| (23 December 2008) |
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mAKAPはHIF-1αの酸素依存性の制御を区画化する
mAKAP Compartmentalizes Oxygen-Dependent Control of HIF-1α
Wei Wong1, April S. Goehring1, Michael S. Kapiloff2, Lorene K. Langeberg3, and John D. Scott3*
Sci. Signal, 23 12 2008 Vol. 1, Issue 51, p. ra18[DOI: 10.1126/scisignal.2000026] |
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［日本語要約］［英文原文］ |
| (23 December 2008) |
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マクロファージにおいて、I 型IL-4RはIRS-2を選択的に活性化して標的遺伝子の発現を誘導する
Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages
Nicola M. Heller1,2, Xiulan Qi1,2, Ilkka S. Junttila3, Kari Ann Shirey2, Stefanie N. Vogel2, William E. Paul3, and Achsah D. Keegan1,2*
Sci. Signal, 23 12 2008 Vol. 1, Issue 51, p. ra17[DOI: 10.1126/scisignal.1164795] |
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［日本語要約］［英文原文］ |
| (09 December 2008) |
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メタ遺伝子像の解析によって腎臓器官形成における特異的な遷移を明らかにする
Analysis of Metagene Portraits Reveals Distinct Transitions During Kidney Organogenesis
Igor F. Tsigelny1,2*† , Valentina L. Kouznetsova3† , Derina E. Sweeney3, Wei Wu3, Kevin T. Bush3, and Sanjay K. Nigam3,4,5,6*
Sci. Signal, 09 12 2008 Vol. 1, Issue 49, p. ra16[DOI: 10.1126/scisignal.1163630] |
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［日本語要約］［英文原文］ |
| (25 November 2008) |
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γ-セクレターゼはLRP1のプロセシングを通じて炎症応答を抑制する
γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1
Kai Zurhove1,2, Chikako Nakajima1,2, Joachim Herz2,3, Hans H. Bock1,2, and Petra May1,2*
Sci. Signal, 25 11 2008 Vol. 1, Issue 47, p. ra15[DOI: 10.1126/scisignal.1164263] |
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［日本語要約］［英文原文］ |
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UVBによる損傷に応答するJIP-3からJNKへのシグナル伝達軸の上流活性化因子としてのROCK1の同定
Identification of ROCK1 as an Upstream Activator of the JIP-3 to JNK Signaling Axis in Response to UVB Damage
Pat P. Ongusaha1, Hank H. Qi2, Lakshmi Raj1, Young-Bum Kim3, Stuart A. Aaronson4, Roger J. Davis5, Yang Shi2, James K. Liao6, and Sam W. Lee1*
Sci. Signal, 25 11 2008 Vol. 1, Issue 47, p. ra14[DOI: 10.1126/scisignal.1161938] |
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［日本語要約］［英文原文］ |
| (11 November 2008) |
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CriptoはNodalを初期エンドソームの境界膜に局在化させる
Cripto Localizes Nodal at the Limiting Membrane of Early Endosomes
Marie-Helene Blanchet1, J. Ann Le Good1, Viola Oorschot2, Stephane Baflast1, Gabriella Minchiotti3, Judith Klumperman2, and Daniel B. Constam1*
Sci. Signal, 11 11 2008 Vol. 1, Issue 45, p. ra13[DOI: 10.1126/scisignal.1165027] |
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［日本語要約］［英文原文］ |
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統合的な分子スクリーニングによって明らかにされたWnt/β-カテニンシグナル伝達の新たな調節因子
New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening
Michael B. Major1*, Brian S. Roberts2*, Jason D. Berndt1, Shane Marine3, Jamie Anastas1, Namjin Chung3, Marc Ferrer3, XianHua Yi4, ...
Sci. Signal, 11 11 2008 Vol. 1, Issue 45, p. ra12[DOI: 10.1126/scisignal.2000037] |
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［日本語要約］［英文原文］ |
| (28 October 2008) |
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融合可能状態へと誘導するマクロファージのプログラミングにおけるDAP12シグナル伝達の重要な役割
Essential Role of DAP12 Signaling in Macrophage Programming into a Fusion-Competent State
Laura Helming1*, Elena Tomasello2,3,4, Themis R. Kyriakides5,6,7, Fernando O. Martinez1, Toshiyuki Takai8,9, Siamon Gordon1†‡, and Eric Vivier2,3,4,10†‡
Sci. Signal, 28 10 2008 Vol. 1, Issue 43, p. ra11[DOI: 10.1126/scisignal.1159665] |
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［日本語要約］［英文原文］ |
| (21 October 2008) |
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ディジタル回路の故障診断工学により複雑な細胞経路の脆弱分子を特定できる
Fault Diagnosis Engineering of Digital Circuits Can Identify Vulnerable Molecules in Complex Cellular Pathways
Ali Abdi1, Mehdi Baradaran Tahoori2, and Effat S. Emamian3*†
Sci. Signal, 21 10 2008 Vol. 1, Issue 42, p. ra10[DOI: 10.1126/scisignal.2000008] |
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［日本語要約］［英文原文］ |
| (14 October 2008) |
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BDNFは、JAK/STAT経路の活性化を介してGABAA受容体の転写を選択的に調節する
BDNF Selectively Regulates GABAA Receptor Transcription by Activation of the JAK/STAT Pathway
Ingrid V. Lund1*, Yinghui Hu3,4*, YogendraSinh H. Raol2, Rebecca S. Benham3,4, Ramona Faris4,5, Shelley J. Russek,4†, and Amy R. Brooks-Kayal6,7†
Sci. Signal, 14 10 2008 Vol. 1, Issue 41, p. ra9[DOI: 10.1126/scisignal.1162396] |
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［日本語要約］［英文原文］ |
| |
ニューロンカルシウムセンサーVILIP1によるP2X2受容体の調節
Regulation of P2X2 Receptors by the Neuronal Calcium Sensor VILIP1
Severine Chaumont1,2,3,4,5*, Vincent Compan3,4,5, Estelle Toulme1,2, Esther Richler1,2, Gary D. Housley6, Francois Rassendren3,4,5, and Baljit S. Khakh1,2*†
Sci. Signal, 14 10 2008 Vol. 1, Issue 41, p. ra8[DOI: 10.1126/scisignal.1162329] |
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［日本語要約］［英文原文］ |
| (30 September 2008) |
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キノームsiRNAスクリーンは繊毛形成およびヘッジホッグシグナル伝達の調節因子を同定する
Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction
Marie Evangelista1*, Tze Yang Lim1, James Lee1, Leon Parker2, Amir Ashique1, Andrew S. Peterson1, Weilan Ye2, David P. Davis1, and Frederic J. de Sauvage1*
Sci. Signal, 30 09 2008 Vol. 1, Issue 39, p. ra7[DOI: 10.1126/scisignal.1162925] |
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［日本語要約］［英文原文］ |
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パネキシン1ヘミチャネルを通して放出されるATPによるT細胞活性化のプリン作動性調節
Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels
Ursula Schenk1, Astrid M. Westendorf2, Enrico Radaelli3, Anna Casati1,4, Micol Ferro1, Marta Fumagalli5, Claudia Verderio6, Jan Buer2, Eugenio Scanziani3, and Fabio Grassi1*
Sci. Signal, 30 09 2008 Vol. 1, Issue 39, p. ra6[DOI: 10.1126/scisignal.1160583] |
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［日本語要約］［英文原文］ |
| (23 September 2008) |
| |
Nedd4はIGF-1シグナル伝達の調節により動物の成長を制御する
Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling
Sci. Signal, 23 09 2008 Vol. 1, Issue 38, p. ra5[DOI: 10.1126/scisignal.1160940] |
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［日本語要約］［英文原文］ |
| (16 September 2008) |
| |
ケモカインSDF-1/CXCL12によるCXCR4硫酸化チロシン認識の構造的基盤
Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12
Christopher T. Veldkamp, Christoph Seibert, Francis C. Peterson, Norberto B. De la Cruz, John C. Haugner III, Harihar Basnet, Thomas P. Sakmar, and Brian F. Volkman
Sci. Signal, 16 09 2008 Vol. 1, Issue 37, p. ra4[DOI: 10.1126/scisignal.1160755] |
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［日本語要約］［英文原文］ |
| (09 September 2008) |
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ホスホイノシチド3-キナーゼp110βの活性：代謝および乳腺がんに重要な役割を果たすが、発生では役割はない
Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development
Sci. Signal, 09 09 2008 Vol. 1, Issue 36, p. ra3[DOI: 10.1126/scisignal.1161577] |
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［日本語要約］［英文原文］ |
| (02 September 2008) |
| |
リン酸化反応の図譜
An Atlas of Phosphorylation
Sci. Signal, 02 09 2008 Vol. 1, Issue 35, p. ra2[DOI: 10.1126/scisignal.1159433] |
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［日本語要約］［英文原文］ |
| |
骨のセンサー
Editor's Summary
Bone Censor
Sci. Signal, 02 09 2008 Vol. 1, Issue 35, p. ra1[DOI: 10.1126/scisignal.1159945] |
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［日本語要約］［英文原文］ |
