Reviews バックナンバー 2008〜2009年 

(08 December 2009)
 

ホスファターゼの暗号を解く:ドッキング相互作用が基質特異性を決定

Cracking the Phosphatase Code: Docking Interactions Determine Substrate Specificity
Jagoree Roy and Martha S. Cyert*
Sci. Signal, 8 December 2009 Vol. 2, Issue 100, p. re9[DOI: 10.1126/scisignal.2100re9]
日本語要約][英文原文

(20 October 2009)
 

アルツハイマー病におけるGタンパク質共役受容体とコリン作動性機能障害とAβ毒性

G Protein-Coupled Receptors, Cholinergic Dysfunction, and Aβ Toxicity in Alzheimer’s Disease
Amantha Thathiah* and Bart De Strooper*
Sci. Signal, 20 October 2009 Vol. 2, Issue 93, p. re8[DOI: 10.1126/scisignal.293re8
日本語要約][英文原文

(29 September 2009)
 

求電子物質とタンパク質の反応による酸化還元シグナル伝達

Transduction of Redox Signaling by Electrophile-Protein Reactions
Tanja K. Rudolph1,2 and Bruce A. Freeman1*
Sci. Signal, 29 September 2009 Vol. 2, Issue 90, p. re7[DOI: 10.1126/scisignal.290re7]
日本語要約][英文原文

(08 September 2009)
 

グリオーマにおける発がん性EGFRシグナル伝達ネットワーク

Oncogenic EGFR Signaling Networks in Glioma
Paul H. Huang1*, Alexander M. Xu2, and Forest M. White2,3
Sci. Signal, 8 September 2009 Vol. 2, Issue 87, p. re6[DOI: 10.1126/scisignal.287re6]
日本語要約][英文原文

(01 September 2009)
 

シナプスにおけるストレス:ニューロン膜での副腎ステロイドのシグナル伝達機構

Stress at the Synapse: Signal Transduction Mechanisms of Adrenal Steroids at Neuronal Membranes
Eric M. Prager and Luke R. Johnson*
Sci. Signal, 1 September 2009 Vol. 2, Issue 86, p. re5[DOI: 10.1126/scisignal.286re5]
日本語要約][英文原文

(16 June 2009)
 

ビタミンDステロール‐ビタミンD受容体のアンサンブルモデルがゲノム応答シグナル伝達と迅速応答シグナル伝達の両方についてのユニークな洞察を与える

The Vitamin D Sterol-Vitamin D Receptor Ensemble Model Offers Unique Insights into Both Genomic and Rapid-Response Signaling
Mathew T. Mizwicki1* and Anthony W. Norman1,2
Sci. Signal, 16 June 2009 Vol. 2, Issue 75, p. re4[DOI: 10.1126/scisignal.275re4]
日本語要約][英文原文

(26 May 2009)
 

免疫、代謝、血管新生、および行動に関与するスカベンジャー受容体CD36

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior
Roy L. Silverstein* and Maria Febbraio
Sci. Signal, 26 May 2009 Vol. 2, Issue 72, p. re3[DOI: 10.1126/scisignal.272re3]
日本語要約][英文原文

(24 February 2009)
 

VEGFR1リガンドによる血管新生の正および負の調節

Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands
Yihai Cao*
Sci. Signal, 24 February 2009 Vol. 2, Issue 59, p. re1[DOI: 10.1126/scisignal.259re1]
日本語要約][英文原文

(23 December 2008)
 

リン酸化トレオニン特異的FHAドメインの構造と機能

Structure and Function of the Phosphothreonine-Specific FHA Domain
Anjali Mahajan1, Chunhua Yuan2, Hyun Lee1,3, Eric S.-W. Chen3,4,5, Pei-Yu Wu5, and Ming-Daw Tsai1,2,3,4,5*
Sci. Signal, 23 December 2008 Vol. 1, Issue 51, p. re12[DOI: 10.1126/scisignal.151re12]
日本語要約][英文原文

(09 December 2008)
 

分化細胞からの新規の器官形成:根粒器官形成

De Novo Organ Formation from Differentiated Cells: Root Nodule Organogenesis
Martin Crespi* and Florian Frugier
Sci. Signal, 9 December 2008 Vol. 1, Issue 49, p. re11[DOI: 10.1126/scisignal.149re11]
日本語要約][英文原文

(04 November 2008)
 

NAADP:万能Ca2+ トリガー

NAADP: A Universal Ca2+ Trigger
Andreas H. Guse1* and Hon Cheung Lee2
Sci. Signal, 4 November 2008 Vol. 1, Issue 44, p. re10[DOI: 10.1126/scisignal.144re10]
日本語要約][英文原文

(22 July 2008)
 

病原体にハイジャックされた因子を標的とする宿主指向性薬物

Host-Directed Drug Targeting of Factors Hijacked by Pathogens
Anita Schwegmann and Frank Brombacher*
Sci. Signal, 22 July 2008 Vol. 1, Issue 29, p. re8[DOI: 10.1126/scisignal.129re8]
日本語要約][英文原文

(15 July 2008)
 

エタノールの分子標的

Ethanol’s Molecular Targets
R. Adron Harris1*, James R. Trudell2, and S. John Mihic1
Sci. Signal, 15 July 2008 Vol. 1, Issue 28, p. re7[DOI: 10.1126/scisignal.128re7]
日本語要約][英文原文

(08 July 2008)
 

細胞シグナル伝達における組織メタロプロテアーゼ阻害物質:メタロプロテアーゼ非依存性の生物活性

Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological Activities
William G. Stetler-Stevenson*
Sci. Signal, 8 July 2008 Vol. 1, Issue 27, p. re6[DOI: 10.1126/scisignal.127re6]
日本語要約][英文原文

(24 June 2008)
 

細胞内でのヘテロ三量体Gタンパク質の解離

Dissociation of Heterotrimeric G Proteins in Cells
Nevin A. Lambert*
Sci. Signal, 24 June 2008 Vol. 1, Issue 25, p. re5[DOI: 10.1126/scisignal.125re5]
日本語要約][英文原文

(03 June 2008)
 

薬理学的なPKA阻害:すべてが見掛けの作用ではない可能性

Pharmacological PKA Inhibition: All May Not Be What It Seems
Andrew J. Murray*
Sci. Signal, 3 June 2008 Vol. 1, Issue 22, p. re4[DOI: 10.1126/scisignal.122re4]
日本語要約][英文原文

(13 May 2008)
 

亜鉛は神経調節物質か?

Is Zinc a Neuromodulator?
Alan R. Kay1* and Katalin Toth2
Sci. Signal, 13 May 2008 Vol. 1, Issue 19, p. re3[DOI: 10.1126/stke.119re3]
日本語要約][英文原文

(22 April 2008)
 

Ephタンパク質ファミリーの時代到来:さらなる混乱、解明あるいは複雑化?

Eph, a Protein Family Coming of Age: More Confusion, Insight, or Complexity?
Martin Lackmann1* and Andrew W. Boyd2
Sci. Signal, 22 April 2008 Vol. 1, Issue 15, p. re2[DOI: 10.1126/stke.115re2]
日本語要約][英文原文

(08 April 2008)
 

中枢神経系におけるカルパイン:シナプス機能から神経毒性まで

Calpain in the CNS: From Synaptic Function to Neurotoxicity
Jing Liu1*, Ming Cheng Liu2,3, and Kevin K. W. Wang1,2,3*
Sci. Signal, 8 April 2008 Vol. 1, Issue 14, p. re1[DOI: 10.1126/stke.114re1]
日本語要約][英文原文