Perspective バックナンバー 2006年 

(19 December 2006)
  シグナル伝達プラットフォームとしての中間径フィラメント
Intermediate Filaments as Signaling Platforms
Hanna-Mari Pallari1,2 and John E. Eriksson,3*
Sci. STKE, 19 December 2006 Vol. 2006, Issue 366, p. pe53 [DOI: 10.1126/stke.3662006pe53]
  日本語要約][英文原文
(12 December 2006)
  Oskarの野生型は何がそれほど特別なのか?
What Is So Special About Oskar Wild?
William O’Gorman and Alexandre Akoulitchev*
Sci. STKE, 12 December 2006 Vol. 2006, Issue 365, p. pe51 [DOI: 10.1126/stke.3652006pe51]
  日本語要約][英文原文
  癌におけるPI3キナーゼ:癌遺伝子のアーチファクトから有力な癌標的に
PI3 Kinases in Cancer: From Oncogene Artifact to Leading Cancer Target
Jean J. Zhao1,2 and Thomas M. Roberts1,3*
Sci. STKE, 12 December 2006 Vol. 2006, Issue 365, p. pe52 [DOI:10.1126/stke.3652006pe52]
  日本語要約][英文原文
(21 November 2006)
  PTEN調節、ホスホイノシチド3-キナーゼp85サブユニットの新機能
PTEN Regulation, a Novel Function for the p85 Subunit of Phosphoinositide 3-Kinase
Domingo F. Barber1, Maria Alvarado-Kristensson1, Ana Gonzalez-Garcia1, Rafael Pulido2, and Ana C. Carrera1*
Sci. STKE, 21 November 2006 Vol. 2006, Issue 362, p. pe49 [DOI: 10.1126/stke.3622006pe49]
  日本語要約][英文原文
  ユビキチンとNEDD8Brothers in Arms(戦友)
Ubiquitin and NEDD8: Brothers in Arms
Mirko H. H. Schmidt and Ivan Dikic*
Sci. STKE, 21 November 2006 Vol. 2006, Issue 362, p. pe50 [DOI: 10.1126/stke.3622006pe50]
  日本語要約][英文原文
(14 November 2006)
  特異化および分化の根底にあるメカニズムを解読する:ウニの遺伝子調節ネットワーク
Deciphering the Underlying Mechanism of Specification and Differentiation: The Sea Urchin Gene Regulatory Network
Smadar Ben-Tabou de-Leon* and Eric H. Davidson
Sci. STKE, 14 November 2006 Vol. 2006, Issue 361, p. pe47[DOI: 10.1126/stke.3612006pe47]
  日本語要約][英文原文
  胚発生におけるパターンの出現:ウニの初期発生におけるβ-カテニンの局在の調節
The Emergence of Pattern in Embryogenesis: Regulation of β-Catenin Localization During Early Sea Urchin Development
Charles A. Ettensohn
Sci. STKE, 14 November 2006 Vol. 2006, Issue 361, p. pe48[DOI: 10.1126/stke.3612006pe48]
  日本語要約][英文原文
(7 November 2006)
  INGにストレスを感じさせる−ホスホイノシチドは細胞ストレス応答に関与する
Stress-ING Out: Phosphoinositides Mediate the Cellular Stress Response
Matthew W. Bunce, Michael L. Gonzales, and Richard A. Anderson*
Sci. STKE, 7 November 2006 Vol. 2006, Issue 360, p. pe46 [DOI: 10.1126/stke.3602006pe46]
  日本語要約][英文原文
(24 October 2006)
  カスパーゼ阻害薬は代替的な細胞死経路を促進する
Caspase Inhibitors Promote Alternative Cell Death Pathways
Peter Vandenabeele*, Tom Vanden Berghe, and Nele Festjens
Sci. STKE, 24 October 2006Vol. 2006, Issue 358, p. pe44 [DOI: 10.1126/stke.3582006pe44]
  日本語要約][英文原文
  スーパー抗原:スーパー信号係?
Superantigens: Supersignalers?
Rose Zamoyska*
Sci. STKE, 24 October 2006 Vol. 2006, Issue 358, p. pe45 [DOI: 10.1126/stke.3582006pe45]
  日本語要約][英文原文
(17 October 2006)
  VRACが中枢神経系における新たなコミュニケーション機構への道を切り開く
VRACs CARVe a Path for Novel Mechanisms of Communication in the CNS
Sean J. Mulligan1 and Brian A. MacVicar2*
Sci. STKE, 17 October 2006 Vol. 2006, Issue 357, p. pe42[DOI: 10.1126/stke.3572006pe42]
  日本語要約][英文原文
  細菌の浸透圧受容
Osmosensing by Bacteria
Janet M. Wood*
Sci. STKE, 17 October 2006 Vol. 2006, Issue 357, p. pe43[DOI: 10.1126/stke.3572006pe43]
  日本語要約][英文原文
(10 October 2006)
  NMDA受容体活性のD‐セリン制御
D-Serine Regulation of NMDA Receptor Activity
Herman Wolosker*
Sci.STKE, Vol. 2006, Issue 356, p. pe41, 10 October 2006[DOI: 10.1126/stke.3562006pe41]
  日本語要約][英文原文
(3 October 2006)
  1つの主題の変奏曲:動物の発生過程におけるHoxおよびWntの組み合わせ調節
Variations on a Theme: Hox and Wnt Combinatorial Regulation During Animal Development
Sarah Bondos*
Sci.STKE, Vol. 2006, Issue 355, p. pe38, 3 October 2006[DOI: 10.1126/stke.3552006pe38]
  日本語要約][英文原文
  動脈と静脈の地図を作る
MAPping Out Arteries and Veins
Ryan E. Lamont and Sarah Childs*
Sci.STKE, Vol. 2006, Issue 355, p. pe39, 3 October 2006[DOI: 10.1126/stke.3552006pe39]
  日本語要約][英文原文
  高分子量の非コードRNAによる遺伝子制御
Gene Control by Large Noncoding RNAs
Ilya Shamovsky and Evgeny Nudler*
Sci.STKE, Vol. 2006, Issue 355, p. pe40, 3 October 2006[DOI: 10.1126/stke.3552006pe40]
  日本語要約][英文原文
(26 September 2006)
  p53による腫瘍抑制には、エンドスタチンおよびタムスタチンの抗血管新生活性が一部関与する
Tumor Suppression by p53 Is Mediated in Part by the Antiangiogenic Activity of Endostatin and Tumstatin
Judah Folkman*
Sci.STKE, Vol. 2006 Vol. 2006, Issue 354, p. pe35 [DOI: 10.1126/stke.3542006pe35]
  日本語要約][英文原文
  ブラシノステロイドシグナル伝達の理解における進展
Advances in Understanding Brassinosteroid Signaling
Rumyana Karlova and Sacco C. de Vries*
Sci.STKE, Vol. 2006 Vol. 2006, Issue 354, p. pe36 [DOI: 10.1126/stke.3542006pe36]
  日本語要約][英文原文
  Pufドメインタンパク質によるmRNAの調節
mRNA Regulation by Puf Domain Proteins
Robin P. Wharton1* and Aneel K. Aggarwal2*
Sci. STKE, 26 September 2006 Vol. 2006, Issue 354, p. pe37 [DOI: 10.1126/stke.3542006pe37]
  日本語要約][英文原文
(19 September 2006)
  トランスグルタミナーゼをGタンパク質共役受容体シグナル伝達とクロスリンクする
Cross-Linking Transglutaminases with G Protein-Coupled Receptor Signaling
Siiri E. Iismaa, Gillian E. Begg, and Robert M. Graham*
Sci.STKE, Vol. 2006, Issue 353, p. pe34, 19 September 2006[DOI: 10.1126/stke.3532006pe34]
  日本語要約][英文原文
(29 August 2006)
  多機能カリウムチャネル:一体化している電気的スイッチと酸化還元酵素
Multifunctional Potassium Channels: Electrical Switches and Redox Enzymes, All in One
Stefan H. Heinemann1* and Toshinori Hoshi2*
Sci.STKE, Vol. 2006, Issue 350, pp. pe33, 29 August 2006[DOI: 10.1126/stke.3502006pe33]
  日本語要約][英文原文
(22 August 2006)
  相手を選ばないPKAとRSKとの危険な関係
A RSK(y) Relationship with Promiscuous PKA
Miles D. Houslay*
Sci.STKE, Vol. 2006, Issue 349, pp. pe32, 22 August 2006[DOI: 10.1126/stke.3492006pe32]
  日本語要約][英文原文
(8 August 2006)
  シグナルを伝達する:G蛋白質が新しい個性を獲得
Transducing the Signals: A G Protein Takes a New Identity
Danny N. Dhanasekaran*
Sci.STKE, Vol. 2006, Issue 347, pp. pe31, 8 August 2006 [DOI: 10.1126/stke.3472006pe31]
  日本語要約][英文原文
(20 June 2006)
  細かい断片
"Bits" and Pieces
Michael B. Yaffe*
Sci.STKE, Vol. 2006, Issue 340, pp. pe28, 20 June 2006 [DOI: 10.1126/stke.3402006pe28]
  日本語要約][英文原文
(13 June 2006)
  RNA干渉を介する自然免疫防御
Innate Immune Defense Through RNA Interference
Jorg H. Fritz1, Stephen E. Girardin2, and Dana J. Philpott1*
Sci.STKE, Vol. 2006, Issue 339, pp. pe27, 13 June 2006 [DOI: 10.1126/stke.3392006pe27]
  日本語要約][英文原文
(06 June 2006)
  サイトカインの特異的分泌
Differential Secretion of Cytokines
Redwan Moqbel* and Jason J. Coughlin
Sci.STKE, Vol. 2006, Issue 338, pp. pe26, 6 June 2006 [DOI: 10.1126/stke.3382006pe26]
  日本語要約][英文原文
(30 May 2006)
  p19rasはMdm2によるp73の調節に新展開をもたらす
p19ras Brings a New Twist to the Regulation of p73 by Mdm2
Kelly Lynn Harms and Xinbin Chen*
Sci.STKE, Vol. 2006, Issue 337, pp. pe24, 30 May 2006 [DOI: 10.1126/stke.3372006pe24]
  日本語要約][英文原文
  HIFでブレーキをかける:ヒト悪性腫瘍の治療機会
HIFing the Brakes: Therapeutic Opportunities for Treatment of Human Malignancies
Joseph A. Garcia*
Sci.STKE, Vol. 2006, Issue 337, pp. pe25, 30 May 2006 [DOI: 10.1126/stke.3372006pe25]
  日本語要約][英文原文
(23 May 2006)
  セカンドメッセンジャーのパ・ド・ドゥ:カルシウムとcAMPの調和したダンス
Second Messenger Pas de Deux: The Coordinated Dance Between Calcium and cAMP
Laura N. Borodinsky* and Nicholas C. Spitzer
Sci.STKE, Vol. 2006, Issue 336, pp. pe22, 23 May 2006 [DOI: 10.1126/stke.3362006pe22]
  日本語要約][英文原文
  思考の糧:ミツバチの採集、記憶、およびアセチルコリン
Food for Thought: Honeybee Foraging, Memory, and Acetylcholine
Norman M. Weinberger*
Sci.STKE, Vol. 2006, Issue 336, pp. pe23, 23 May 2006 [DOI: 10.1126/stke.3362006pe23]
  日本語要約][英文原文
(16 May 2006)
  Cullin RINGユビキチンリガーゼのウイルス性モジュレーター:宿主の防御を逃れる(Culling the Host Defense)
Viral Modulators of Cullin RING Ubiquitin Ligases: Culling the Host Defense
Michele Barry1 and Klaus Fruh2*
Sci. STKE, Vol. 2006, Issue 333, pp. pe20, 2 May 2006 [DOI: 10.1126/stke.3332006pe20]
  日本語要約][英文原文
(02 May 2006)
  行き先はどこか?NMDA-D1受容体の捕捉
Where Do You Think You Are Going? The NMDA-D1 Receptor Trap
Carlos Cepeda and Michael S. Levine*
Sci. STKE, Vol. 2006, Issue 335, pp. pe21, 16 May 2006 [DOI: 10.1126/stke.3352006pe21]
  日本語要約][英文原文
(25 April 2006)
  ドーパミン作動性ニューロンは酸化ストレスにより不活性化する:パーキンソン病における死のカスケードの初期段階
Dopaminergic Neurons Reduced to Silence by Oxidative Stress: An Early Step in the Death Cascade in Parkinson’s Disease?
Patrick P. Michel1,2,3*, Merle Ruberg1,2, and Etienne Hirsch1,2
Sci. STKE, Vol. 2006, Issue 332, pp. pe19, 25 April 2006[DOI: 10.1126/stke.3322006pe19]
  日本語要約][英文原文
(11 April 2006)
  ユビキチン鎖結合様式はどのように関係しているか?
What’s Ub Chain Linkage Got to Do with It?
Ikjin Kim and Hai Rao*
Sci.STKE, Vol. 2006, Issue 330, pp. pe18, 11 April 2006 [DOI: 10.1126/stke.3302006pe18]
  日本語要約][英文原文
(04 April 2006)
  プロテオグリカンの独特の機能を解明する
Shedding Light on the Distinct Functions of Proteoglycans
Scott B. Selleck*
Sci.STKE, Vol. 2006, Issue 329, pp. pe17, 4 April 2006 [DOI: 10.1126/stke.3292006pe17]
  日本語要約][英文原文
(28 March 2006)
  BRAFおよびMEKの変異は遅れて登場する
BRAF and MEK Mutations Make a Late Entrance
Michael Y. Sherman* and Vladimir L. Gabai
Sci.STKE, Vol. 2006, Issue 328, pp. pe15, 28 March 2006 [DOI: 10.1126/stke.3282006pe15]
  日本語要約][英文原文
  哺乳類細胞内の複数の温度計:恒温生物の細胞はなぜ温度を測る必要があるのか?
Multiple Thermometers in Mammalian Cells: Why Do Cells from Homeothermic Organisms Need to Measure Temperature?
Michael Y. Sherman* and Vladimir L. Gabai
Sci.STKE, Vol. 2006, Issue 328, pp. pe16, 28 March 2006 [DOI: 10.1126/stke.3282006pe16]
  日本語要約][英文原文
(21 March 2006)
  グルタミン酸受容体輸送の複数の経路:表面拡散と膜輸送によって、受容体は協調的にシナプスへと運ばれる
Multiple Routes for Glutamate Receptor Trafficking: Surface Diffusion and Membrane Traffic Cooperate to Bring Receptors to Synapses
Laurent Cognet1, Laurent Groc2, Brahim Lounis1, and Daniel Choquet2*
Sci.STKE, Vol. 2006, Issue 327, pp. pe13, 21 March 2006 [DOI: 10.1126/stke.3272006pe13]
  日本語要約][英文原文
  ナノ粒子により作られる潜在性エピトープの検出
Detecting Cryptic Epitopes Created by Nanoparticles
Iseult Lynch1*, Kenneth A. Dawson1, and Sara Linse2
Sci.STKE, Vol. 2006, Issue 327, pp. pe14, 21 March 2006 [DOI: 10.1126/stke.3272006pe14]
  日本語要約][英文原文
(14 March 2006)
  TRPイオンチャネルの温度によるゲート開閉:思索のための食物?
Thermal Gating of TRP Ion Channels: Food for Thought?
Emily R. Liman*
Sci.STKE, Vol. 2006, Issue 326, pp. pe12, 14 March 2006[DOI: 10.1126/stke.3262006pe12]
  日本語要約][英文原文
(07 March 2006)
  ニューレグリン-1とミエリン形成
Neuregulin-1 and Myelination
Greg Lemke*
Sci.STKE, Vol. 2006, Issue 325, pp. pe11, 7 March 2006 [DOI: 10.1126/stke.3252006pe11]
  日本語要約][英文原文
(28 February 2006)
  会議報告:バロッサ2005−シグナル伝達ネットワーク
Meeting Report: Barossa 2005-Signaling Networks
Mark A. Guthridge*, Gregory J. Goodall, and Stuart M. Pitson
Sci.STKE, Vol. 2006, Issue 324, pp. pe9, 28 February 2006 [DOI: 10.1126/stke.3242006pe9]
  日本語要約][英文原文
  機能する脳におけるレチノイン酸シグナル伝達
Retinoic Acid Signaling in the Functioning Brain
Ursula C. Drager*
Sci.STKE, Vol. 2006,Issue 324, pp. pe10, 28 February 2006 [DOI: 10.1126/stke.3242006pe10]
  日本語要約][英文原文
(14 February 2006)
  鼻はどのくらい敏感か?
How Sensitive Is a Nose?
Richard G. Vogt*
Sci.STKE, Vol. 2006, Issue 322, pp. pe8, 14 February 2006[DOI: 10.1126/stke.3222006pe8]
  日本語要約][英文原文
(07 February 2006)
  ニューロン細胞膜におけるドコサヘキサエン酸の役割
Role of Docosahexaenoic Acid in Neuronal Plasma Membranes
John A. Glomset*
Sci.STKE, Vol. 2006, Issue 321, pp. pe6, 7 February 2006[DOI: 10.1126/stke.3212006pe6]
  日本語要約][英文原文
  膜におけるシグナル伝達複合体の構築
Building Signaling Complexes at the Membrane
Wonhwa Cho*
Sci. STKE, Vol.2006, Issue 321, pp. pe7, 7 February 2006[DOI: 10.1126/stke.3212006pe7]
  日本語要約][英文原文
(24 January 2006)
  2つのシグナルの物語:歯状回の神経発生におけるWntとHedgehog
A Tale of Two Signals: Wnt and Hedgehog in Dentate Neurogenesis
Christine D. Pozniak and Samuel J. Pleasure*
Sci. STKE, Vol. 2006, Issue 319, pp. pe5, 24 January 2006[DOI: 10.1126/stke.3192006pe5]
  日本語要約][英文原文
  下垂体のプロラクチン産生細胞(Lactotroph)に対するエンドセリンの作用:
1つの受容体、多くのGTP結合タンパク質

Endothelin Action on Pituitary Lactotrophs: One Receptor, Many GTP-Binding Proteins
Richard Bertram1,2*, Joel Tabak2*, Natalia Toporikova1*, and Marc E. Freeman2,3*
Sci. STKE, Vol. 2006, Issue 319, pp. pe4, 24 January 2006 [DOI: 10.1126/stke.3192006pe4]
  日本語要約][英文原文
(17 January 2006)
  ホスファチジルセリンとシグナル伝達:誰が誰を必要としているか?
Phosphatidylserine and Signal Transduction: Who Needs Whom?
M. Carmen Martinez, Corinne Kunzelmann, and Jean-Marie Freyssinet*
Sci. STKE, Vol. 2006, Issue 318, pp. pe3, 17 January 2006[DOI: 10.1126/stke.3182006pe3]
  日本語要約][英文原文
(10 January 2006)
  DNA損傷と腫瘍の監視:2つの経路への1つの引き金
DNA Damage and Tumor Surveillance: One Trigger for Two Pathways
Petter Hoglund
Sci. STKE, Vol. 2006, Issue 317, pp. pe2, 10 January 2006[DOI: 10.1126/stke.3172006pe2]
  日本語要約][英文原文
(03 January 2006)
  特集:炎症性腸疾患におけるインターフェロン-γ誘発性のタイトジャンクションタンパク質内部移行の重要性
The Significance of Interferon- γTriggered Internalization of Tight-Junction Proteins in Inflammatory Bowel Disease
Elizabeth M. Adler
Sci. STKE, Vol. 2006, Issue 316, pp. pe1, 3 January 2006[DOI: 10.1126/stke.3162006pe1]
  日本語要約][英文原文