Research Article バックナンバー 2009年 

(22 December 2009)
 

Cblは初期エンドソームの融合を調節することによってEGFRの運命を制御する

Cbl Controls EGFR Fate by Regulating Early Endosome Fusion
Gina D. Visser Smit1*†, Trenton L. Place1*, Sara L. Cole2*†, Kathryn A. Clausen1†, Soumya Vemuganti1†, Guojuan Zhang2, John G. Koland1, and Nancy L. Lill2†‡
Sci. Signal, 22 December 2009 Vol. 2, Issue 102, p. ra86[DOI: 10.1126/scisignal.2000217]

  日本語要約][英文原文
 

PTENによる腫瘍抑制には、PKR-eIF2αリン酸化経路の活性化が必要である

Tumor Suppression by PTEN Requires the Activation of the PKR-eIF2α Phosphorylation Pathway
Zineb Mounir1,2, Jothi Latha Krishnamoorthy1, Gavin P. Robertson3, Donalyn Scheuner4, Randal J. Kaufman4, Maria-Magdalena Georgescu5, and Antonis E. Koromilas1,6*
Sci. Signal, 22 December 2009 Vol. 2, Issue 102, p. ra85[DOI: 10.1126/scisignal.2000389]

  日本語要約][英文原文
 

リジン脱アセチル化酵素HDAC6による上皮増殖因子受容体輸送の調節

Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6
Yonathan Lissanu Deribe1, Philipp Wild1, Akhila Chandrashaker2, Jasna Curak3, Mirko H. H. Schmidt1,4, Yannis Kalaidzidis2,5, Natasa Milutinovic3, ...
Sci. Signal, 22 December 2009 Vol. 2, Issue 102, p. ra84[DOI: 10.1126/scisignal.2000576]

  日本語要約][英文原文
(15 December 2009)
 

T細胞の発達および活性化におけるVav1のヌクレオチド交換活性の機能

Function of the Nucleotide Exchange Activity of Vav1 in T Cell Development and Activation
Alexander Saveliev1, Lesley Vanes1, Olga Ksionda1, Jonathan Rapley1,2, Stephen J. Smerdon2, Katrin Rittinger2, and Victor L. J. Tybulewicz1*
Sci. Signal, 15 December 2009 Vol. 2, Issue 101, p. ra83[DOI: 10.1126/scisignal.2000420]

  日本語要約][英文原文
 

Akt-SREBP-1依存性で、ラパマイシン耐性の経路を経由するEGFRシグナル伝達は、脂質合成阻害療法(Antilipogenic Therapy)に対するグリオブラストーマの感受性を高める

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy
Deliang Guo1, Robert M. Prins2, Julie Dang1, Daisuke Kuga1, Akio Iwanami1, Horacio Soto2, Kelly Y. Lin1, Tiffany T. Huang1, David Akhavan1, ...
Sci. Signal, 15 December 2009 Vol. 2, Issue 101, p. ra82[DOI: 10.1126/scisignal.2000446]

  日本語要約][英文原文
(08 December 2009)
 

アポトーシス小体によるマイクロRNA-126の送達はCXCL12依存性の血管保護作用を誘導する

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection
Alma Zernecke1,2*†, Kiril Bidzhekov1*, Heidi Noels1*, Erdenechimeg Shagdarsuren1, Lin Gan3, Bernd Denecke3, Mihail Hristov1, Thomas Köppel4,...
Sci. Signal, 8 December 2009 Vol. 2, Issue 100, p. ra81[DOI: 10.1126/scisignal.2000610]

  日本語要約][英文原文
 

がん遺伝子依存の持続に必要なのはMet活性化経路の一サブセットのみ

Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction
Andrea Bertotti1, Mike F. Burbridge2*, Stefania Gastaldi1*, Francesco Galimi1*, Davide Torti1*, Enzo Medico3, Silvia Giordano1, Simona Corso1,...
Sci. Signal, 8 December 2009 Vol. 2, Issue 100, p. ra80[DOI: 10.1126/scisignal.2000643]

  日本語要約][英文原文
(01 December 2009)
 

RIAMはT細胞においてPLC-γ1の細胞骨格分布と活性化を調節する

RIAM Regulates the Cytoskeletal Distribution and Activation of PLC-γ1 in T Cells
Nikolaos Patsoukis1, Esther M. Lafuente2*, Paul Meraner3, Jin sub Kim1, David Dombkowski4, Lequn Li1, and Vassiliki A. Boussiotis1†
Sci. Signal, 1 December 2009 Vol. 2, Issue 99, p. ra79[DOI: 10.1126/scisignal.2000409]

  日本語要約][英文原文
 

プロテインキナーゼGは褐色脂肪細胞の分化とミトコンドリアのバイオジェネシスを制御する

Protein Kinase G Controls Brown Fat Cell Differentiation and Mitochondrial Biogenesis
Bodo Haas1, Peter Mayer2*, Katja Jennissen1*, Daniela Scholz1, Mauricio Berriel Diaz3, Wilhelm Bloch4, Stephan Herzig3, Reinhard Fässler5...
Sci. Signal, 1 December 2009 Vol. 2, Issue 99, p. ra78[DOI: 10.1126/scisignal.2000511]

  日本語要約][英文原文
(24 November 2009)
 

Ca2+パフはイノシトールトリスリン酸受容体の既存の安定クラスターから生じる

Ca2+ Puffs Originate from Preestablished Stable Clusters of Inositol Trisphosphate Receptors
Ian F. Smith1*, Steven M. Wiltgen1, Jianwei Shuai2, and Ian Parker1,3
Sci. Signal, 24 November 2009 Vol. 2, Issue 98, p. ra77[DOI: 10.1126/scisignal.2000466]
日本語要約][英文原文

 

細胞進化の機能単位としての真核生物のタンパク質ドメイン

Eukaryotic Protein Domains as Functional Units of Cellular Evolution
Jing Jin1*, Xueying Xie2†‡, Chen Chen1‡, Jin Gyoon Park1, Chris Stark, D. Andrew James1, Marina Olhovsky1, Rune Linding, ...
Sci. Signal, 24 November 2009 Vol. 2, Issue 98, p. ra76[DOI: 10.1126/scisignal.2000546]

  日本語要約][英文原文
 

老化造血幹細胞のmTORによる調節と若返り治療

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
Chong Chen1, Yu Liu1, Yang Liu1,2*, and Pan Zheng1,3*
Sci. Signal, 24 November 2009 Vol. 2, Issue 98, p. ra75[DOI: 10.1126/scisignal.2000559]

  日本語要約][英文原文
(17 November 2009)
 

クルーズトリパノソーマは、細胞内の抗アポトーシス戦略として宿主細胞のAktを標的にする

Trypanosoma cruzi Targets Akt in Host Cells as an Intracellular Antiapoptotic Strategy
Marina V. Chuenkova and Mercio PereiraPerrin*
Sci. Signal, 17 November 2009 Vol. 2, Issue 97, p. ra74[DOI: 10.1126/scisignal.2000374]

  日本語要約][英文原文
 

チロシンリン酸化によるPLM2の阻害がワールブルク効果と腫瘍増殖を促進する

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
Taro Hitosugi1, Sumin Kang1, Matthew G. Vander Heiden2, Tae-Wook Chung1, Shannon Elf1, Katherine Lythgoe1, Shaozhong Dong1, Sagar Lonial1, Xu Wang1, ...
Sci. Signal, 17 November 2009 Vol. 2, Issue 97, p. ra73[DOI: 10.1126/scisignal.2000431]

  日本語要約][英文原文
(10 November 2009)
 

タンパク質のS-スルフヒドリル化を介するH2Sシグナル

H2S Signals Through Protein S-Sulfhydration
Asif K. Mustafa1, Moataz M. Gadalla2, Nilkantha Sen1, Seyun Kim1, Weitong Mu1, Sadia K. Gazi1, Roxanne K. Barrow1, Guangdong Yang3, Rui Wang3, ...
Sci. Signal, 10 November 2009 Vol. 2, Issue 96, p. ra72[DOI: 10.1126/scisignal.2000464]

  日本語要約][英文原文
(03 November 2009)
 

GTPアーゼRhoAによる細菌の病原性タンパク質の活性化

Activation of a Bacterial Virulence Protein by the GTPase RhoA
Matthias Christen1*, Lisette H. Coye1*, Jill S. Hontz2, Doris L. LaRock3, Richard A. Pfuetzner1, Megha2, and Samuel I. Miller1,2,3,4†
Sci. Signal, 3 November 2009 Vol. 2, Issue 95, p. ra71[DOI: 10.1126/scisignal.2000430]

  日本語要約][英文原文
 

Rfx4転写因子が繊毛形成の領域制御によりShhシグナル伝達を調節する

The Rfx4 Transcription Factor Modulates Shh Signaling by Regional Control of Ciliogenesis
Amir M. Ashique1, Youngshik Choe2, Mattias Karlen3, Scott R. May4, Khanhky Phamluong1, Mark J. Solloway1, Johan Ericson3, and Andrew S. Peterson1*
Sci. Signal, 3 November 2009 Vol. 2, Issue 95, p. ra70[DOI: 10.1126/scisignal.2000602]

  日本語要約][英文原文
(27 October 2009)
 

複製老化に伴うMKK4存在量の増大は複数のマイクロRNAの協調的減少に関連している

Increased MKK4 Abundance with Replicative Senescence Is Linked to the Joint Reduction of Multiple MicroRNAs
Bernard S. Marasa1, Subramanya Srikantan1, Kiyoshi Masuda1, Kotb Abdelmohsen1, Yuki Kuwano1, Xiaoling Yang1, Jennifer L. Martindale1, Carrie W. Rinker-Schaeffer2, ...
Sci. Signal, 27 October 2009 Vol. 2, Issue 94, p. ra69[DOI: 10.1126/scisignal.2000442]

  日本語要約][英文原文
 

単一のcGMP分子で活性化される非定型CNGチャネルが精子走化性を制御する

An Atypical CNG Channel Activated by a Single cGMP Molecule Controls Sperm Chemotaxis
Wolfgang Bönigk1,2*, Astrid Loogen1*, Reinhard Seifert1*, Nachiket Kashikar1,3, Clementine Klemm4, Eberhard Krause4, Volker Hagen4, Elisabeth Kremmer5, ...
Sci. Signal, 27 October 2009 Vol. 2, Issue 94, p. ra68[DOI: 10.1126/scisignal.2000516]

  日本語要約][英文原文
(20 October 2009)
 

STIM2はニューロンにおいて容量性Ca2+流入を調節し、低酸素性神経細胞死に重要な役割を果たす

STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death
Alejandro Berna-Erro1,2*, Attila Braun1,2*, Robert Kraft3, Christoph Kleinschnitz4, Michael K. Schuhmann4, David Stegner1,2, Thomas Wultsch5, Jens Eilers3,
Sci. Signal, 20 October 2009 Vol. 2, Issue 93, p. ra67[DOI: 10.1126/scisignal.2000522]

  日本語要約][英文原文
 

IL-1シグナル伝達における機構的および時間的に異なる2つのNF-κB活性化経路

Two Mechanistically and Temporally Distinct NF-κB Activation Pathways in IL-1 Signaling
Kohsuke Yamazaki1, Jin Gohda1, Atsuhiro Kanayama2*, Yusei Miyamoto2, Hiroaki Sakurai3, Masahiro Yamamoto4, Shizuo Akira5, Hidetoshi Hayashi6, Bing Su7, ...
Sci. Signal, 20 October 2009 Vol. 2, Issue 93, p. ra66[DOI: 10.1126/scisignal.2000387]

  日本語要約][英文原文
(13 October 2009)
 

ケミカルジェネティックスによって、マウス胚性幹細胞における原始外胚葉形成の活性化因子としてc-Srcが同定される

Chemical Genetics Identifies c-Src as an Activator of Primitive Ectoderm Formation in Murine Embryonic Stem Cells
Malcolm A. Meyn III* and Thomas E. Smithgall
Sci. Signal, 13 October 2009 Vol. 2, Issue 92, p. ra64[DOI: 10.1126/scisignal.2000311]

  日本語要約][英文原文
 

Act1はIL-17シグナル伝達に必要なUボックス型E3ユビキチンリガーゼである

Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling
Caini Liu1*, Wen Qian1*, Youcun Qian1*, Natalia V. Giltiay1, Yi Lu1, Shadi Swaidani1, Saurav Misra2, Li Deng3, Zhijian J. Chen3,4, and Xiaoxia Li1†
Sci. Signal, 13 October 2009 Vol. 2, Issue 92, p. ra63[DOI: 10.1126/scisignal.2000382]

  日本語要約][英文原文
 

Aktアイソフォームによって特異的な調節を受けるマイクロRNAががん細胞のEMTと幹細胞複製を制御する

MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells
Dimitrios Iliopoulos1*, Christos Polytarchou2*, Maria Hatziapostolou2, Filippos Kottakis2, Ioanna G. Maroulakou2, Kevin Struhl1, and Philip N. Tsichlis2†
Sci. Signal, 13 October 2009 Vol. 2, Issue 92, p. ra62[DOI: 10.1126/scisignal.2000356]

  日本語要約][英文原文
(06 October 2009)
 

酸素と糖の欠乏に対する協調的応答がイネの苗に洪水耐性をもたらす

Coordinated Responses to Oxygen and Sugar Deficiency Allow Rice Seedlings to Tolerate Flooding
Kuo-Wei Lee1,6, Peng-Wen Chen2, Chung-An Lu3, Shu Chen4, Tuan-Hua David Ho5, and Su-May Yu6*
Sci. Signal, 6 October 2009 Vol. 2, Issue 91, p. ra61[DOI: 10.1126/scisignal.2000333]

  日本語要約][英文原文
 

Winglessは勾配非依存性に増殖を促進する

Wingless Promotes Proliferative Growth in a Gradient-Independent Manner
Luis Alberto Baena-Lopez1*, Xavier Franch-Marro2,3*, and Jean-Paul Vincent1†
Sci. Signal, 6 October 2009 Vol. 2, Issue 91, p. ra60[DOI: 10.1126/scisignal.2000360]

  日本語要約][英文原文
(29 September 2009)
 

RASSF6のHippo経路依存的および非依存的な役割

Hippo Pathway-Dependent and-Independent Roles of RASSF6
Mitsunobu Ikeda1*, Akira Kawata1*, Misa Nishikawa1*, Yuko Tateishi1,2*, Masato Yamaguchi1, Kentaro Nakagawa1, Susumu Hirabayashi1, Yijun Bao1, ...
Sci. Signal, 29 September 2009 Vol. 2, Issue 90, p. ra59[DOI: 10.1126/scisignal.2000300]
日本語要約][英文原文

(22 September 2009)
 

ストレスのない状態ではMSK2はp53活性を阻害する

MSK2 Inhibits p53 Activity in the Absence of Stress
Susana Llanos1*, Ana Cuadrado2, and Manuel Serrano1*
Sci. Signal, 22 September 2009 http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/89/ra57

  日本語要約][英文原文
 

ヒト受容体型チロシンキナーゼの単一膜貫通ドメインが自己相互作用をコードする

The Single Transmembrane Domains of Human Receptor Tyrosine Kinases Encode Self-Interactions
Carmen Finger1,2*, Claudia Escher1*, and Dirk Schneider1†
Sci. Signal, 22 September 2009 Vol. 2, Issue 89, p. ra56[DOI: 10.1126/scisignal.2000547]

  日本語要約][英文原文
(15 September 2009)
 

新規p47phox関連オーガナイザーによる限局性NADPHオキシダーゼ1(Nox1)の調節

Novel p47phox -Related Organizers Regulate Localized NADPH Oxidase 1 (Nox1) Activity
Davide Gianni1,2, Begona Diaz3, Nicolas Taulet1,2, Bruce Fowler1,2, Sara A. Courtneidge3*, and Gary M. Bokoch1,2*
Sci. Signal, 15 September 2009 Vol. 2, Issue 88, p. ra54[DOI: 10.1126/scisignal.2000370]

  日本語要約][英文原文
 

Tks5依存性のNoxを介する活性酸素種産生は、浸潤突起形成に必要

Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation
Begona Diaz*, Gidon Shani*, Ian Pass, Diana Anderson, Manuela Quintavalle, and Sara A. Courtneidge†
Sci. Signal, 15 September 2009 Vol. 2, Issue 88, p. ra53[DOI: 10.1126/scisignal.2000368]

  日本語要約][英文原文
(08 September 2009)
 

チロシンキナーゼFerは細胞遊走を調節するPLD-PA経路の下流標的である

The Tyrosine Kinase Fer Is a Downstream Target of the PLD-PA Pathway that Regulates Cell Migration
Toshiki Itoh1*, Junya Hasegawa1, Kazuya Tsujita2, Yasunori Kanaho3, and Tadaomi Takenawa2*
Sci. Signal, 8 September 2009 Vol. 2, Issue 87, p. ra52[DOI: 10.1126/scisignal.2000393]

  日本語要約][英文原文
 

インテグリン会合複合体のプロテオミクス分析による、Rac1およびArf6の二重調節因子としてのRCC2の同定

Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6
Jonathan D. Humphries1,2*, Adam Byron1,2*, Mark D. Bass1,2, Sue E. Craig1,2, John W. Pinney2†, David Knight2, and Martin J. Humphries1,2‡
Sci. Signal, 8 September 2009 Vol. 2, Issue 87, p. ra51[DOI: 10.1126/scisignal.2000396]
日本語要約][英文原文

 

ドメインファミリーにおける機能的複雑性の急速な進化

Rapid Evolution of Functional Complexity in a Domain Family
Andreas Ernst1*, Stephen L. Sazinsky2, Shirley Hui3,4, Bridget Currell5, Moyez Dharsee3, Somasekar Seshagiri5, Gary D. Bader3,4, and Sachdev S. Sidhu1*†
Sci. Signal, 8 September 2009 Vol. 2, Issue 87, p. ra50[DOI: 10.1126/scisignal.2000416]
日本語要約][英文原文

(01 September 2009)
 

IL-1は前立腺の発生および反応性過形成においてIGF依存性の上皮増殖を誘導する

IL-1 Induces IGF-Dependent Epithelial Proliferation in Prostate Development and Reactive Hyperplasia
Travis J. Jerde* and Wade Bushman*
Sci. Signal, 1 September 2009 Vol. 2, Issue 86, p. ra49[DOI: 10.1126/scisignal.2000338]

  日本語要約][英文原文
(25 August 2009)
 

VDAC2-BAK加減抵抗器が胸腺リンパ球の生存を制御する

The VDAC2-BAK Rheostat Controls Thymocyte Survival
Decheng Ren1, Hyungjin Kim1, Ho-Chou Tu1, Todd D. Westergard1, Jill K. Fisher2, Jeff A. Rubens2, Stanley J. Korsmeyer2*, James J.-D. Hsieh1, ...
Sci. Signal, 25 August 2009 Vol. 2, Issue 85, p. ra48[DOI: 10.1126/scisignal.2000274]

  日本語要約][英文原文
(18 August 2009)
 

マイトフュージン2はミトコンドリア抗ウイルスシグナル伝達を抑制する

Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling
Kai YasukaKai Yasukawa1, Hiroyuki Oshiumi2, Makoto Takeda3, Naotada Ishihara4, Yusuke Yanagi3, Tsukasa Seya2, Shun-ichiro Kawabata1, and Takumi Koshiba1*
Sci. Signal, 18 August 2009 Vol. 2, Issue 84, p. ra47[DOI: 10.1126/scisignal.2000287]

  日本語要約][英文原文
 

T細胞受容体シグナル伝達の定量的リン酸化プロテオーム解析によって、系全体にわたるタンパク質間相互作用の調節が明らかになる

Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions
Viveka Mayya1, Deborah H. Lundgren1, Sun-Il Hwang1, Karim Rezaul1, Linfeng Wu1, Jimmy K. Eng2, Vladimir Rodionov3, and David K. Han1*
Sci. Signal, 18 August 2009 Vol. 2, Issue 84, p. ra46[DOI: 10.1126/scisignal.2000007]

  日本語要約][英文原文
 

腫瘍形成時のp19Arf欠損がもたらすp53非依存性の異なる結果

Differential p53-Independent Outcomes of p19Arf Loss in Oncogenesis
Zhenbang Chen1,2*, Arkaitz Carracedo1,2, Hui-Kuan Lin2†, Jason A. Koutcher3, Nille Behrendt2, Ainara Egia1,2, Andrea Alimonti1,2, Brett S. Carver4, ...
Sci. Signal, 18 August 2009 Vol. 2, Issue 84, p. ra44[DOI: 10.1126/scisignal.2000053]

  日本語要約][英文原文
(11 August 2009)
 

CD3εのコンホメーション変異体によって明らかになったT細胞受容体複合体間の協同性

Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3ε
Nuria Martinez-Martin1*, Ruth M. Risueno1*, Antonio Morreale2*, Irene Zaldivar1, Elena Fernandez-Arenas1, Fernando Herranz2, Angel R. Ortiz2†, and Balbino Alarcon1‡
Sci. Signal, 11 August 2009 Vol. 2, Issue 83, p. ra43[DOI: 10.1126/scisignal.2000402]

  日本語要約][英文原文
 

プロテインキナーゼDの神経と腸のアイソフォームはNa+(塩味)誘導性の学習を媒介する

Neuronal and Intestinal Protein Kinase D Isoforms Mediate Na+ (Salt Taste)-Induced Learning
Ya Fu1, Min Ren1*, Hui Feng1†, Lu Chen1, Zeynep F. Altun2, and Charles S. Rubin1‡
Sci. Signal, 11 August 2009 Vol. 2, Issue 83, p. ra42[DOI: 10.1126/scisignal.2000224]

  日本語要約][英文原文
(04 August 2009)
 

Akt1‐eNOS軸がin vivoでのキナーゼ‐基質関係の特異性を説明する

The Akt1-eNOS Axis Illustrates the Specificity of Kinase-Substrate Relationships in Vivo
Michael Schleicher1, Jun Yu1, Takahisa Murata2, Berhad Derakhshan1, Dimitriy Atochin3, Li Qian3, Satoshi Kashiwagi3, Annarita Di Lorenzo1, ...
Sci. Signal, 4 August 2009 Vol. 2, Issue 82, p. ra41[DOI: 10.1126/scisignal.2000343]

  日本語要約][英文原文
(28 July 2009)
 

比較分析から、複数の疾患に関係する保存されたタンパク質リン酸化ネットワークが明らかになる

Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases
Chris Soon Heng Tan1,2*, Bernd Bodenmiller3*, Adrian Pasculescu1, Marko Jovanovic4, Michael O. Hengartner4, Claus Jorgensen1, Gary D. Bader1,2, ...
Sci. Signal, 28 July 2009 Vol. 2, Issue 81, p. ra39[DOI: 10.1126/scisignal.2000316]

  日本語要約][英文原文
 

MAPKシグナル伝達におけるRas-c-Raf複合体の会合速度定数の重要性は細胞種に特異的である

Cell Type-Specific Importance of Ras-c-Raf Complex Association Rate Constants for MAPK Signaling
Christina Kiel1* and Luis Serrano1,2
Sci. Signal, 28 July 2009 Vol. 2, Issue 81, p. ra38[DOI: 10.1126/scisignal.2000397]

  日本語要約][英文原文
(21 July 2009)
 

IFN-γシグナル伝達を標的とする細胞透過性SOCS1の細胞内導入

Intracellular Delivery of a Cell-Penetrating SOCS1 that Targets IFN-γ Signaling
Antonio DiGiandomenico, Lukasz S. Wylezinski, and Jacek Hawiger*
Sci. Signal, 21 July 2009 Vol. 2, Issue 80, p. ra37[DOI: 10.1126/scisignal.1162191]

  日本語要約][英文原文
 

パーキンソン病におけるTORシグナル伝達阻害によるL-ドーパ誘発性ジスキネジアの予防

Inhibition of mTOR Signaling in Parkinson’s Disease Prevents L-DOPA-Induced Dyskinesia
Emanuela Santini1, Myriam Heiman2, Paul Greengard2, Emmanuel Valjent1,3,4,5, and Gilberto Fisone1,2*
Sci. Signal, 21 July 2009 Vol. 2, Issue 80, p. ra36[DOI: 10.1126/scisignal.2000308]

  日本語要約][英文原文
 

SIK1は、LKB1をp53依存性アノイキスに共役させてがんの転移を抑制する

SIK1 Couples LKB1 to p53-Dependent Anoikis and Suppresses Metastasis
Hailing Cheng1,2, Pixu Liu1,2*, Zhigang C. Wang1,3*, Lihua Zou1,3*, Stephanie Santiago1,2, Victoria Garbitt1,2, Ole V. Gjoerup4, J. Dirk Iglehart1,3,…
Sci. Signal, 21 July 2009 Vol. 2, Issue 80, p. ra35[DOI: 10.1126/scisignal.2000369]

  日本語要約][英文原文
(14 July 2009)
 

イノシトール1,4,5-トリスリン酸の非対称シグナルによる神経細胞成長円錐ナビゲーションの制御

Control of Neuronal Growth Cone Navigation by Asymmetric Inositol 1,4,5-Trisphosphate Signals
Hiroki Akiyama1, Toru Matsu-ura2, Katsuhiko Mikoshiba2, and Hiroyuki Kamiguchi1*
Sci. Signal, 14 July 2009 Vol. 2, Issue 79, p. ra34[DOI: 10.1126/scisignal.2000196]

  日本語要約][英文原文
(07 July 2009)
 

酸素による調節をうけるβ2-アドレナリン作動性受容体のEGLN3によるヒドロキシ化とpVHLによるユビキチン化

RESEARCH
Oxygen-Regulated β2-Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL
Liang Xie1, Kunhong Xiao1, Erin J. Whalen1, Michael T. Forrester2, Robert S. Freeman3, Guohua Fong4, Steven P. Gygi5, Robert J. Lefkowitz1,2,6, …
Sci. Signal, 7 July 2009 Vol. 2, Issue 78, p. ra33[DOI: 10.1126/scisignal.2000444]

  日本語要約][英文原文
(30 June 2009)
 

α5インテグリン-ZO-1複合体のPKCεによる調節は、遊走がん細胞におけるラメラ形成を制御する

PKCε Regulation of an α5 Integrin-ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells
Saara Tuomi1, Anja Mai1, Jonna Nevo1, Jukka O. Laine2, Vesa Vilkki3, Tiina J. Ohman4, Carl G. Gahmberg4, Peter J. Parker5,6, and Johanna Ivaska1,7*
Sci. Signal, 30 June 2009 Vol. 2, Issue 77, p. ra32[DOI: 10.1126/scisignal.2000135]

  日本語要約][英文原文
 

治療標的EfbB3:ErbB受容体‐PI3K軸のリガンド誘導活性化における主要ノード

Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor-PI3K Axis
Birgit Schoeberl*, Emily A. Pace*, Jonathan B. Fitzgerald*, Brian D. Harms, Lihui Xu, Lin Nie, Bryan Linggi, Ashish Kalra, Violette Paragas, Raghida Bukhalid, Viara Grantcharova, Neeraj Kohli, Kip A. West, Magdalena Leszczyniecka, Michael J. Feldhaus,...
Sci. Signal, 30 June 2009 Vol. 2, Issue 77, p. ra31[DOI: 10.1126/scisignal.2000352]

  日本語要約][英文原文
(23 June 2009)
 

PKC-θは、Cbl-bをユビキチン化および分解の標的とすることによって、T細胞応答の強度を調節する

PKC-θ Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation
Thomas Gruber1, Natascha Hermann-Kleiter1, Reinhard Hinterleitner1, Friedrich Fresser1, Rainer Schneider2, Gunther Gastl3, Josef M. Penninger4, and Gottfried Baier1*
Sci. Signal, 23 June 2009 Vol. 2, Issue 76, p. ra30[DOI: 10.1126/scisignal.2000046]

  日本語要約][英文原文
 

キネシンタンパク質Kif7は哺乳類のヘッジホッグシグナル伝達においてGli転写因子の重要な調節因子である

The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling
Helen Oi-Lam Cheung1,2*, Xiaoyun Zhang1, Ana Ribeiro3, Rong Mo1, Shigeru Makino1†, Vijitha Puviindran1, Kelvin K. L. Law1,2, James Briscoe3, and Chi-chung Hui1,2‡
Sci. Signal, 23 June 2009 Vol. 2, Issue 76, p. ra29[DOI: 10.1126/scisignal.2000405]

  日本語要約][英文原文
(16 June 2009)
 

cAMPによるマクロファージのLPS誘導性TNF-α産生の抑制はPKA-AKAP95-p105により媒介される

Suppression of LPS-Induced TNF-α Production in Macrophages by cAMP Is Mediated by PKA-AKAP95-p105
Estelle A. Wall1*†, Joelle R. Zavzavadjian1*‡, Mi Sook Chang1*§, Baljinder Randhawa1||, Xiaocui Zhu, Robert C. Hsueh2#, Jamie Liu1, Adrienne Driver1**,...
Sci. Signal, 16 June 2009 Vol. 2, Issue 75, p. ra28[DOI: 10.1126/scisignal.2000202]

  日本語要約][英文原文
(09 June 2009)
 

PI3Kγのアダプターサブユニットはマスト細胞における異なるPtdIns(3,4,5)P3プールによる脱顆粒と細胞運動との共役を決定する

PI3Kγ Adaptor Subunits Define Coupling to Degranulation and Cell Motility by Distinct PtdIns(3,4,5)P3 Pools in Mast Cells
Thomas Bohnacker1, Romina Marone1*, Emilie Collmann1*, Ronan Calvez1†, Emilio Hirsch2, and Matthias P. Wymann1‡
Sci. Signal, 9 June 2009 Vol. 2, Issue 74, p. ra27[DOI: 10.1126/scisignal.2000259]

  日本語要約][英文原文
(02 June 2009)
 

哺乳類の概日リズムの調節へのプロテインキナーゼCK2の関与

Involvement of the Protein Kinase CK2 in the Regulation of Mammalian Circadian Rhythms
Yoshiki Tsuchiya1*†, Makoto Akashi2*, Mitsuhiro Matsuda1, Kyoko Goto1, Yoshihiko Miyata1, Koichi Node3, and Eisuke Nishida1‡
Sci. Signal, 2 June 2009 Vol. 2, Issue 73, p. ra26[DOI: 10.1126/scisignal.2000305]

  日本語要約][英文原文
(26 May 2009)
 

Wnt-β-カテニンシグナル伝達の負の調節因子であることが判明したブルトン型チロシンキナーゼ

Bruton’s Tyrosine Kinase Revealed as a Negative Regulator of Wnt-β-Catenin Signaling
Richard G. James1,2*, Travis L. Biechele1,2*, William H. Conrad1,2, Nathan D. Camp1,2, Daniel M. Fass3†, Michael B. Major1,2, Karen Sommer4, XianHua Yi5, ...
Sci. Signal, 26 May 2009 Vol. 2, Issue 72, p. ra25[DOI: 10.1126/scisignal.2000230]

  日本語要約][英文原文
 

熱ショックに対する系全体のSUMO修飾への変化

System-Wide Changes to SUMO Modifications in Response to Heat Shock
Filip Golebiowski1*, Ivan Matic2*, Michael H. Tatham1*, Christian Cole3, Yili Yin1, Akihiro Nakamura4, Jurgen Cox2, Geoffrey J. Barton3, Matthias Mann2, ...
Sci. Signal, 26 May 2009 Vol. 2, Issue 72, p. ra24[DOI: 10.1126/scisignal.2000282]

  日本語要約][英文原文
(19 May 2009)
 

TRPM2はβ細胞においてリソソームのCa2+放出チャネルとして機能する

TRPM2 Functions as a Lysosomal Ca2+-Release Channel in β Cells
Ingo Lange1,2, Shinichiro Yamamoto3, Santiago Partida-Sanchez4,5, Yasuo Mori3, Andrea Fleig1,2, and Reinhold Penner1,2*
Sci. Signal, 19 May 2009 Vol. 2, Issue 71, p. ra23[DOI: 10.1126/scisignal.2000278]

  日本語要約][英文原文
 

複雑なネットワークの系からシグナル伝達の結果を解読する

Deciphering Signaling Outcomes from a System of Complex Networks
Robert C. Hsueh1*†, Madhusudan Natarajan1*‡, Iain Fraser2, Blake Pond1, Jamie Liu2, Susanne Mumby1, Heping Han1, Lily I. Jiang1, Melvin I. Simon2, ...
Sci. Signal, 19 May 2009 Vol. 2, Issue 71, p. ra22[DOI: 10.1126/scisignal.2000054]

  日本語要約][英文原文
(12 May 2009)
 

TRPM1はメラノサイト内のメラニン含量に関連するイオンチャネルを形成する

TRPM1 Forms Ion Channels Associated with Melanin Content in Melanocytes
Elena Oancea1*†, Joris Vriens1‡, Sebastian Brauchi, Janice Jun1, Igor Splawski2, and David E. Clapham1
Sci. Signal, 12 May 2009 Vol. 2, Issue 70, p. ra21[DOI: 10.1126/scisignal.2000146]

  日本語要約][英文原文
(05 May 2009)
 

活性化ドメインとメディエーターの境界における転写制御の複雑さ

Complexity in Transcription Control at the Activation Domain-Mediator Interface
Michael A. Balamotis1, Mario A. Pennella1, Jennitte L. Stevens2, Bohdan Wasylyk3, Andrew S. Belmont4, and Arnold J. Berk1*
Sci. Signal, 5 May 2009 Vol. 2, Issue 69, p. ra20[DOI: 10.1126/scisignal.1164302]

  日本語要約][英文原文
(28 April 2009)
 

神経伝達物質は組み合わせによる多状態のシナプス後肥厚部ネットワークを駆動する

Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks
Marcelo P. Coba1, Andrew J. Pocklington2, Mark O. Collins3, Maksym V. Kopanitsa1, Rachel T. Uren1, Sajani Swamy3, Mike D. R. Croning1, Jyoti S. Choudhary3, …
Sci. Signal, 28 April 2009 Vol. 2, Issue 68, p. ra19[DOI: 10.1126/scisignal.2000102]

  日本語要約][英文原文
 

LRP1へのリガンド結合はSrcファミリーキナーゼ依存性経路によってTrk受容体をトランスに活性化する

Ligand Binding to LRP1 Transactivates Trk Receptors by a Src Family Kinase-Dependent Pathway
Yang Shi1, Elisabetta Mantuano1,2, Gen Inoue2,3, W. Marie Campana2, and Steven L. Gonias1*
Sci. Signal, 28 April 2009 Vol. 2, Issue 68, p. ra18[DOI: 10.1126/scisignal.2000188]

  日本語要約][英文原文
 

Gαi1およびGαi3は、上皮増殖因子を介するAkt-mTORC1シグナル伝達経路の活性化に必要である

Gαi1 and Gαi3 Are Required for Epidermal Growth Factor-Mediated Activation of the Akt-mTORC1 Pathway
Cong Cao1,2, Xuesong Huang1, Yuyuan Han1, Yinsheng Wan3, Lutz Birnbaumer4, Geng-Sheng Feng5, John Marshall6, Meisheng Jiang7, and Wen-Ming Chu1,2*
Sci. Signal, 28 April 2009 Vol. 2, Issue 68, p. ra17[DOI: 10.1126/scisignal.2000118]

  日本語要約][英文原文
(14 April 2009)
 

ショウジョウバエの胚では機械的シグナルがミオシン IIの再分布と中胚葉陥入を誘発する

Mechanical Signals Trigger Myosin II Redistribution and Mesoderm Invagination in Drosophila Embryos
Philippe-Alexandre Pouille*, Padra Ahmadi*, Anne-Christine Brunet, and Emmanuel Farge †
Sci. Signal, 14 April 2009 Vol. 2, Issue 66, p. ra16[DOI: 10.1126/scisignal.2000098]

  日本語要約][英文原文
(07 April 2009)
 

T細胞の活性化における時空間パターン形成は極めて多様である

Spatiotemporal Patterning During T Cell Activation Is Highly Diverse
Kentner L. Singleton1*, Kole T. Roybal1*, Yi Sun1, Guo Fu2, Nicholas R. J. Gascoigne2, Nicolai S. C. van Oers1, and Christoph Wulfing1,3 †
Sci. Signal, 7 April 2009 Vol. 2, Issue 65, p. ra15[DOI: 10.1126/scisignal.2000199]

  日本語要約][英文原文
(31 March 2009)
 

Nogo受容体のリン酸化はNogoシグナル伝達を抑制し、神経突起の再生を可能にする

Phosphorylation of Nogo Receptors Suppresses Nogo Signaling, Allowing Neurite Regeneration
Yoshinori Takei*
Sci. Signal, 31 March 2009 Vol. 2, Issue 64, p. ra14[DOI: 10.1126/scisignal.2000062]

  日本語要約][英文原文
(24 March 2009)
 

結核菌(Mycobacterium tuberculosis)においては分子内スイッチがリン酸化非依存的なFHAドメインの相互作用を調節する

An Intramolecular Switch Regulates Phosphoindependent FHA Domain Interactions in Mycobacterium tuberculosis
Timothy J. Nott1, Geoff Kelly2, Lasse Stach1, Jiejin Li1, Sarah Westcott1, Dony Patel1, Debbie M. Hunt3, Steven Howell1, Roger S. Buxton3,...
Sci. Signal, 24 March 2009 Vol. 2, Issue 63, p. ra12[DOI: 10.1126/scisignal.2000212]

  日本語要約][英文原文
(17 March 2009)
 

肥満は、AktおよびmTORの慢性的活性化を通して、血管老化および虚血障害に対する感受性を亢進させる

Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR
Chao-Yung Wang1, Hyung-Hwan Kim1, Yukio Hiroi1, Naoki Sawada1, Salvatore Salomone2, Laura E. Benjamin3, Kenneth Walsh4, Michael A. Moskowitz2...
Sci. Signal, 17 March 2009 Vol. 2, Issue 62, p. ra11[DOI: 10.1126/scisignal.2000143]

  日本語要約][英文原文
(10 March 2009)
 

Rac1は、内皮由来の神経栄養活性に不可欠な介在因子である

Rac1 Is a Critical Mediator of Endothelium-Derived Neurotrophic Activity
Naoki Sawada1, Hyung-Hwan Kim1, Michael A. Moskowitz2, and James K. Liao1*
Sci. Signal, 10 March 2009 Vol. 2, Issue 61, p. ra10[DOI: 10.1126/scisignal.2000162]

  日本語要約][英文原文
(03 March 2009)
 

哺乳類受容体レパートリーによる匂いコーディング

Odor Coding by a Mammalian Receptor Repertoire
Harumi Saito 1* †, Qiuyi Chi 1, Hanyi Zhuang 1 ‡, Hiroaki Matsunami 1,2 §, and Joel D. Mainland 1 †§
Sci. Signal, 3 March 2009 Vol. 2, Issue 60, p. ra9[DOI: 10.1126/scisignal.2000016]

  日本語要約][英文原文
(24 February 2009)
 

インターロイキン17受容体のシグナル伝達は、調節ドメイン2で連続して起こるリン酸化によってC/EBPβを阻害する

IL-17 Receptor Signaling Inhibits C/EBPβ by Sequential Phosphorylation of the Regulatory 2 Domain
Fang Shen1*, Nan Li2, Padmaja Gade3, Dhananjaya V. Kalvakolanu3, Timothy Weibley1, Brad Doble4, James R. Woodgett5, Troy D. Wood2, and Sarah L. Gaffen1,6†
Sci. Signal, 24 February 2009 Vol. 2, Issue 59, p. ra8[DOI: 10.1126/scisignal.2000066]

  日本語要約][英文原文
 

Dok-7による筋受容体型キナーゼMuSKの活性化とシナプスの形態形成

Dok-7 Activates the Muscle Receptor Kinase MuSK and Shapes Synapse Formation
Akane Inoue1*, Kiyoko Setoguchi2*, Yosuke Matsubara2, Kumiko Okada2, Nozomi Sato3, Yoichiro Iwakura3, Osamu Higuchi1, and Yuji Yamanashi1†
Sci. Signal, 24 February 2009 Vol. 2, Issue 59, p. ra7[DOI: 10.1126/scisignal.2000113]

  日本語要約][英文原文
(17 February 2009)
 

FGF受容体自己リン酸化の正確な順序は速度論により決定され、発がん性変異により乱される

The Precise Sequence of FGF Receptor Autophosphorylation Is Kinetically Driven and Is Disrupted by Oncogenic Mutations
Erin D. Lew*, Cristina M. Furdui , Karen S. Anderson, and Joseph Schlessinger
Sci. Signal, 17 February 2009 Vol. 2, Issue 58, p. ra6[DOI: 10.1126/scisignal.2000021]

  日本語要約][英文原文
(10 February 2009)
 

BrxはNFAT5の活性化を介して浸透ストレスに対するリンパ球応答を媒介する

Brx Mediates the Response of Lymphocytes to Osmotic Stress Through the Activation of NFAT5
Tomoshige Kino1*, Hiroaki Takatori2, Irini Manoli3,4, Yonghong Wang5, Anatoly Tiulpakov1, Marc R. Blackman3,6, Yan A. Su7, George P. Chrousos1,4...
Sci. Signal, 10 February 2009 Vol. 2, Issue 57, p. ra5[DOI: 10.1126/scisignal.2000081]

  日本語要約][英文原文
(27 January 2009)
 

グリオーマにおいて、EGFRはPKCを介してAkt非依存的にmTORへシグナルを送る

EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma
Qi-Wen Fan1,2,3,4, Christine Cheng1,2,3,4, Zachary A. Knight5,6,7, Daphne Haas-Kogan3,4, David Stokoe3,4, C. David James3,4, Frank McCormick4, Kevan M. Shokat5,6,7,…
Sci. Signal, 27 January 2009 Vol. 2, Issue 55, p. ra4[DOI: 10.1126/scisignal.2000014]

  日本語要約][英文原文
 

内在性およびTSC2-GAPにより調節されるRhebのGTPase活性のリアルタイムNMRによる性質決定

Characterization of the Intrinsic and TSC2-GAP-Regulated GTPase Activity of Rheb by Real-Time NMR
Christopher B. Marshall1,2, Jason Ho1, Claudia Buerger1,2, Michael J. Plevin1,2, Guang-Yao Li1,2, Zhihong Li1,2, Mitsuhiko Ikura1,2*, and Vuk Stambolic1,2*
Sci. Signal, 27 January 2009 Vol. 2, Issue 55, p. ra3[DOI: 10.1126/scisignal.2000029]

  日本語要約][英文原文
 

有糸分裂終了組織と腫瘍形成におけるmTORの必要性の違い

Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis
Caterina Nardella1, Arkaitz Carracedo1*, Andrea Alimonti1*, Robin M. Hobbs1, John G. Clohessy1, Zhenbang Chen1, Ainara Egia1, Alessandro Fornari2,3,...
Sci. Signal, 27 January 2009 Vol. 2, Issue 55, p. ra2[DOI: 10.1126/scisignal.2000189]

  日本語要約][英文原文
 

Notch活性化に対する直接応答:シグナル伝達のクロストークと非干渉性の論理

Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic
Alena Krej?i*, Fred Bernard*, Ben E. Housden*, Stephanie Collins, and Sarah J. Bray
Sci. Signal, 27 January 2009 Vol. 2, Issue 55, p. ra1[DOI: 10.1126/scisignal.2000140]

  日本語要約][英文原文