Perspective バックナンバー 2007年 

SARM1の研究から、危険に対する免疫応答とニューロン応答のあいだの類似性が明らかになる
Studies of SARM1 Uncover Similarities Between Immune and Neuronal Responses to Danger
Marc Dalod*
Sci. STKE, 18 December 2007 Vol. 2007, Issue 417, p. pe73 [DOI: 10.1126/stke.4172007pe73]

抗炎症メディエータとしてのI型インターフェロン
Type I Interferons as Anti-Inflammatory Mediators
Etty N. Benveniste* and Hongwei Qin
Sci. STKE, 11 December 2007 Vol. 2007, Issue 416, p. pe70 [DOI: 10.1126/stke.4162007pe70]

リッツでリッチに
Putting on the RITz
Stefanie Kaech^1*, Gary Banker¹, and Phillip Stork²
Sci. STKE, 11 December 2007 Vol. 2007, Issue 416, p. pe71 [DOI: 10.1126/stke.4162007pe71]

ゲノム維持：p53とポリ（ADP-リボシル）化の結びつき
Genomic Maintenance: The p53 Poly(ADP-ribosyl)ation Connection
Rafael Alvarez-Gonzalez*
Sci. STKE, 4 December 2007 Vol. 2007, Issue 415, p. pe68 [DOI: 10.1126/stke.4152007pe68]

成長ホルモンレセプターの核局在化：サイトカイン作用の新たな大航海時代？
Nuclear Localization of Growth Hormone Receptor: Another Age of Discovery for Cytokine Action?
Steven M. Swanson^1,2* and John J. Kopchick^3,4
Sci. STKE, 4 December 2007 Vol. 2007, Issue 415, p. pe69 [DOI: 10.1126/stke.4152007pe69]

肝臓および膵臓における再生：へその緒を切るべき時？
Regeneration in Liver and Pancreas: Time to Cut the Umbilical Cord?
Yuval Dor1 and Ben Z. Stanger2*
Sci. STKE, 27 November 2007 Vol. 2007, Issue 414, p. pe66 [DOI: 10.1126/stke.4142007pe66]

SOS活性化機構の新たな洞察
New Insights into the Mechanisms of SOS Activation
Lawrence A. Quilliam*
Sci. STKE, 27 November 2007 Vol. 2007, Issue 414, p. pe67 [DOI: 10.1126/stke.4142007pe67]

アデニル酸シクラーゼ5：「若返りの泉」を探すのに新たな手掛かり？
Adenylyl Cyclase 5: A New Clue in the Search for the "Fountain of Youth"?
Julia A. Chester¹ and Val J. Watts^2*
Sci. STKE, 20 November 2007Vol. 2007, Issue 413, p. pe64 [DOI: 10.1126/stke.4132007pe64]

ショウジョウバエ概日時計の同調：光より熱
Entrainment of the Drosophila Circadian Clock: More Heat Than Light
Jin-Yuan Fan, Michael J. Muskus, and Jeffrey L. Price*
Sci. STKE, 20 November 2007 Vol. 2007, Issue 413, p. pe65 [DOI: 10.1126/stke.4132007pe65]

神経細胞遊走における細胞内カルシウムおよびRhoAの役割
The Role of Intracellular Calcium and RhoA in Neuronal Migration
Clare H. Faux and John G. Parnavelas*
Sci. STKE, 13 November 2007 Vol. 2007, Issue 412, p. pe62 [DOI: 10.1126/stke.4122007pe62]

タンブリング‐前進するための双方向様式
Tumbling, an Interactive Way to Move Forward
Hiroko Sano †, Sara Ricardo †, and Ruth Lehmann*
Sci. STKE, 13 November 2007 Vol. 2007, Issue 412, p. pe63 [DOI: 10.1126/stke.4122007pe63]

神経栄養因子とパーキンソン病：新プレーヤーの出現？
Neurotrophic Factors and Parkinson’s Disease: The Emergence of a New Player?
William Dauer*
Sci. STKE, 6 November 2007 Vol. 2007, Issue 411, p. pe60 [DOI: 10.1126/stke.4112007pe60]

学会報告：Zinc Signals 2007−生物学における遊離亜鉛イオンの役割の拡大
Meeting Report: Zinc Signals 2007-Expanding Roles of the Free Zinc Ion in Biology
Cathleen Frederickson^1,2, Christopher J. Frederickson^1,2,3*, Wolfgang Maret³, Harold Sandstead³, Leonard Giblin1, and Richard Thompson⁴
Sci. STKE, 6 November 2007 Vol. 2007, Issue 411, p. pe61 [DOI: 10.1126/stke.4112007pe61]

ニューロンかグリアか？　SHP2はすべてを知っているのか？
Neurons or Glia? Can SHP2 Know It All?
Volkan Coskun, Jing Zhao, and Yi E. Sun*
Sci. STKE, 30 October 2007 Vol. 2007, Issue 410, p. pe58 [DOI: 10.1126/stke.4102007pe58]

困ったときの錬金術：代謝シグナルを興奮性に変換する
Alchemy in the Soup:Transforming Metabolic Signals to Excitability
Colin G. Nichols*
Sci. STKE, 30 October 2007 Vol. 2007, Issue 410, p. pe59 [DOI: 10.1126/stke.4102007pe59]

受容体は外に目を向ける:シナプスへの興奮伝達シグナルの解明
Receptors Look Outward:Revealing Signals That Bring Excitation to Synapses
Kimberly Gerrow and Alaa El-Husseini*
Sci. STKE, 16 October 2007 Vol. 2007, Issue 408, p. pe56 [DOI: 10.1126/stke.4082007pe56]

PS（ホスファチジルセリン）への追記-アポトーシス細胞除去に関連するタンパク質
P.S. to PS (Phosphatidylserine)-Pertinent Proteins in Apoptotic Cell Clearance
Robert A. Schlegel1 and Patrick Williamson2*
Sci. STKE, 16 October 2007 Vol. 2007, Issue 408, p. pe57 [DOI: 10.1126/stke.4082007pe57]

攻撃的応答の調節における遺伝子−ホルモン−環境の相互作用：複雑な行動の洗練された分析
Gene-Hormone-Environment Interactions in the Regulation of Aggressive Responses: Elegant Analysis of Complex Behavior
Sci. STKE, 2 October 2007 Vol. 2007, Issue 406, p. pe55 [DOI: 10.1126/stke.4062007pe55]

インターフェロン50年：新しい分子、新しい可能性、新しい（そして古い）疑問
Interferon at 50: New Molecules, New Potential, New (and Old) Questions
Jerome A. Langer*
Sci. STKE, 25 September 2007 Vol. 2007, Issue 405, p. pe53[DOI: 10.1126/stke.4052007pe53]

生命の火：電気と再生
The Spark of Life: Electricity and Regeneration
Jonathan M. W. Slack*
Sci. STKE, 25 September 2007 Vol. 2007, Issue 405, p.pe54[DOI: 10.1126/stke.4052007pe54]

LKB1とAMPKの対話：細胞極で注目の話題
Dialogue Between LKB1 and AMPK: A Hot Topic at the Cellular Pole
Christelle Forcet and Marc Billaud*
Sci. STKE, 18 September 2007 Vol. 2007, Issue 404, p. pe51[DOI: 10.1126/stke.4042007pe51]

β-アクチン：NOS-3の調節因子
β-Actin: A Regulator of NOS-3
Yunchao Su1*, Dmitry Kondrikov1, and Edward R. Block1,2
Sci. STKE, 18 September 2007 Vol. 2007, Issue 404, p. pe52[DOI: 10.1126/stke.4042007pe52]

アリール炭化水素受容体：UVB反応を照らし出すエフェクター
The Aryl Hydrocarbon Receptor: An Illuminating Effector of the UVB Response
Patrizia Agostinis^1*, Marjan Garmyn², and An Van Laethem^1,2
Sci. STKE, 11 September 2007 Vol. 2007, Issue 403, p. pe49 [DOI: 10.1126/stke.4032007pe49]

ヘッジホッグシグナル伝達：Gas1でうまくいく
Hedgehog Signaling: Cooking with Gas1
Jong-Sun Kang1, Wei Zhang2, and Robert S. Krauss
Sci. STKE, 11 September 2007 Vol. 2007, Issue 403, p. pe50[DOI: 10.1126/stke.4032007pe50]

脳の発達と恒常性におけるToll様受容体
Toll-Like Receptors in Brain Development and Homeostasis
Peter H. Larsen, Thomas H. Holm, and Trevor Owens*
Sci. STKE, 4 September 2007 Vol. 2007, Issue 402, p. pe47 [DOI: 10.1126/stke.4022007pe47]

TLRによるT細胞の活性化：獲得免疫応答におけるTLRの役割
T Cell Activation by TLRs: A Role for TLRs in the Adaptive Immune Response
Heather MacLeod¹ and Lee M. Wetzler^2*
Sci. STKE, 4 September 2007 Vol. 2007, Issue 402, p. pe48 [DOI: 10.1126/stke.4022007pe48]

植物におけるTIRドメインの機能
The Functions of Plant TIR Domains
Tessa M. Burch-Smith and Savithramma P. Dinesh-Kumar*
Sci. STKE, 28 August 2007 Vol. 2007, Issue 401, p. pe46 [DOI: 10.1126/stke.4012007pe46]

活動的なシグナル：ゼブラフィッシュのケモカイン受容体と器官形成
Signals on the Move: Chemokine Receptors and Organogenesis in Zebrafish
Julie R. Perlin* and William S. Talbot
Sci. STKE, 21 August 2007 Vol. 2007, Issue 400, p. pe45 [DOI: 10.1126/stke.4002007pe45]

ニコチンと前頭前野のシナプス可塑性
Nicotine and Synaptic Plasticity in Prefrontal Cortex
Daniel S. McGehee*
Sci. STKE, 14 August 2007 Vol. 2007, Issue 399, p. pe44[DOI: 10.1126/stke.3992007pe44]

リンパ球のNFAT：すべてのイベントのための因子？
NFAT in Lymphocytes: A Factor for All Events?
Edgar Serfling*, Friederike Berberich-Siebelt, and Andris Avots
Sci. STKE, 7 August 2007 Vol. 2007, Issue 398, p. pe42[DOI: 10.1126/stke.3982007pe42]

ジアシルグリセロールキナーゼは免疫機能に歯止めをかける
Diacylglycerol Kinases Put the Brakes on Immune Function
Binks W. Wattenberg1* and Daniel M. Raben2
Sci. STKE, 7 August 2007 Vol. 2007, Issue 398, p. pe43 [DOI: 10.1126/stke.3982007pe43]

分子足場は、Wntと古典的な7回膜貫通型受容体シグナル伝達経路のあいだの双方向のクロストークを調節する
Molecular Scaffolds Regulate Bidirectional Crosstalk Between Wnt and Classical Seven-Transmembrane Domain Receptor Signaling Pathways
Thomas Force^1,2,3*, Kathleen Woulfe^1,3, Walter J. Koch¹, and Risto Kerkela¹
Sci. STKE, 31 July 2007 Vol. 2007, Issue 397, p. pe41[DOI: 10.1126/stke.3972007pe41]

エリスロポエチンには悪い側面（副作用）があるのか？Epoシグナル伝達とがん細胞
Does Erythropoietin Have a Dark Side? Epo Signaling and Cancer Cells
Arthur J. Sytkowski*
Sci. STKE, 17 July 2007 Vol. 2007, Issue 395, p. pe38 [DOI: 10.1126/stke.3952007pe38]

Foxp3は制御性T細胞の生涯を通じて必要とされる
Foxp3 Is Required Throughout the Life of a Regulatory T Cell
Jared E. Lopes^1,†, David M. Soper^1,†, and Steven F. Ziegler^1,2*
703Sci. STKE, 3 July 2007 Vol. 2007, Issue 393, p. pe36 [DOI: 10.1126/stke.3932007pe36]

神経細胞SNAREにおける電位依存性カリウムチャネルの驚くべき捕獲
The Surprising Catch of a Voltage-Gated Potassium Channel in a Neuronal SNARE
Durga P. Mohapatra, Helene Vacher, and James S. Trimmer*
Sci. STKE, 3 July 2007 Vol. 2007, Issue 393, p. pe37 [DOI: 10.1126/stke.3932007pe37]

Srcファミリーキナーゼを直接経由するGPCRのシグナル伝達
GPCRs Signaling Directly Through Src-Family Kinases
Deirdre McGarrigle and Xin-Yun Huang*
Sci. STKE, 26 June 2007 Vol. 2007, Issue 392, p. pe35 [DOI: 10.1126/stke.3922007pe35]

上皮の創傷治癒におけるRac1の二重の役割
Double Duty for Rac1 in Epidermal Wound Healing
C. Michael DiPersio*
Sci. STKE, 19 June 2007 Vol. 2007, Issue 391, p. pe33[DOI:10.1126/stke.3912007pe33]

BRCA1によるステロイド受容体のユビキチン化の制御
BRCA1 Control of Steroid Receptor Ubiquitination
George F. Heine and Jeffrey D. Parvin*
Sci. STKE, 19 June 2007 Vol. 2007, Issue 391, p. pe34 [DOI: 10.1126/stke.3912007pe34]

IL-33：オオカミの皮をかぶった羊？
IL-33: A Sheep in Wolf's Clothing?
Massimo Gadina^1* and Caroline A. Jefferies²
Sci. STKE, 12 June 2007 Vol. 2007, Issue 390, p. pe31[DOI: 10.1126/stke.3902007pe31]

同期する：カルシウムの概日振動の一部始終
In SYNC: The Ins and Outs of Circadian Oscillations in Calcium
Takato Imaizumi^1*, Julian I. Schroeder², and Steve A. Kay^1*
Sci. STKE, 12 June 2007 Vol. 2007, Issue 390, p. pe32[DOI: 10.1126/stke.3902007pe32]

再生医療の生物学
The Biology of Regenerative Medicine
Ken Muneoka*
Sci. STKE, 5 June 2007 Vol. 2007, Issue 389, p. pe30 [DOI: 10.1126/stke.3892007pe30]

X線結晶構造解析およびNMRがEFハンドタンパク質による細胞内カルシウムシグナル伝達に対して及ぼす影響：構造から生物学および医学への扉を開く
The Impact of X-ray Crystallography and NMR on Intracellular Calcium Signal Transduction by EF-Hand Proteins: Crossing the Threshold from Structure to Biology and Medicine
Walter J. Chazin*
Sci. STKE, 29 May 2007 Vol. 2007, Issue 388, p. pe27[DOI: 10.1126/stke.3882007pe27]

単一分子の動きを解析する：細胞表面の個々の受容体のダイナミクスを解明するための新しいアルゴリズム
Parsing the Motion of Single Molecules: A Novel Algorithm for Deconvoluting the Dynamics of Individual Receptors at the Cell Surface
Indraneel Ghosh* and Mary J. Wirth*
Sci. STKE, 29 May 2007 Vol. 2007, Issue 388, p. pe28[DOI: 10.1126/stke.3882007pe28]

単一細胞を分析するためのマイクロ流体デバイス：タンパク質を数え落とさない
Microfluidic Devices for the Analysis of Single Cells: Leaving No Protein Uncounted
Marian Navratil, Christofer E. Whiting, and Edgar A. Arriaga*
Sci. STKE, 29 May 2007 Vol. 2007, Issue 388, p. pe29[DOI: 10.1126/stke.3882007pe29]

自然免疫応答におけるマイクロマネージメント
Micromanagement During the Innate Immune Response
James E. Dahlberg* and Elsebet Lund
Sci. STKE, 22 May 2007 Vol. 2007, Issue 387, p. pe25[DOI: 10.1126/stke.3872007pe25]

書評：植物の遺伝子発現
Book Review: Plant Gene Expression
Alan Rose*
Sci. STKE, 22 May 2007 Vol. 2007, Issue 387, p. pe26[DOI: 10.1126/stke.3872007pe26]

シナプス外NMDA受容体が遺伝子の順位を決め直す
Extrasynaptic NMDA Receptors Reshape Gene Ranks
Igor Medina
Sci. STKE, 15 May 2007 Vol. 2007, Issue 386, p. pe23[DOI: 10.1126/stke.3862007pe23]

Ca²⁺シグナル伝達による核膜透過性の調節：厳蜜に調節された孔か水門（floodgate）か？
The Regulation of Nuclear Membrane Permeability by Ca²⁺ Signaling: A Tightly Regulated Pore or a Floodgate?
Katalin Torok
Sci. STKE, 15 May 2007 Vol. 2007, Issue 386, p. pe24 [DOI: 10.1126/stke.3862007pe24]

キノーム（kinome）のCdc37による調節：とどめておく時、折りたたむ時（When to Hold‘Em and When to Fold‘Em）
Cdc37 Regulation of the Kinome: When to Hold‘Em and When to Fold‘Em
Larry M. Karnitz1* and Sara J. Felts2
Sci. STKE, 8 May 2007 Vol. 2007, Issue 385, p.pe22 [DOI: 10.1126/stke.3852007pe22]

炎症の消散におけるプロとパートタイムのケモカインデコイ
Professional and Part-Time Chemokine Decoys in the Resolution of Inflammation
Chris Hansell and Robert Nibbs*
Sci. STKE, 1 May 2007 Vol. 2007, Issue 384, p. pe18 [DOI: 10.1126/stke.3842007pe18]

アクチベーターに反撃する：IκBキナーゼが抗原受容体応答をどのようにして終結させるのか
Striking Back at the Activator: How IκB Kinase Terminates Antigen Receptor Responses
Michael Hinz and Claus Scheidereit*
Sci. STKE, 1 May 2007 Vol. 2007, Issue 384, p. pe19 [DOI: 10.1126/stke.3842007pe19]

RIG-IとLGP2によるインターフェロン産生の調節：自己制御の教訓
Regulation of Interferon Production by RIG-I and LGP2: A Lesson in Self-Control
Damien Vitour and Eliane F. Meurs*
Sci. STKE, 1 May 2007 Vol. 2007, Issue 384, p. pe20 [DOI: 10.1126/stke.3842007pe20]

CARD-Bcl10-Malt1シグナロソーム：NF-κBとの失われたリンク
CARD-Bcl10-Malt1 Signalosomes: Missing Link to NF-κB
Elmar Wegener and Daniel Krappmann*
Sci. STKE, 1 May 2007 Vol. 2007, Issue 384, p.pe21[DOI: 10.1126/stke.3842007pe21]

取り残されるもの―生殖細胞の遊走における質的管理
What Is Left Behind-Quality Control in Germ Cell Migration
Bijan Boldajipour and Erez Raz*
Sci. STKE, 24 April 2007 Vol. 2007, Issue 383, p. pe16[DOI: 10.1126/stke.3832007pe16]

自家不和合性ポピーにおける花粉−雌蕊シグナル伝達：雌蕊におけるより効率的な資源配分を可能にするか？
Pollen-Pistil Signaling in Self-Incompatible Poppy: Does It Allow More Efficient Resource Allocation in the Pistil?
Bruce McClure*
Sci. STKE, 24 April 2007 Vol. 2007, Issue 383, p. pe17 [DOI: 10.1126/stke.3832007pe17]

PKAに依存しないERKへのcAMPシグナル伝達によるPC12細胞の分化の調節：すべてのつながりは１つにまとまるか？
Regulation of PC12 Cell Differentiation by cAMP Signaling to ERK Independent of PKA: Do All the Connections Add Up?
Matthew J. Gerdin* and Lee E. Eiden
Sci. STKE, 17 April 2007 Vol. 2007, Issue 382, p. pe15[DOI: 10.1126/stke.3822007pe15]

会議報告：腫瘍生物学―どのようにしてシグナル伝達過程を治療に応用するか
Meeting Report: Tumor Biology--How Signaling Processes Translate to Therapy
Karlheinz Friedrich1, Ottmar Janssen2, and Ralf Hass3*
Sci. STKE, 10 April 2007 Vol. 2007, Issue 381, p. pe13[DOI: 10.1126/stke.3812007pe13]

抗がん戦略として代謝を標的にする：新しい時代の幕開け？
Metabolic Targeting as an Anticancer Strategy: Dawn of a New Era?
James G. Pan1* and Tak W. Mak2*
Sci. STKE, 10 April 2007 Vol. 2007, Issue 381, p. pe14 [DOI: 10.1126/stke.3812007pe14]

FatハエがHippoシグナル伝達経路を発展させた：大きさの制御の問題
Fat Flies Expanded the Hippo Pathway: A Matter of Size Control
Feng Yin and Duojia Pan*
Sci. STKE, 3 April 2007 Vol. 2007, Issue 380, p. pe12[DOI: 10.1126/stke.3802007pe12]

NADPHオキシダーゼの従来とは異なる役割：シグナル伝達、イオンの恒常性、細胞死
Unconventional Roles of the NADPH Oxidase: Signaling, Ion Homeostasis, and Cell Death
Benjamin E. Steinberg and Sergio Grinstein
Sci. STKE, 27 March 2007 Vol. 2007, Issue 379, p. pe11[DOI: 10.1126/stke.3792007pe11]

接着斑の変動：すべりクラッチか、機械的測定器か、あるいはシグナル貯蔵所か
Flux at Focal Adhesions: Slippage Clutch, Mechanical Gauge, or Signal Depot
Yu-li Wang*
Sci. STKE, 13 March 2007 Vol. 2007, Issue 377, p. pe10 [DOI: 10.1126/stke.3772007pe10]

理解可能な複雑さ
Understandable Complexity
Jorg Stelling*
Sci. STKE, 6 March 2007 Vol. 2007, Issue 376, p. pe9 [DOI: 10.1126/stke.3762007pe9]

会議報告：カイノームを標的にする−バーゼルにおけるチロシンキナーゼ阻害薬研究の20年
Meeting Report: Targeting the Kinome-20 Years of Tyrosine Kinase Inhibitor Research in Basel
Lana Bozulic1, Pier Jr Morin1, Tony Hunter2, and Brian A. Hemmings^1*
Sci. STKE, 20 February 2007 Vol. 2007, Issue 374, p. pe8 [DOI: 10.1126/stke.3742007pe8]

甘味センサー、驚くべきパートナー
Sweet Sensor, Surprising Partners
Jin-Gui Chen*
Sci. STKE, 13 February 2007 Vol. 2007, Issue 373, p. pe7[DOI: 10.1126/stke.3732007pe7]

神経細胞の極性とキネシンスーパーファミリータンパク質
Neuronal Polarity and the Kinesin Superfamily Proteins
Takao Nakata and Nobutaka Hirokawa*
Sci. STKE, 6 February 2007 Vol. 2007, Issue 372, p. pe6[DOI: 10.1126/stke.3722007pe6]

EGFRシグナル伝達は、E2F1誘導性アポトーシスをin vivoで阻害する：癌治療に対する意義
EGFR Signaling Inhibits E2F1-Induced Apoptosis in Vivo: Implications for Cancer Therapy
Doron Ginsberg*
Sci. STKE, 30 January 2007 Vol. 2007, Issue 371, p. pe4 [DOI: 10.1126/stke.3712007pe4]