchez-Illana8, Fereshteh Zandkarimi9, Aditi Das10, Jun Yang11, Louis Schmidt12, Antonio Checa2,
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Helen M. Roche13, 14, Aaron M. Armando15, Matthew L. Edin16, Fred B. Lih16, Juan J. Aristizabal-Henao17, Sayuri Miyamoto18, Francesca Giuffrida19, Arieh Moussaieff20, Rosário Domingues21, Michael Rothe22, Christine Hinz23, Ujjalkumar Subhash Das4, Katharina M. Rund1, Ameer Y. Taha24, Robert K. Hofstetter25, Markus Werner25, Oliver Werz25, Astrid S. Kahnt26, Justine Bertrand-Michel27, Pauline Le Faouder27, Robert Gurke28, 29, 30, Dominique Thomas28, 29, 30, Federico Torta31, 32, Ivana Milic33, Irundika H. K. Dias34, Corinne M. Spickett33, Denise Biagini35, Tommaso Lomonaco35, Helena Idborg36, Jun-Yan Liu37, Maria Fedorova38, David A. Ford39, Anne Barden40, Trevor A. Mori40, Paul D. Kennedy41, Kirk Maxey41, Julijana Ivanisevic42, Hector Gallart-Ayala42, Cécile Gladine43, Markus Wenk44, 45, Jean-Marie Galano46, Thierry Durand46, Ken D. Stark47, Coral Barbas48, Ulrike Garscha12, Stacy L. Gelhaus49, 50, Uta Ceglarek51, Nicolas Flamand52, Julian L. Griffin53, Robert Ahrends54, Makoto Arita55, Darryl C. Zeldin16, Francisco J. Schopfer50, Oswald Quehenberger15, Randall Julian56, Anna Nicolaou57, Ian A. Blair58, Michael P. Murphy59, Bruce D. Hammock11, Bruce Freeman50, Gerhard Liebisch60, Charles N. Serhan61, Harald C. Köfeler62, Per-Johan Jakobsson36, Dieter Steinhilber26, Michael H. Gelb63, Michal Holčapek64, Ruth Andrew65, Martin Giera66, Garret A. FitzGerald4, Robert C. Murphy67, John W. Newman68, Edward A. Dennis15, Kim Ekroos69, Ginger L. Milne70, Miguel A. Gijón41, Hubert W. Vesper71, Craig E. Wheelock2, 72, Valerie B. O’Donnell73
- 1 School of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal, Germany.
- 2 Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
- 3 Applied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany.
- 4 Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
- 5 Neonatal Research Group, Health Research Institute La Fe (IIS La Fe), Valencia, Spain.
- 6 Department of Chemistry and Biochemistry, Concordia University, Montreal, Canada.
- 7 School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.
- 8 Department of Analytical Chemistry, University of Valencia, Burjassot, Spain.
- 9 Mass Spectrometry Core Facility, Department of Chemistry, Columbia University, New York, NY, USA.
- 10 School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
- 11 Department of Entomology, University of California, Davis, CA, USA.
- 12 Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, Greifswald, Germany.
- 13 Nutrigenomics Research Group, UCD Conway Institute, School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland.
- 14 Institute for Global Food Security, Queen’s University Belfast, Belfast, Northern Ireland.
- 15 Department of Pharmacology and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA, USA.
- 16 Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA.
- 17 BPG Bio, Framingham, MA, USA.
- 18 Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
- 19 Nestlé Institute of Food Safety and Analytical Sciences, Société des Produits Nestlé, Lausanne, Switzerland.
- 20 Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
- 21 Department of Chemistry, University of Aveiro, Aveiro, Portugal.
- 22 Lipidomix GmbH, Berlin, Germany.
- 23 Shimadzu UK Ltd., Milton Keynes, UK.
- 24 Department of Food Science and Technology, University of California, Davis, CA, USA.
- 25 Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Jena, Germany.
- 26 Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
- 27 MetaboHUB-MetaToul, I2MC, Université de Toulouse, Inserm, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France.
- 28 Faculty of Medicine, Institute of Clinical Pharmacology, Goethe University Frankfurt, Frankfurt am Main, Germany.
- 29 Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.
- 30 Fraunhofer Cluster of Excellence of Immune Mediate Diseases CIMD, Frankfurt am Main, Germany.
- 31 Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
- 32 Singapore Lipidomics Incubator, Life Sciences Institute and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
- 33 School of Biosciences & Aston Institute for Membrane Excellence, Aston University, Aston Triangle, Birmingham, UK.
- 34 Aston Medical School, College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham, UK.
- 35 Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy.
- 36 Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
- 37 Center for Novel Target & Therapeutic Intervention, College of Pharmacy, Chongqing Medical University, Chongqing, P. R. China.
- 38 Center of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.
- 39 Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St. Louis, MO, USA.
- 40 Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia.
- 41 Cayman Chemical Company, Ann Arbor, MI, USA.
- 42 Metabolomics and Lipidomics Platform, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
- 43 Université Clermont Auvergne, INRAE, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France.
- 44 College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
- 45 Long Loo Lin School of Medicine, National University of Singapore.
- 46 Institut des Biomolécules Max Mousseron (IBMM), Pôle Chimie Balard Recherche, CNRS, Université de Montpellier, ENSCN, Montpellier, France.
- 47 Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Canada.
- 48 Centre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, CEU San Pablo University, Madrid, Spain.
- 49 Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA.
- 50 Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
- 51 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig Medical Center, Leipzig, Germany.
- 52 Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Quebec, Département de médecine, Faculté de médecine, Université Laval, Quebec City, Canada.
- 53 Rowett Institute, School of Medicine, Medical Science and Nutrition, University of Aberdeen, Aberdeen, UK.
- 54 Department of Analytical Chemistry, University of Vienna, Vienna, Austria.
- 55 RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan.
- 56 Indigo BioAutomation, Carmel, IN, USA.
- 57 Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
- 58 Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
- 59 Medical Research Council Mitochondrial Biology Unit and Department of Medicine, University of Cambridge, Cambridge, UK.
- 60 Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
- 61 Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Hale Building for Transformative Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.
- 62 Core Facility Mass Spectrometry, ZMF, Medical University of Graz, Graz, Austria.
- 63 Department of Chemistry, University of Washington, Seattle, WA, USA.
- 64 Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic.
- 65 Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK.
- 66 Leiden University Medical Center, Leiden, Netherlands.
- 67 Department of Pharmacology, University of Colorado Denver, Denver, CO, USA.
- 68 USDA ARS Western Human Nutrition Research Center and Department of Nutrition, University of California, Davis, CA, USA.
- 69 Lipidomics Consulting Ltd., Esbo, Finland.
- 70 Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Centre, Nashville, TN, USA.
- 71 Centers for Disease Control and Prevention, Atlanta, GA, USA.
- 72 Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.
- 73 School of Medicine, Cardiff University, Heath Park, Cardiff, UK.
- * Corresponding author. Email: nils@schebb-web.de
要約
いくつかのオキシリピンは、健康と疾患のさまざまな側面を制御する強力な脂質メディエーターであり、液体クロマトグラフィー質量分析(LC-MS)を用いたその定量分析には多くの技術的課題がある。リピドミクス分野に携わる者として、われわれは、LC-MSによるオキシリピン定量におけるベストプラクティスを確実にするための技術的推奨事項を策定した。